Spelling well despite developmental language disorder: what makes it possible?

The goal of the study was to investigate the overlap between developmental language disorder (DLD) and developmental dyslexia, identified through spelling difficulties (SD), in Russian-speaking children. In particular, we studied the role of phoneme awareness (PA), rapid automatized naming (RAN), pseudoword repetition (PWR), morphological (MA), and orthographic awareness (OA) in differentiating between children with DLD who have SD from children with DLD who are average spellers by comparing the two groups to each other, to typically developing children as well as children with SD but without spoken language deficits. One hundred forty-nine children, aged 10.40 to 14.00 years, participated in the study. The results indicated that the SD, DLD, and DLD/SD groups did not differ from each other on PA and RAN Letters and underperformed in comparison to the control groups. However, whereas the children with written language deficits (SD and DLD/SD groups) underperformed on RAN Objects and Digits, PWR, OA, and MA, the children with DLD and no SD performed similarly to the children from the control groups on these measures. In contrast, the two groups with spoken language deficits (DLD and DLD/SD) underperformed on RAN Colors in comparison to the control groups and the group of children with SD only. The results support the notion that those children with DLD who have unimpaired PWR and RAN skills are able to overcome their weaknesses in spoken language and PA and acquire basic literacy on a par with their age peers with typical language. We also argue that our findings support a multifactorial model of DLD.     

UpToDate versus DynaMed: a cross-sectional study comparing the speed and accuracy of two point-of-care information tools

Objective:To compare the accuracy, time to answer, user confidence, and user satisfaction between UpToDate and DynaMed (formerly DynaMed Plus), which are two popular point-of-care information tools.Methods:A crossover study was conducted with medical residents in obstetrics and gynecology and family medicine at the University of Toronto in order to compare the speed and accuracy with which they retrieved answers to clinical questions using UpToDate and DynaMed. Experiments took place between February 2017 and December 2019. Following a short tutorial on how to use each tool and completion of a background survey, participants attempted to find answers to two clinical questions in each tool. Time to answer each question, the chosen answer, confidence score, and satisfaction score were recorded for each clinical question.Results:A total of 57 residents took part in the experiment, including 32 from family medicine and 25 from obstetrics and gynecology. Accuracy in clinical answers was equal between UpToDate (average 1.35 out of 2) and DynaMed (average 1.36 out of 2). However, time to answer was 2.5 minutes faster in UpToDate compared to DynaMed. Participants were also more confident and satisfied with their answers in UpToDate compared to DynaMed.Conclusions:Despite a preference for UpToDate and a higher confidence in responses, the accuracy of clinical answers in UpToDate was equal to those in DynaMed. Previous exposure to UpToDate likely played a major role in participants'' preferences. More research in this area is recommended.     

New projects in particle physics

Recent results in the field of particle physics raise many questions on the elementary constituents of matter and their interactions. These cannot be answered, nor the latest theoretical predictions verified, without accelerators operating at higher energies. Pending world-wide collaboration for the construction of a gigantic accelerator, individual nations are engaged in an increasingly competitive race to construct such machines. The author describes the main assemblies under construction or currently planned in Western Europe, the USA and the USSR, and discusses the technical, financial, political, and, by no means least, human problems involved.     

Can public arts education replace arts subsidization?

The debate about whether the arts should be supported or not is far from new, and most governments support the arts in one way or the other. The literature considers several arguments in favor of such interventions. Public education may seem to be an action which could, in the long run, lead to possible reductions of subsidies. Surveys show that those who have been exposed to the arts when young participate more when adult. However, the “non-market” transmission from parents to children generates an external effect, which has to be taken into account to reach first-best situations. We construct an overlapping generations model in which young consumers are exposed to both public education toward the arts and to non-altruistic transmission of such a taste from their parents. We show that the first-best can be reached only if there is both public cultural education and subsidization of arts consumption. Therefore, education cannot be considered as a substitute for subsidies to arts consumption. However, as is often the case in European countries, government intervention is usually below the first-best level. Using a model calibrated on French data, we show that it is then preferable to subsidize education, while consumption, especially of the older generations, should be taxed rather than subsidized.

The impact of microfluidics in high-throughput drug-screening applications

Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin preclinical tests proceed to clinical trials. Indeed, current high-throughput screening technologies are very expensive, as they are unable to dispense small liquid volumes in an accurate and quick way. Moreover, despite being simple and fast, drug screening assays are usually performed under static conditions, thus failing to recapitulate tissue-specific architecture and biomechanical cues present in vivo even in the case of 3D models. On the contrary, microfluidics might offer a more rapid and cost-effective alternative. Although considered incompatible with high-throughput systems for years, technological advancements have demonstrated how this gap is rapidly reducing. In this Review, we want to further outline the role of microfluidics in high-throughput drug screening applications by looking at the multiple strategies for cell seeding, compartmentalization, continuous flow, stimuli administration (e.g., drug gradients or shear stresses), and single-cell analyses.     

The relationships between pelvic range of motion,step width and performance during an athletic sprint start

ABSTRACT

The aims of this study were (a) to describe the kinematics underlying the phenomenon of the knee of the swing leg passing medially in front of the athlete during the single push (SP) phase of the block sprint start, and (b) to determine the relationships between block phase pelvis range of motion (RoM), 1^st step width and block phase performance. Three-dimensional kinematic data (250 Hz) were collected from eleven competitive sprinters (100 m PB: 11.17 ± 0.41) performing maximal effort block starts. The joint angles of the rear hip with respect to the pelvis and the pelvis segment angles with respect to the laboratory coordinate system were calculated during the block start phase to the end of the 1^st stance. A combination of pelvis list and rotation (not hip adduction) was coupled with the thigh of the swing leg moving medially during the SP phase. A very high positive correlation was found between pelvic list RoM and 1^st step width (r = 0.799, p = 0.003). No other significant correlations were found. Attempting to reduce pelvic RoM or changing frontal and transverse plane hip joint angles to minimise medial thigh motion is unlikely to lead to an improvement to performance.     

Exploring the Relationships between Employee Burnout,Organizational Dissent and Work-family Culture in Russian Organizations

ABSTRACT

Employees who fail to balance work and life responsibilities are likely to experience job burnout and, ultimately, withdraw their engagement and voice in the workplace. The current study explored the relationships between employee burnout, work-family balance, and organizational dissent. More importantly, these relationships were tested in an under-researched and culturally unique context, Russia. Data collected from 232 full-time employees in the Perm region were analysed using multiple regression analysis. Analysis revealed that employee burnout is negatively related to articulated dissent and positively related to latent dissent. Furthermore, employees who receive managerial support for prioritizing family issues are less likely to experience job burnout. The influences of national culture and macroeconomic factors on the tested relationships are further discussed