进一步规范和完善大学生就业服务体系

高校毕业生就业所面临的形势日趋严峻,已引起各级政府和各类高校的普遍重视,如何进一步规范和完善大学生就业服务体系具有重大的现实意义,通过加快高校就业信息网的建设,建立完善法律法规教育咨询服务体系,加强诚信教育等来进一步拓展大学生就业指导工作。     

西方视角下的东方神话——解读赛珍珠的《大地》

赛珍珠的《大地》是一个独特的文化现象。它是西方视角与中国精神的奇妙结合，作者采用了适度“神话”的方式来对待中国历史。同时，在小说艺术手法上，赛珍珠采用“奇迹”的写作方式和与生活真实适当疏离的方法营造一种传奇色彩，曲折地反映了作者的审美理想。这种写作态度集中体现在对主人公王龙三次婚姻生活的描写上。     

The relationship between parental bonding and peer victimization: examining child stress and hopelessness as mediators

The purpose of the current study was to investigate a two-stage model in which parent-related stress and hopelessness each served as mediators of the relationship between perceived parental bonding and South Korean adolescent peer victimization. This study also examined whether the mediating relationships differed by the gender of parents and adolescents. A casual chain with three links and four sets of variables were analyzed using structural equation modeling. Data were collected from 800 adolescents attending 10 middle schools in the Busan region of South Korea. Results indicated that both maternal and paternal parental bonding were negatively associated with stress, stress was positively associated with hopelessness, and hopelessness was positively associated with South Korean adolescent peer victimization. Most importantly, the significant negative associations between both maternal and paternal parental bonding and peer victimization were mediated by both stress and hopelessness. Furthermore, gender differences in these relationships existed for both parents and adolescents. Limitations and implications to practice were discussed.     

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein

Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding cassette (ABC) transporter, is high in tumor cells, resulting in their resistance to a variety of cytotoxic drugs. However, the function of LRP in tumor drug resistance is not yet explicit. Our previous studies had shown that Kinesin KIF4A was overexpressed in cisplatin (DDP)-resistant human lung adenocarcinoma cells (A549/DDP cells) compared with A549 cells. The expression of KIF4A in A549 or A549/DDP cells significantly affects cisplatin resistance but the detailed mechanisms remain unclear. Here, we performed co-immunoprecipitation experiments to show that the tail domain of KIF4A interacted with the N-terminal of LRP. Immunofluorescence images showed that both the ability of binding to LRP and the motility of KIF4A were essential for the dispersed cytoplasm distribution of LRP. Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane. Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.     

校本课程发展与教育行动研究

校本课程发展(school based curriculum development)与教育行动研究(educational actionresearch),在许多方面都有相似或共通之处。在某些地方,如英国,校本课程发展与教育行动研究的涌现与发展是紧密交织在一起的(Elliot,1997,陈惠邦,1998)。探讨校本课程发展与教育行动研究的关系,尤其是,校本课程发展中的哪些问题,可以通过教育行动研究的引进得到较好的解决,是很有价值的一个课题。     

谈谈投标的施工组织设计

通过对投标施工组织设计作用及特点的分析，阐述了投标施工组织设计在招投标过程中的重要性并指出了投标施工组织设计编制过程中一些经常易被忽视的重要问题。目的在于引导读者如何编制好投标施工组织设计文件。     

DNA甲基化异常与肿瘤发生的研究

DNA甲基化是真核生物DNA的正常内源性修饰方式 ,它由DNA甲基化转移酶催化发生。但DNA甲基化异常在肿瘤发生中却起着极为重要的作用 ,它主要表现为抑癌基因高甲基化所致的基因失活和原癌基因低甲基化所致的基因激活 ,引起与细胞增殖、分化相关基因表达异常 ,造成细胞恶变形成肿瘤。文章总结了DNA甲基化异常对肿瘤相关基因表达的影响 ,在肿瘤发生中的可能机制及针对高甲基化的治疗方案     

论"合作学习"

合作学习是当前课程改革中倡导的三大学习方式之一,它对于培养学生的合作精神,发展交往与独立思维的能力,拓展学生知识渠道,实施因材施教等,具有积极的促进作用。     

美国高校学术科研信息公开的原则、标准及路径

科学研究是高校自治中的重要内容,也是自治程度最高的领域。同政府信息公开相比,学术科研信息适用推定公开原则的范围较窄,其是否公开涉及的因素更多,公开范围的确定和划分更加复杂。从学术科研信息公开范围来看,美国大学信息公开制度主要从信息公开时间节点、信息种类、所涉利益的轻重缓急等多个维度出发,制定了一套易于实施操作的分类划分标准,很好的处理了学术自治与信息公开之间的矛盾,在保证信息公开的同时维护了相关利益者的权益。通过案例分析,对美国学术科研信息公开制度进行了深入探讨,对信息分类方法、标准和原则等进行了讨论,为我国学术科研信息公开提供有益经验。     

建设学习型社会和组织是创新战略的重要组成部分

奥地利裔美籍经济学家熊比特(JosephSchumpeter,1883—1950)的创新理论属于经济学范畴,它作为与德国思想家和经济学家马克思(Karl Marx,1818—1883)的理论和英国经济学家凯恩思(John Maynard Keynes,1883—1946)的理论相对立的理论,以新生产函数的产生解释资本主义经济的增长。但它的发展逐渐超越了其原始意义,由于发展到国家创新系统研究而涉及到人类社会的全面发展问题。他赋予创新以“创造性的毁灭”的思想,按照中国文化传统可以理解为革故鼎新、除旧布新和破旧立新,可以使之拓展到整个人类社会生活领域。在这个意义上我们可以讨论人…