Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2

Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2. Halting these steps can cure COVID-19. Here we have identified and characterized a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Remarkably, HB27 can also prevent SARS-CoV-2 membrane fusion. Consequently, a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models. Rhesus macaques showed no obvious adverse events when administrated with 10 times the effective dose of HB27. Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor. Binding of the antibody also restrains any further conformational changes of the receptor binding domain, possibly interfering with progression from the prefusion to the postfusion stage. These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19.     

Overview of Telehealth and Its Application to Cardiopulmonary Physical Therapy

Advances in telecommunication technology provide unique opportunities for the provision of medical services to underserved and geographically displaced patients. Health care professionals currently use voice and video systems to communicate with patients and colleagues in a variety of clinical venues. Unfortunately, such systems have limited presence in physical therapy settings. A variety of factors, including lack of familiarity with existing devices and perceived system purchase and operation costs, appear to be limiting its use. Even the terminology is confusing with such terms as telehealth, telemedicine, and telerehabilitation often used interchangeably. The purpose of this paper is to present an overview of this technology and to provide a clinical perspective regarding the use of telehealth in cardiopulmonary physical therapy practice.Key Words: technology and health care, physical therapy

“The future has a habit of suddenly and dramatically becoming the present.”Roger A. Babson

     

The effects of a rational-emotive affective education program for high-risk middle school students

This study investigated the effects of participation in a developmentally appropriate affective education program. The independent variable was the rational-emotive curriculum Thinking, Feeling, Behaving: An Emotional Education Curriculum for Adolescents (Vernon, 1989), and the dependent variables were self-concept measured with the Tennessee Self-Concept Scale and end-of-year report card grades. Twenty-three middle school students who were identified as high risk for dropping out prior to completion of high school and also as learning disabled or emotionally disturbed were randomly assigned to experimental (n = 12) and control (n = 11) conditions. Participants in the affective education group met for approximately 45 minutes a week for 15 weeks. Self-concept and grades did not differ between the two groups.     

Construct validity of the Kaufman assessment battery for children with learning disabled and mentally retarded

This study investigated the construct validity of the Kaufman Assessment Battery for Children (K-ABC) via correlational procedures with the WISC-R. Thirty-two special population children selected from kindergarten through grade five participated in the study; 19 children were diagnosed as learning disabled, 13 as educable mentally retarded. A high relationship between the WISC-R FSIQ and the K-ABC Mental Processing composite revealed evidence of construct validity in the measurement of intelligence. The K-ABC diagnosed the learning disabled but failed to diagnose the mentally retarded children. The K-ABC Sequential Processing Scale appeared to offer a unique construct (analytic, temporal sequencing) not measured by the WISC-R. Implications for the usefulness of the K-ABC are discussed.     

Displacement in Young Adult Literature: A Thematic Analysis

Children's Literature in Education - Providing spaces for adolescents to make sense of the world around them is often the work of educators, specifically those in Language Arts classrooms. In...     

Impact of touring,performance schedule,and definitions on 1-year injury rates in a modern dance company

There is ongoing debate about how to define injury in dance: the most encompassing one or a time-loss definition. We examined the relationship between touring, performance schedule and injury definition on injury rates in a professional modern dance company over one-year. In-house healthcare management tracked 35 dancers for work-related musculoskeletal injuries (WMSI), time-loss injuries (TLinj), complaints, and exposure. The year was divided into 6 segments to allow comparison of effects of performance, rehearsal, and touring. Injuries/segment were converted into injuries/1000-h dance exposure. We conducted negative binomial regression analysis to determine differences between segments, P ≤ 0.05. Twenty WMSI, 0.44 injuries/1000-h, were sustained over one-year. WMSI were 6 times more likely to occur in Segment-6, compared with other segments (incident rate ratio = 6.055, P = 0.031). The highest rate of TLinj and traumatic injuries also occurred in Segment-6, reflecting concentrated rehearsal, New York season and performances abroad. More overuse injuries occurred in Segment-2, an international tour, attributed to raked stages. Lack of methods to quantify performance other than injury may mask effects of touring on dancer’s well-being. Tracking complaints permits understanding of stressors to specific body regions and healthcare utilisation; however, TLinj remain the most important injuries to track because they impact other dancers and organisational costs.     

