Acid base status in chronic obstructive pulmonary disease patients

348 patients of chronic obstructive pulmonary diseases (COPD) were studied for their acid base profile using ABL-3 blood gas analyser (Radiometer, copenhagan). 185 patients (53.1%) had simple disorders (respiratory acidosis—53%, respiratory alkalosis—25.4%, metabolic acidosis—11.3%, metabolic alkalosis—10.2%). Mixed disorders were present in 131 patients (34.9%) (respiratory acidosis and metabolic acidosis—75.2%, respiratory acidosis and metabolic acidosis—14%, metabolic acidosis and metabolic alkalosis—5.7%, metabolic alkalosis and respiratory alkalosis—4.9%). Hypoxemia without other acid base abnormalities was observed in early patients of GOPD (42 patients—12%). Chronic respiratory acidosis was the most common finding in advanced cases of COPD (98%). An almost equal number of such patients had a mixed disorder of respiratory acidosis with metabolic alkalosis (91%). Salt restriction, prolonged use of steriods and hypokalemia were often related to metabolic alkalosis in such patients.     

Gaining benefits from IS/IT implementation: Interpretations from case studies

This paper examines those contextual issues that determine the success of a computer-based information system. It shows that a narrow technology-focused orientation in systems development is a limiting factor in realizing benefits. In doing so it argues that real benefits reside not within the IT domain but instead in the changes in the organizational activities that the IT system has enabled. The paper reviews such benefits through two information system implementation case studies.     

Evidence and benefits of postgraduate international students-staff members partnership in extra-curricular activities: a Malaysian perspective

ABSTRACT

The student engagement concept has been revolutionised so that students play an active role alongside staff members in determining their student learning experiences. Although the development of student–staff partnerships enhances student engagement and experience, empirical research on partnerships in Malaysia is scant. This paper contributes to the growing scholarly literature on such partnerships – in particular, exploring postgraduate international students and staff members’ partnership dimensions in extra-curricular activities at a research university in Malaysia. This qualitative study interviewed 33 postgraduate international students, 10 academic staff and 12 professional staff members. Based on the findings, the student–staff partnership model is well integrated into the extra-curricular activities: international students are invited to co-design and implement adjustment programmes for newly arrived international students. This paper also explores the multi-layered benefits of partnerships for postgraduate international students and for staff members. The implications of such partnerships for the university, international students and staff members are discussed.     

Resilience in Context: A Brief and Culturally Grounded Measure for Syrian Refugee and Jordanian Host‐Community Adolescents

Validated measures are needed for assessing resilience in conflict settings. An Arabic version of the Child and Youth Resilience Measure (CYRM) was developed and tested in Jordan. Following qualitative work, surveys were implemented with male/female, refugee/nonrefugee samples (N = 603, 11–18 years). Confirmatory factor analyses tested three‐factor structures for 28‐ and 12‐item CYRMs and measurement equivalence across groups. CYRM‐12 showed measurement reliability and face, content, construct (comparative fit index = .92–.98), and convergent validity. Gender‐differentiated item loadings reflected resource access and social responsibilities. Resilience scores were inversely associated with mental health symptoms, and for Syrian refugees were unrelated to lifetime trauma exposure. In assessing individual, family, and community‐level dimensions of resilience, the CYRM is a useful measure for research and practice with refugee and host‐community youth.     

Gender Differences in Mathematics Attainment of Singaporean Pupils

This study compares the performance of Singapore boys and girls in Ordinary (‘O’) level Mathematics (Syllabus D). A sample of 88 boys and 88 girls was used to identify some areas of concern as regards gender and Mathematics attainment. The findings of the study were as follows:

• (i) Boys performed better than girls on Paper I questions.

• (ii) For the compulsory questions on both papers boys did significantly better than the girls on the following topics – mensuration, statistics, arithmetic, geometry and probability while the girls out-performed the boys on algebra and graphs.

• (iii) Boys also surpassed girls on the compulsory questions which tested spatial ability.

• (iv) In Paper II, section B, girls showed a marked preference for questions on algebra and graphs, and vectors in two dimensions while the boys' only marked preference was the question on mensuration.

The pupils' grades in Mathematics were also compared with those of the other subjects they took in the English medium examination and it was found that grades in Physics, Science (Chemistry, Physics) and Metalwork – the so called Mathematics-related subjects – did not correlate to the same degree for the two sexes.

The Mathematics results of the Singapore candidature in ‘O’ level Mathematics examination revealed that on the whole boys performed better than girls.     

