基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例

[目的/意义]通过构建二模复杂网络模型,揭示隐藏在海量文献中的隐性知识。[方法/过程]通过NetworkX复杂网络工具包,依据任意两个节点的共现关系构建二模复杂网络模型;对网络模型中节点的共现关系进行加权,计算网络的拓扑信息并进行AP聚类,提取节点间的直接关系;采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价,遴选出最合适的预测算法,并对复杂网络的隐性关系进行预测分析。[结果/结论]以潜在药物靶点挖掘为例进行的实证研究结果表明,wAA链路预测算法为最优的链路预测算法;二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试,以进一步验证该模型的通用性和有效性。     

Reading expressively and understanding thoroughly: An examination of prosody in adults with low literacy skills

The purpose of the current study was to explore the relationship between prosody, which is the expressive quality of reading out loud, and reading comprehension in adults with low literacy skills compared to skilled readers. All participants read a passage orally, and we extracted prosodic measures from the recordings. We examined pitch changes and how long readers paused at various points while reading. Finally, for the adults with low literacy skills, we collected information on decoding, word recognition, and reading comprehension. We found several interesting results. First, adults with low literacy skills paused longer than skilled readers and paused at a substantially greater number of punctuation marks. Second, while adults with low literacy skills do mark the end of declarative sentences with a pitch declination similar to skilled readers, their readings of questions lack a change in pitch. Third, decoding and word recognition skills were related to pauses while reading; readers with lower skills made longer and more frequent and inappropriate pauses. Finally, pausing measures explained a significant amount of variance in reading comprehension among the adults with low literacy skills.     

The status of training and performance research in the AECT journals

“HPT has had a significant impact on the instructional design and technology field.” Cynthia Conn is working on her Ph.D. in educational technology at the University of Northern Colorado Jacqueline Gitonga is currently working on her Ph.D. in human resource education at the University of Illinois at Urbana-Champaign. Her research interests are in training and development, instructional design and human performance technology.     

Why We Watch: Factors Affecting Exposure to Tragic Television News

This study explored the reasons people expose themselves to news depicting tragic events. A total of 376 undergraduates completed anonymous questionnaires about their responses to news coverage of the events of September 11. The study examined the extent to which individual differences in empathy gave rise to news viewing motives (surveillance, reassurance, curiosity), and how these variables, as well as negative emotional responses (anger, sadness, fear), were related to news interest and exposure. Both empathy and emotional responses were associated in predictable ways with interest in news coverage and selective exposure to specific types of news stories (e.g., casualty news, positive news). The results demonstrate that considering affective motivations can enrich our understanding of how and why people use news media. Limitations and suggestions for future research are discussed.     

“We Do It,but They Don't”: Multiple Categorizations and Work Team Communication

The present study adopted an intergroup approach to information sharing and ratings of work team communication in a public hospital (N?=?142) undergoing large-scale restructuring. Consistent with predictions, ratings of communication followed a double ingroup serving bias: while team members reported sending about the same levels of information to double ingroup members (same work team/same occupational group) as they did to partial ingroup members (same work team/different occupational group), they reported receiving less information from partial ingroup members than from double ingroup members and rated the communication that they received from partial ingroup members as less effective. We discuss the implication of these results for the management of information sharing and organizational communication.     

Attachment and Adolescent Psychosocial Functioning

To explore the meaning and function of attachment organization during adolescence, its relation to multiple domains of psychosocial functioning was examined in a sample of 131 moderately at-risk adolescents. Attachment organization was assessed using the Adult Attachment Interview; multiple measures of functioning were obtained from parents, adolescents, and their peers. Security displayed in adolescents' organization of discourse about attachment experiences was related to competence with peers (as reported by peers), lower levels of internalizing behaviors (as reported by adolescents), and lower levels of deviant behavior (as reported by peers and by mothers). Preoccupation with attachment experiences, seen in angry or diffuse and unfocused discussion of attachment experiences, was linked to higher levels of both internalizing and deviant behaviors. These relations generally remained even when other attachment-related constructs that had been previously related to adolescent functioning were covaried in analyses. Results are interpreted as suggesting an important role for attachment organization in a wide array of aspects of adolescent psychosocial development.     