When Children Treat Condemnation as a Signal: The Costs and Benefits of Condemnation

Condemnation is ubiquitous in the social world and adults treat condemnation as a costly signal. We explore when children begin to treat condemnation as a signal by presenting 4- to 9-year-old children (N = 435) with stories involving a condemner of stealing and a noncondemner. Children were asked to predict who would be more likely to steal as well as who should be punished more harshly for stealing. In five studies, we found that 7- to 9-year-old children treat condemnation as a signal—thinking that a condemner is less likely to steal and should be punished more harshly if caught hypocritically stealing later. We discuss the implications of these results for children’s emerging understanding of signaling and moral condemnation.     

“Everyone rolls up their sleeves and mucks in”: Exploring volunteers’ motivation and experiences of the motivational climate of a sporting event

Research examining volunteer motivation and satisfaction has been criticised for the limited explanation of the cognitive and social processes that may underpin the proposed relationships among motivation, satisfaction, performance and retention (Costa, C.A., Chalip, L., Green, B.C., & Simes, C. (2006). Reconsidering the role of training in event volunteers’ satisfaction. Sport Management Review, 9(2), 165–182.; Cuskelly, G., Hoye, R., & Auld, C. (2006). Working with volunteers in sport. Theory and practice. London: Routledge.). Self-determination theory (SDT) (Deci, E.L., & Ryan, R.M. (1985). Intrinsic motivation and self-determination in human behavior. New York: Plenum.; Ryan, R.M., & Deci, E.L. (2000a) has proven useful in both for- and not-for-profit domains (e.g., Baard, P.P. (1994). A motivational basis for consulting with not-for-profit organizations: A study of church growth and participation. Consulting Psychology Journal, 46(3), 19–31.; Deci, E.L., Connell, J.P., & Ryan, R.M. (1989). Self-determination in a work organisation. Journal of Applied Psychology, 74(4), 580–590.; Hollembeak, J., & Amorose, A. J. (2005). Percevied coaching behaviors and college athletes’ intrinsic motivation: A test of self-determination theory. Journal of Applied Sport Psychology, 17(1), 20–36.) and appears particularly suited to understanding volunteer motivation. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. American Psychologist, 55(1), 68–78.). Therefore the purpose of this study was to examine sport event volunteers’ motivation and experiences of the motivational climate at a large sport event using self-determination theory. The participants were volunteers at the NZ Master's Games held biannually in Dunedin, NZ. They participated in focus group interviews in which their experiences as volunteers at the event were discussed. In general, the findings support tenets of self-determination theory. Participants reported intrinsic motivation toward volunteering but also forms of extrinsic motivation toward some volunteer tasks. With regard to the motivational climate, volunteers experienced support for their autonomy, and felt that their competence and sense of relatedness were fostered. These findings suggest that SDT is a viable framework for examining volunteer motivation.     

Disentangling genetic and environmental influences on early language development: The interplay of genetic propensity for negative emotionality and surgency,and parenting behavior effects on early language skills in an adoption study

Parenting and children's temperament are important influences on language development. However, temperament may reflect prior parenting, and parenting effects may reflect genes common to parents and children. In 561 U.S. adoptees (57% male) and their birth and rearing parents (70% and 92% White, 13% and 4% African American, and 7% and 2% Latinx, respectively), this study demonstrated how genetic propensity for temperament affects language development, and how this relates to parenting. Genetic propensity for negative emotionality inversely predicted language at 27 months (β = −.15) and evoked greater maternal warmth (β = .12), whereas propensity for surgency positively predicted language at 4.5 years (β = .20), especially when warmth was low. Parental warmth (β = .15) and sensitivity (β = .19) further contributed to language development, controlling for common gene effects.