A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

Understanding the ecology of the gastrointestinal tract and the impact of the contents on the host mucosa is emerging as an important area for defining both wellness and susceptibility to disease. Targeted delivery of drugs to treat specific small intestinal disorders such as small bowel bacterial overgrowth and targeting molecules to interrogate or to deliver vaccines to the remote regions of the small intestine has proven difficult. There is an unmet need for methodologies to release probes/drugs to remote regions of the gastrointestinal tract in furthering our understanding of gut health and pathogenesis. In order to address this concern, we need to know how the regional delivery of a surrogate labeled test compound is handled and in turn, if delivered locally as a liquid or powder, the dynamics of its subsequent handling and metabolism. In the studies we report on in this paper, we chose ¹³C sodium acetate (¹³C-acetate), which is a stable isotope probe that once absorbed in the small intestine can be readily measured non-invasively by collection and analysis of ¹³CO₂ in the breath. This would provide information of gastric emptying rates and an indication of the site of release and absorptive capacity. In a series of in vitro and in vivo pig experiments, we assessed the enteric-protective properties of a commercially available polymer EUDRAGIT®L100-55 on gelatin capsules and also on DRcaps®. Test results demonstrated that DRcaps®coated with EUDRAGIT®L100-55 possessed enhanced enteric-protective properties, particularly in vivo. These studies add to the body of knowledge regarding gastric emptying in pigs and also begin the process of gathering specifications for the design of a simple and cost-effective enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.     

Inconsistency of decision-making,the Achilles heel of referees

This study assessed whether decisions made by six qualified referees were consistent when watching the live 2016 televised Champions League Final. Referees were paired off into three separate rooms. Two referees watched the game with no supporters present. Two watched the game surrounded by Real Madrid supporters, and the remaining two watched the game surrounded by Athletic Madrid supporters. Referees were asked to decide whether each decision made by the on-field referee was either correct or incorrect. Results identified two types of refereeing inconsistency. The first type was a systematic tendency of the supporting crowds (both rooms) to influence the adjudicating referees to make fewer incorrect (disagree with the on-field referee) decisions (8 and 5) than referees in the “no supporters” room (19) (χ² = 11.22 [df = 2], P = 0.004). The second type of inconsistency was the home advantage “bias”, where the surrounding crowd influenced the adjudicating referees to favour their team, by disagreeing with the decision made by the on-field referee (χ² = 6.0 [df = 2], P = 0.0498). One explanation for these inconsistencies is that referees adopt a coping strategy of “avoidance”, i.e., when faced with difficult decisions, referees simply avoid making unpopular decisions by waving “play on”.     

From cohort to community in a preservice teacher education program

It is often suggested that student teachers be placed in cohorts during their preservice program. In this paper we describe how we implemented a cohort model and examine the effects on our student teachers. We found there were many positive effects, such as a high level of participation in whole class and small group activities, greater awareness of the value of collaboration, and greater willingness to take risks in collegial relationships and in the practicum. However, the approach proved to be quite demanding for the faculty; strong institutional support will be needed if the model is to be widely implemented.     

Fostering multiliteracies pedagogy through preservice teacher education

Teacher education for literacy teaching is often fairly narrow in focus. New approaches are needed that are sociocultural in orientation and take due account of the diversity of language forms, both traditional and contemporary, formal and informal, literary and non‐literary. We believe this need can be met by largely adopting a ‘multiliteracies’ approach as articulated by the New London Group. This research examined the ideas and practices of 10 literacy faculty in a large school of education and 22 first year literacy teachers from the same institution. It found that despite some important advances in a multiliteracies direction, many shortcomings remained. Part of the difficulty was lack of clarity about the nature and purpose of multiliteracies pedagogy. This paper has two main purposes: first, to attempt to clarify the nature and importance of a multiliteracies approach; and second, to report on the successes achieved and challenges encountered in moving in this direction in one school of education.     

How do you teach learning?

The question ‘How do you teach ‘learning'?’ is located within the domain of professional adult education practice and is dealt with through a series of ‘stock‐taking’ moves through the field of practice. First, we offer a high‐level overview of standard answers to the question imbedded in contemporary educational practice. Second, we examine the adult education case in particular, focussing on the peculiarly idealised role the ‘adult learner’ has come to assume in international practitioner discourse. Third, we narrow the focus sharply to present a brief case‐study of our own attempts to teach ‘learning’ within the Advanced Diploma Course for Educators of Adults at the University of Cape Town. Finally, we attempt to clarify our present assumptions about the requirements of a ‘curriculum for learning’. (1) 1. An earlier version of this paper was presented at the Kenton Educational Conference, University of the Witwatersrand, Johannesburg, South Africa, in November 1992.

     

The Learner's Prior Knowledge: a Critical Review of Techniques for Probing its Organization

Science education is presented as the negotiation of knowledge between several different perspectives: those provided by ‘scientists’ science’, ‘ curricular science’, ‘teachers’ science’, ‘children's science’ and ‘students’ science’. A case study based on concepts of force and movement is used to illuminate these perspectives, and implications for the curricular presentation and classroom teaching of the ideas are discussed.