Genetic Polymorphisms Associated With Breast Cancer in Malaysian Cohort

Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case–control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ≤ 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.

Electronic supplementary material

The online version of this article (doi:10.1007/s12291-013-0414-0) contains supplementary material, which is available to authorized users.     

Reversible suppression of nitric oxide system in essential hypertension

Despite enormous research in the field of hypertension, its pathophysiology still remains largely unresolved and appears to be multifactorial. In the present communication, we have analyzed the status of nitric oxide (NO) in the patients with essential hypertension and age matched controls. We have found that the levels of NO are lowered in essential hypertension. The normalization of blood pressure by administration of antihypertensive therapy causes rise in the NO level indicating that perturbed NO status in essential hypertension is reversible. Addition of antioxidant to the antihypertensive drugs causes a further, though non significant, rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive drugs as adjunct in the management of essential hypertension.     

Developing theory-based,practical information literacy training for adults

Teaching librarians seeking to educate people to be lifelong, information literate learners, often employ training sessions to introduce new skill sets to patrons. To create and deliver effective training, one must first understand how training differs from traditional education, how adults learn (andragogy) in different ways than do children, and how using instructional design can yield effective, low cost information literacy programs. A wealth of on-line, open source resources is available on how to learn more about and implement training, andragogical teaching principles, and instructional design. Librarians interested in honing their teaching skills can access these resources to expand and improve their understanding of how to be better educators and trainers.     

Fibrinogen,Lp(a), Microalbuminuria and Left Ventricular Mass Index: Cardiovascular Disease Risk factors in Diabetes

The present work was undertaken to study interrelation of Fibrinogen, Lp(a) and LVMI in Type II diabetes patients with or without nephropathy. 100 Type II Diabetic patients attending OPD/IPD of DMC&H, Ludhiana were included. They were divided in two groups. Group I: 50 patients without microalbuminuria (MAU). Group II: 50 patients with MAU. Fibrinogen (Clauss method), Lp(a) and MAU were estimated on Multichannel Autoanalyzer Hitachi-911 (Roche). LVMI was estimated by echocardiography using formula of Devereux and Reicheck. Type II diabetes patients with MAU had significantly raised levels of Fibrinogen, Lp(a), and LVMI as compared to normoalbuminuric diabetics (P < 0.01). Group II patients had positive correlation between Lp(a) and LVMI but no relation between Fibrinogen and LVMI. MAU, marker of microangiopathy, is associated with higher Fibrinogen and Lp(a) levels. This becomes basis of increase cardiovascular risk as demonstrated by higher mean LVMI in Group II patients.     

A survey towards an integration of big data analytics to big insights for value-creation

Big Data Analytics (BDA) is increasingly becoming a trending practice that generates an enormous amount of data and provides a new opportunity that is helpful in relevant decision-making. The developments in Big Data Analytics provide a new paradigm and solutions for big data sources, storage, and advanced analytics. The BDA provide a nuanced view of big data development, and insights on how it can truly create value for firm and customer. This article presents a comprehensive, well-informed examination, and realistic analysis of deploying big data analytics successfully in companies. It provides an overview of the architecture of BDA including six components, namely: (i) data generation, (ii) data acquisition, (iii) data storage, (iv) advanced data analytics, (v) data visualization, and (vi) decision-making for value-creation. In this paper, seven V's characteristics of BDA namely Volume, Velocity, Variety, Valence, Veracity, Variability, and Value are explored. The various big data analytics tools, techniques and technologies have been described. Furthermore, it presents a methodical analysis for the usage of Big Data Analytics in various applications such as agriculture, healthcare, cyber security, and smart city. This paper also highlights the previous research, challenges, current status, and future directions of big data analytics for various application platforms. This overview highlights three issues, namely (i) concepts, characteristics and processing paradigms of Big Data Analytics; (ii) the state-of-the-art framework for decision-making in BDA for companies to insight value-creation; and (iii) the current challenges of Big Data Analytics as well as possible future directions.     

The design and development of a dyscalculia checklist based on a focus group interview

This article aims to explore the symptoms and characteristics of dyscalculia. This is a qualitative study. Five experts in the field of special education took part in a focus group interview. Each expert had more than ten years of experience in their area of expertise. To determine the content validity of the protocol, three experts in special education, language and qualitative research evaluated each of the eight items. Cohen's kappa analysis was used to assess inter-rater reliability. The findings of this study indicate that 59 items have been developed, based on six constructs in the dyscalculia checklist. The six constructs were subitising, estimating, Arabic numerals, verbal numbers, arithmetic facts and calculating processes. Following the focus group interview, a new construct emerged: math anxiety. The study implies that teachers might utilise this checklist to carry out early detection of students with dyscalculia in primary schools. This will enable appropriate intervention, resulting in significant benefits for the Ministry of Education, for educators and teachers, and for the students themselves. Although this study was based in Malaysia, the results have wider implications because dyscalculia is present everywhere.     

Real-time,evidence-based medicine instruction: a randomized controlled trial in a neonatal intensive care unit

Purpose: The study assesses potential for improving residents'' evidence-based medicine searching skills in MEDLINE through real-time librarian instruction.Subjects: Ten residents on a rotation in a neonatal intensive care unit participated.Methodology: Residents were randomized into an instruction and a non-instruction group. Residents generated questions from rounds and searched MEDLINE for answers. Data were collected through observation, search strategy analysis, and surveys. Librarians observed searches and collected data on questions, searching skills, search problems, and the test group''s instruction topics. Participants performed standardized searches before, after, and six-months after intervention and were scored using a search strategy analysis tool (1 representing highest score and 5 representing lowest score). Residents completed pre- and post-intervention surveys to measure opinions about MEDLINE and search satisfaction.Results: Post-intervention, the test group formulated better questions, used limits more effectively, and reported greater confidence in using MEDLINE. The control group expressed less satisfaction with retrieval and demonstrated more errors when limiting. The test and control groups had the following average search scores respectively: 3.0 and 3.5 (pre-intervention), 3.3 and 3.4 (post-intervention), and 2.0 and 3.8 (six-month post-intervention).Conclusion: Data suggest that measurable learning outcomes were achieved. Residents receiving instruction improved and retained searching skills six-months after intervention.