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91.
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Aniket Gupta Aadil Wani Anamika Joshi Haseeb Ahsan Rizwan Ahmad 《Indian journal of clinical biochemistry : IJCB》2014,29(1):63-68
Reactive oxygen species, as singlet oxygen (1O2), is continuously being generated by aerobic organisms, and react actively with biomolecules. At excessive amounts, 1O2 induces oxidative stress and shows carcinogenic and toxic effects due to oxidation of lipids, proteins and nucleic acids. In our study, immunoglobulin G (IgG) was modified by 1O2 generated by the ultraviolet (UV) irradiation of methylene blue. The modified IgG was characterized by UV spectroscopy, carbonyl content determination, thermal denaturation and electrophoretic study. Oxidation induced by modification of IgG by 1O2 also analyzed by scavenging studies. It was found that ultraviolet absorption spectra of modified IgG shows marked hyperchromicity. The carbonyl content was found to be high in modified IgG as compared to native IgG which confirms its oxidation. Thermal denaturation of modified protein sample shows decrease in Tm value by 3 °C and less intensity banding pattern on polyacrylamide gel electrophoresis. The quenching effect of sodium azide provides clue for modification of IgG by methylene blue, as it is known 1O2 scavenger. Hence, the IgG modified with 1O2 may be one of the etiological pathogenic factors for rheumatoid arthritis and diabetes. 相似文献
93.
There is controversy about whether inequalities and educational outcomes are increasing or decreasing. Using longitudinal data collected in two birth cohort studies started in 1970 and 1958 respectively, the paper examines the evidence in relation to two outcomes, probability of leaving school at 16 and highest qualification achieved. Multi-variate analysis (logistic and OLS regression) was used to model the relationships of these educational outcomes to family social class, taking account of a wide range of early life variables, including living in an urban as opposed to rural location. It is concluded that the impact of social class on educational achievement has not changed across the 12 years covered by the two studies, a result that applies in both rural and urban areas of Britain. 相似文献
94.
This study was conducted with kindergarten teachers in the United States and Japan with respect to their beliefs about the role of computers in educating young children. Overall findings indicated significant differences in responses of teachers in the two countries. Generally, U.S. teachers had a more positive attitude toward computers in educating young children, while the Japanese teachers had more concerns. The teachers’ own sense of competence with computers was not related to their beliefs about computers and young children in either country. Respondents from both countries identified a lack of resources and clear guidelines for integrating computers in the classroom as challenges. These findings highlighted the need for training of early childhood teachers in integrating and using computers in the classroom. 相似文献
95.
Andrew Klobucar Norbert Elliot Perry Deess Oleksandr Rudniy Kamal Joshi 《Assessing Writing》2013,18(1):62-84
This study investigated the use of automated essay scoring (AES) to identify at-risk students enrolled in a first-year university writing course. An application of AES, the Criterion® Online Writing Evaluation Service was evaluated through a methodology focusing on construct modelling, response processes, disaggregation, extrapolation, generalization, and consequence. Based on the results of our two-year study with students (N = 1,482) at a public technological research university in the United States, we found that Criterion offered a defined writing construct congruent with established models, achieved acceptance among students and instructors, showed no statistically significant differences between ethnicity groups of sufficient sample size, correlated at acceptable levels with other writing measures, performed in a stable fashion, and enabled instructors to identify at-risk students to increase their course success. 相似文献
96.
Indian and English Children's Understanding of the Distinction between Real and Apparent Emotion 总被引:2,自引:0,他引:2
24 preschool and 24 school-entry children in Bombay, India, and 24 preschool and 24 school-entry children in Oxford, England, were tested on their ability to distinguish between real and apparent emotion in response to stories involving child-adult and child-child interactions. Younger Indian girls did better than younger English girls, and the data reveal effects due to age, culture, gender, and story type which suggest a more social model of the understanding of emotion than has been proposed by other researchers using this methodology. 相似文献
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We present a dramatic demonstration which is also a simple, and an extremely low-cost experiment of head-on collision of two balls in a vertical direction. The advantages of this phenomenon in the vertical direction are clarified. Some simple estimates are made. A thorough analysis of this simple topic is then made, which includes various special and limiting cases, conditions of collision, change of reference frame, etc. 相似文献
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