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排序方式: 共有104条查询结果,搜索用时 15 毫秒
51.
Amit Kumar Mani Tiwari Abbas Ali Mahdi Fatima Zahra Sudarshna Sharma Mahendra Pal Singh Negi 《Indian journal of clinical biochemistry : IJCB》2012,27(3):246-252
To correlate blood lead levels (BLLs) and oxidative stress parameters in pregnant anemic women. A total of 175 pregnant women were found suitable and included for this study. Following WHO criteria, 50 each were identified as non-anemic, mild anemic and moderate anemic and 25 were severe anemic. The age of all study subjects ranged from 24–41 years. At admission, BLLs and oxidative stress parameters were estimated as per standard protocols and subjected with ANOVA, Pearson correlation analysis and cluster analysis. Results showed significantly (p < 0.01) high BLLs, zinc protoporphyrin (ZPP), oxidized glutathione (GSSG), lipid peroxide (LPO) levels while low delta aminolevulinic acid dehydratase (δ-ALAD), iron (Fe), selenium (Se), zinc (Zn), haemoglobin (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), red blood cell (RBC) count, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant capacity (TAC) in all groups of anemic pregnant women as compared with non anemic pregnant women. In all groups of pregnant women, BLLs showed significant (p < 0.01) and direct association with ZPP, GSSG and LPO while inverse relation with δ-ALAD, Fe, Se, Zn, Hb, Hct, MCV, MCH, MCHC, RBC, GSH, SOD, CAT and TAC. Study concluded that low BLLs perturb oxidant-antioxidant balance and negatively affected hematological parameters which may eventually Pb to Fe deficiency anemia during pregnancy. 相似文献
52.
Vijay S. Bhat Amit Kumar Mandal Bobby Mathew 《Indian journal of clinical biochemistry : IJCB》2012,27(4):414-416
Hemoglobin J-Rajappen (alpha)90 Lys → Thr is an alpha chain variant found in heterozygous state and presents normal hematological blood picture. Due to the ambiguity in results obtained while analyzing by HPLC and alkaline gel electrophoresis, we report this rare case of HbJ-Rajappen using non denaturing gel electrophoresis and matrix assisted laser desorption ionization mass spectrometry. Though HbJ-Rajappen has earlier been reported using different techniques, this is the first report being validated using mass spectrometry technique. 相似文献
53.
54.
Amit Jain D. Puri M. M. A. Faridi 《Indian journal of clinical biochemistry : IJCB》1997,12(2):119-124
Double volume (170 ml/kg body weight) exchange transfusion was done in 52 term infants in the first week of life for neonatal
hyperbilirubinemia. The M:F ratio was 1.08:1 and 37 (71.1%) babies were of low birth weight. Causes of jaundice were hemolytic
in 46.2% and non-hemolytic in 41.3% cases; in 13.5% babies no cause of jaundice could be found. After exchange transfusion
a fall of 14.6% and 47.4% was observed in the hemoglobin and serum bilirubin levels respectively. There was significant (p=0.0414)
rise in the mean mid exchange and post-exchange serum sodium levels as compared to pre-exchange values and it was found to
be due to higher donor's serum sodium levels (p=0.007). There was no effect on the serum potassium levels during or after
ET.
In general serum calcium levels significantly increased at mid-exchange period (p=0.0029) but post-exchange levels were same
as pre-exchange. Donor's serum calcium level had no effect on the infant's serum calcium level (p=0.993). There was no change
in the serum phosphate and blood urea levels during and after exchange-transfusion. The plasma glucose was significantly raised
during and after ET and plasma glucose of the donors had significant effect on the infant's plasma glucose levels (p=0.043).
Similarly plasma osmolality also showed significant increase during and after ET which was due to the effect of donor's plasma
osmolality (p=0.007). 相似文献
55.
M Maneesh H Jayalekshmi Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(2):62-67
The study was undertaken to evaluate the possible involvement of oxidative stress in the pathogenesis of ethanol induced testicular
atrophy in rats. Adult male rats were orally administered ethanol at a dose of 1.6 g/kg body weight/day for four weeks. Twenty-four
hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were removed and weighed. Apoptosis
was studied by using the Feulgen reaction on 5 μ thin paraffin sections of testis. Testicular homogenate was prepared and
centrifuged. The supernatant was used for the estimation of extent of lipid peroxidation and antioxidant defense status. There
was significant reduction in body weight: and in testicular weight and diameter in ethanol treated rats. Extent of germ cell
apoptosis was significantly high in ethanol treated rats. Ethanol treated rats showed significantly high tissue TBARS level
and glutathione S-transferase activity; and low tissue ascorbic acid, reduced glutathione, superoxide dismutase, catalase,
glutathione peroxidase and glutathione reductase activities. Chronic ethanol administration resulted in high oxidative stress
in the testes either due to increased extent of lipid peroxidation or due to decreased antioxidant defenses, and thereby induces
germ cell apoptosis leading to testicular atrophy. 相似文献
56.
Ramesh Chandra Sujata K. Dass Priyanka Tomar Manisha Tiwari 《Indian journal of clinical biochemistry : IJCB》2001,16(2):145-152
As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin
envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger
of the stress response, it is synergistically toxic with all other stressors, including many other carcinogens. Elimination
of Pb and its replacement with added benzene in gasoline appears to have increased the toxicity of atmospheric Cd. With scientific
understanding of the molecular basis of Cd's role in carcinogenesis and anti-carcinogenesis, primary cancer prevention can
be practiced by reducing Cd and chemical air pollution and educating the public on smoke cessation, healthy eating habits
and stress reduction. Using the existing information on Cd and its effects, determinations could be made on established cancers
so that individualized treatment protocols can be developed to improve patient care. 相似文献
57.
Ramesh Chandra Manisha Tiwari Ritu Aneja Sujata K. Dass Archana Sharma 《Indian journal of clinical biochemistry : IJCB》2000,15(2):148-154
We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin
(CrPP) on phospholipase A2 (PLA2) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that
on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition
of PLA2 activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent
pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased
phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only
to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep
elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA2 activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to
membrane lysis. 相似文献
58.
Bilagher Moritz Kaushik Amit 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2020,66(1):93-113
International Review of Education - Accelerated learning programmes (ALPs) provide a fast-track second-chance opportunity to complete formal education, enabling disadvantaged children and youth to... 相似文献
59.
Amit Roy 《Resonance》1999,4(5):8-18
Accurate measurement of angular sizes of stars became possible with the advent of stellar interferometry pioneered by Michelson
and Pease which was limited to only the brightest giant stars. Only with the discovery of a new effect, by Hanbury Brown and
Twiss, the measurement of stellar sizes became possible for a large number of stars. This method named after them had far
reaching applications in nuclear and high energy physics. 相似文献
60.
Anmol Goyal Rajendra Prasad Parul Goel Amit Pal Suvarna Prasad Isha Rani 《Indian journal of clinical biochemistry : IJCB》2021,36(4):387
Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease. 相似文献