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501.
RESEARCH REPORT     
The study explores teachers’ experiences of teaching a context‐based chemistry course, Salters Advanced Chemistry, as compared with teachers of a conventional course. Second, main factors that appear to influence decisions over whether or not to adopt context‐based courses are investigated. Two hundred and twenty‐two teachers’ views of a context‐based and a conventional school advanced chemistry course were obtained from a questionnaire. Responses were analysed in six dimensions: motivation, chemical knowledge and development of concepts, learning activities, assessment, challenge to teachers and students, and teacher support. Both sets of teachers agreed that the context‐based course is more motivating to study and teach, that students would be more interested in chemistry and more likely to go to university to study chemistry, that students would be better able to study independently but that it is more demanding to teach and study. The groups differed principally about concept development and teaching strategy. The context‐based teachers believed that their course gave as good a foundation for further study as a traditional course and that the spiral curriculum was advantageous. Conventional course teachers disagreed with both statements. One significant implication to emerge from the study is the crucial role played by in‐service support in influencing the impact of a curriculum innovation.  相似文献   
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The Learning Consortium has provided the conditions for Consortium partners to construct a more meaningful approach to instructional change. Those conditions focus on four opportunities: (1) to build on individual accomplishments; (2) to create a broader view of the educational picture; (3) to share and interact with wider audiences; and (4) to re‐focus on the future. This article applies those conditions to illustrate the Durham Board of Education's efforts to extend the instructional practices of their teachers. The major message is that extending the instructional practices of teachers requires an intensive effort over time.  相似文献   
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Background:Obesity increases knee osteoarthritis(OA) risk through metabolic,inflammatory,and biomechanical factors,but how these systemic and local mediators interact to drive OA pathology is not well understood.We tested the effect of voluntary running exercise after chronic diet-induced obesity on knee OA-related cartilage and bone pathology in mice.We then used a correlation-based network analysis to identify systemic and local factors associated with early-stage knee OA phenotypes among the different diet and exercise groups.Methods:Male C57 BL/6 J mice were fed a defined control(10% kcal fat) or high fat(HF)(60% kcal fat) diet from 6 to 37 weeks of age.At 25 weeks,one-half of the mice from each diet group were housed in cages with running wheels for the remainder of the study.Histology,micro computed tomography,and magnetic resonance imaging were used to evaluate changes in joint tissue structure and OA pathology.These local variables were then compared to systemic metabolic(body mass,body fat,and glucose tolerance),inflammatory(serum adipokines and inflammatory mediators),and functional(mechanical tactile sensitivity and grip strength) outcomes using a correlation-based network analysis.Diet and exercise effects were evaluated by two-way analysis of variance.Results:An HF diet increased the infrapatellar fat pad size and posterior joint osteophytes,and wheel running primarily altered the subchondral cortical and trabecular bone.Neither HF diet nor exercise altered average knee cartilage OA scores compared to control groups.However,the coefficient of variation was≥25% for many outcomes,and some mice in both diet groups developed moderate OA(>33% maximum score).This supported using correlation-based network analyses to identify systemic and local factors associated with early-stage knee OA phenotypes.In wheel-running cohorts,an HF diet reduced the network size compared to the control diet group despite similar running distances,suggesting that diet-induced obesity dampens the effects of exercise on systemic and local OA-related factors.Each of the 4 diet and activity groups showed mostly unique networks of local and systemic factors correlated with early-stage knee OA.Conclusion:Despite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations,diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA.These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease.  相似文献   
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The recent wave of reform reports in education promulgated a wide variety of recommendations to address identified concerns. This research explores an issue mostly ignored by the reform reports, the working conditions teachers face. Utilizing ethnographic techniques and multisite analyses of in-depth case studies of six schools in two large urban areas, the authors identify five broad categories of stressors in the work environment, including governance/leadership, budget cuts, security, staff relations, and student issues. In addition, two major themes characterizing working conditions for teachers are specified, the no respect syndrome and barriers to teaching. The need to address these issues before attempting to implement the major reforms in the national reports is highlighted.  相似文献   
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