Session - 3 December 19, 2007 Cardiovascular risk markers - II

Oral Cancer is one of the five leading sites of cancer in Indian population. The circulating immune complexes were investigated in 100 serum samples of 60 oral cancer patients having different grades of the disease and 40 patients with precancerous lesions obtained from Nair Hospital Dental collage, Mumbai. The results obtained were compared with those of group of 40 healthy blood donors. Elevated levels of Circulating Immune Complexes were observed in oral cancer patients and patients with oral precancerous lesions. 92% positive samples were observed in well differentiated squamous cell carcinoma whereas 100% positive samples were observed in both moderately and poorly differentiated squamous cell carcinoma. Oral leukoplakia and oral submucous fibrosis showed 15% and 90% positivity respectively. Increased level of Circulating Immune complexes in high grade tumor suggest that Circulating Immune complexes is likely to contribute in evaluating the degree of malignancy, but follow up study is needed to draw any conclusion regarding it's prognostic role     

Test-Enhanced Learning: The Potential for Testing to Promote Greater Learning in Undergraduate Science Courses

Testing within the science classroom is commonly used for both formative and summative assessment purposes to let the student and the instructor gauge progress toward learning goals. Research within cognitive science suggests, however, that testing can also be a learning event. We present summaries of studies that suggest that repeated retrieval can enhance long-term learning in a laboratory setting; various testing formats can promote learning; feedback enhances the benefits of testing; testing can potentiate further study; and benefits of testing are not limited to rote memory. Most of these studies were performed in a laboratory environment, so we also present summaries of experiments suggesting that the benefits of testing can extend to the classroom. Finally, we suggest opportunities that these observations raise for the classroom and for further research.Almost all science classes incorporate testing. Tests are most commonly used as summative assessment tools meant to gauge whether students have achieved the learning objectives of the course. They are sometimes also used as formative assessment tools—often in the form of low-stakes weekly or daily quizzes—to give students and faculty members a sense of students’ progression toward those learning objectives. Occasionally, tests are also used as diagnostic tools, to determine students’ preexisting conceptions or skills relevant to an upcoming subject. Rarely, however, do we think of tests as learning tools. We may acknowledge that testing promotes student learning, but we often attribute this effect to the studying students do to prepare for the test. And yet, one of the most consistent findings in cognitive psychology is that testing leads to increased retention more than studying alone does (Roediger and Butler, 2011 ; Roediger and Pyc, 2012 ). This effect can be enhanced when students receive feedback for failed tests and can be observed for both short-term and long-term retention. There is some evidence that testing not only improves student memory of the tested information but also ability to remember related information. Finally, testing appears to potentiate further study, allowing students to gain more from study periods that follow a test. Given the potential power of testing as a tool to promote learning, we should consider how to incorporate tests into our courses not only to gauge students’ learning, but also to promote that learning (Klionsky, 2008 ).We provide six observations about the effects of testing from the cognitive psychology literature, summarizing key studies that led to these conclusions (see

Changes in children’s anger,sadness, and persistence across blocked goals: Implications for self-regulation

The current study took a person-centered approach to examine the heterogeneity of changes in children’s emotions and persistence during a goal-blocking task and examined how different profiles of emotions and persistence related to children’s self-regulation. Children’s anger, sadness, and persistence were rated in a goal-blocking task in toddlerhood (T1; N = 140, 72 boys, M_age = 2.67 years, 90.7% White) and preschool (T2). Children’s self-regulation, specifically sustained attention and engagement, was assessed at T1, T2, and early school-age (T3) from 2005 to 2012. Growth mixture modeling revealed two classes of children at T1 and three classes at T2 with different patterns of anger, sadness, and persistence. Children’s classification at T2, but not T1, significantly predicted their sustained attention and engagement both concurrently and longitudinally.