Scientific discovery and topological transitions in collaboration networks

We analyze the advent and development of eight scientific fields from their inception to maturity and map the evolution of their networks of collaboration over time, measured in terms of co-authorship of scientific papers. We show that as a field develops it undergoes a topological transition in its collaboration structure between a small disconnected graph to a much larger network where a giant connected component of collaboration appears. As a result, the number of edges and nodes in the largest component undergoes a transition between a small fraction of the total to a majority of all occurrences. These results relate to many qualitative observations of the evolution of technology and discussions of the “structure of scientific revolutions”. We analyze this qualitative change in network topology in terms of several quantitative graph theoretical measures, such as density, diameter, and relative size of the network's largest component.To analyze examples of scientific discovery we built databases of scientific publications based on keyword and citation searches, for eight fields, spanning experimental and theoretical science, across areas as diverse as physics, biomedical sciences, and materials science. Each of the databases was vetted by field experts and is the result of a bibliometric search constructed to maximize coverage, while minimizing the occurrence of spurious records. In this way we built databases of publications and authors for superstring theory, cosmic strings and other topological defects, cosmological inflation, carbon nanotubes, quantum computing and computation, prions and scrapie, and H5N1 influenza. We also built a database for a classical example of “pathological” science, namely cold fusion. All these fields also vary in size and in their temporal patterns of development, with some showing explosive growth from an original identifiable discovery (e.g. carbon nanotubes) while others are characterized by a slow process of development (e.g. quantum computers and computation).We show that regardless of the detailed nature of their developmental paths, the process of scientific discovery and the rearrangement of the collaboration structure of emergent fields is characterized by a number of universal features, suggesting that the process of discovery and initial formation of a scientific field, characterized by the moments of discovery, invention and subsequent transition into “normal science” may be understood in general terms, as a process of cognitive and social unification out of many initially separate efforts. Pathological fields, seemingly, never undergo this transition, despite hundreds of publications and the involvement of many authors.     

Changing state–university relations: the experiences of Japan and lessons for Malaysia

This article investigates the changing state–university relations in Japan and Malaysia. Its main objective is to identify and examine possible lessons for Malaysia, based on the Japanese experience. Notably, since the late 1970s, Malaysia has been looking towards Japan as a model for socio‐economic development (the ‘look‐east’ Policy) and this article was written with the same underlying thrust. Of particular interest in this article is the Japanese experience with the Incorporation of National Universities in 2004. Malaysia has corporatised all state‐controlled universities since 1998 but has stopped short of implementing the kind of institutional autonomy, which resulted in precarious state–university relations in Japan. Based on the situation in Japan with regard to incorporation of national universities, what steps should Malaysia take in order to develop a higher education system and higher education institutions that are comparable to that of matured higher education systems?     

Hypocalcemia Presenting as Life Threatening Torsades de Pointes with Prolongation of QTc Interval

Torsades de pointes with prolonged QTc interval is a form of ventricular tachycardia. Many predisposing factors have been identified and hypocalcemia is among the rare ones. Our case illustrates that though rare, hypocalcemia might manifest as torsades de pointes with prolongation of QTc interval. Early diagnosis and management of dyselectrolytemia can prevent these patients from catastrophic torsades de pointes.     

Can High Titres of Anti Tissue Transglutaminase Antibodies Reduce the Need for Intestinal Biopsy for Diagnosis of Celiac Disease?

Traditionally small intestinal biopsy has been considered a gold standard for the diagnosis of celiac disease (CD). But now data has shown that serological markers like anti-tissue-transglutaminase antibodies (tTGA) can be used to make the diagnosis with great sensitivity and specificity. The objective of the present study was to evaluate whether patients with high probability of CD and high titre of tTGA, have a high probability of intestinal damage and may not require biopsy for final diagnosis. All the cases with tTGA levels ≥15 IU/ml and who subsequently underwent biopsy from July 2010 to June 2013 were selected. Histopathological findings graded as per Marsh classification were correlated with serum tTGA levels. Grade 3 lesions were considered diagnostic for the disease. Out of total 731 patients 470 had serum tTGA levels >100 IU/ml and 261 patients had <100 IU/ml. Highest levels of tTGA (219.3 IU/ml) were seen in grade 3c which was >12 times the normal cutoff value. Mean serum tTGA in higher histological grade i.e. 3 (3a, 3b, 3c) was 186.7 IU/ml (>12 times the normal cut off value) as compared to grade 1 which was 108.9 IU/ml (>7 times the normal cut off value). Using a tTGA cutoff value of 70 IU/ml, sensitivity was found to be 83.9% while specificity was 56.10% with an overall accuracy of 77.7%. This study confirms that a small intestinal biopsy is not always necessary for the diagnosis of CD in symptomatic patients with high tTGA levels (>70 IU/ml).     

Considering the ethical implications of social media in social work education

The ethical implications of the explosion of social media outlets for social work education are explored in this paper. Given that social work education has a dual focus, both of educating students and of socializing practitioners into the profession, the issue of the blurring between what is social and what is professional gains particular salience for both educators and students. Recommendations for educators to ethically address the need to maintain a consistent professional presence online and to avoid potentially harmful dual relationships with students are presented. These recommendations include: abstain from using social media or use only a static professional profile; use only university protected sites to promote collaboration with students in the classroom including all students to avoid any appearance of impropriety; use social media with the utmost discretion mindful of all the risks by creating a very select circle of friends, separating one’s personal site from one’s professional site; develop policies which include not friending any individual student or any current student and inform students about the policies.