Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.     

The e-balanced scorecard (e-BSC) for measuring academic staff performance excellence

This research paper is a pilot study that investigated the suitability of adopting an automated balanced scorecard for managing and measuring the performance excellence of academic staffs in the higher education setting. A comprehensive study of related literature with requirements elicited from the target population in a selected premier university in Malaysia through document analysis, interviews and survey questionnaires provided the foundation for the system development. By adopting the balanced scorecard, the proposed system provided a means for top down alignment of organisational objectives while creating a medium of communication between the lecturers and management. Though the method suggested in this study primarily focuses on the academic staff, it addresses the lack of a representative form of performance measurement for lecturers that accommodates the complexities of the profession while providing the potential adoption of an unconventional method to encourage excellence and development amongst all levels of employees in the industry.     

New approaches to positive observer design for discrete-time positive linear systems

This paper aims at providing new design approaches for positive observers of discrete-time positive linear systems based on a construction method of linear copositive Lyapunov function for positive systems. First, an efficient positive observer design approach is proposed by using linear programming such that the observer error system is exponentially stable. Furthermore, an interval observer design is proposed for uncertain positive systems. Then, the results are extended to positive time delay systems. In contrast with the previous design approaches, the new design method provides a general observer design with lower computational burden. Finally, three comparison examples are given to show the merit of the new design approach.     

The impact of the pandemic on early career researchers' work-life and scholarly communications: A quantitative aerial analysis

After two-years of repeat interviewing early career sciences/social sciences researchers from around the world about their work life and scholarly communications in pandemic-times, the Harbingers-2 project is in a position to release quantitative data on the pandemic's overall impact. The data comes from around 50 questions asked in the third and final round of interviews with 147 early career researchers (ECRs), which had a codifiable element to them (such as yes, no, do not know). The 19 scholarly topics covered include: pandemic-related research; research funding; changes to the workplace/working from home; pandemic-incurred stress and anxiety; teaching; employment security; career progression; mentoring; assessment (including metrics); collaboration; searching/finding information; ethics; networking; informal communication; publishing; sharing; pre-prints; outreach; and scholarly transformations. The main findings are that in six broad aspects of ECRs' work-life and scholarly behaviour, more than 50% of ECRs were impacted by the pandemic, with remote teaching having the greatest impact. By way of comparison, in another six aspects there was little change, least of all when it came to sharing activities. Among the countries studied, Malaysia stood out as being the most impacted, and of the disciplines it was the medical sciences and the soft social sciences most impacted.     

Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide

Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion formation.Piper sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell injury.Thus,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVECs).In this experiment,HUVECs were obtained by collagenase perfusion of the large vein in the umbilical cord and cultured in medium M200 supplemented with low serum growth supplementation(LSGS).HUVECs were treated with various concentrations of H2O2(0-1000 μmol/L) and it was observed that 180 μmol/L H2O2 reduced cell viability by 50% as denoted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay.Using the above concentration as the positive control,the H2O2-induced HUVECs were concomitantly treated with various concentrations(100,150,250 and 300 μg/ml) of three different extracts(aqueous,methanol and hexane) of PS.Malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX) levels showed a significant increase(P0.05) in HUVECs compared to the negative control.However,PS extracts showed a protective effect on HUVECs from H2O2-induced cell apoptosis with a significant reduction in MDA,SOD,CAT and GPX levels(P0.05).Furthermore,PS had exhibited ferric reducing antioxidant power with its high phenolic content.Hence,it was concluded that PS plays a beneficial role in reducing oxidative stress in H2O2-induced HUVECs.     

Common European framework of reference for languages (CEFR): insights into global policy borrowing in Malaysian higher education

The Common European Framework of Reference for Languages (CEFR) has emerged as a global policy in language education which has been ‘borrowed’ by nations across the world. This paper presents a critical analysis of Malaysia’s borrowing of the CEFR as part of English language curriculum reform with particular reference to policy motivation and implementation processes as outlined in the English Language Education Roadmap for Malaysia (2015–2025). The analysis draws on Phillips and Ochs’s (2003, “Processes of Policy Borrowing in Education: Some Explanatory and Analytical Devices.” Comparative Education 39 (4): 451–461.) framework for examining educational policy borrowing to highlight challenges as well as prospects of the implementation of the global policy in higher education in Malaysia.     

Optimal trajectory tracking solution: Fractional order viewpoint

In this paper, a generalized trajectory tracking problem for a closed-loop control system is formulated in the optimal control context. A linear time varying plant is considered to track a closed-loop desired trajectory generated by a given mechanism. The theoretical results are obtained based on the Hamilton-Jacobi-Bellman theory in which some generalized semiquadratic value functions are employed as the Lagrangian. In addition, we employ a non-integer order integral of Riemann-Liouville type as the cost functional, so that the trajectory tracking process can be evaluated in an extended optimum manner wherein the fractionality plays the main role. By selecting a suitable fractional order of the integral, a satisfactory optimal control system can be deduced in which least concentration on selecting the weighting matrices is needed. To show the effectiveness of the results, some numerical examples illustrate the potentials.     

Finite-time stability analysis and stabilization for linear discrete-time system with time-varying delay

The problem of finite-time stability for linear discrete-time systems with time-varying delay is studied in this paper. In order to deal with the time delay, the original system is firstly transformed into two interconnected subsystems. By constructing a delay-dependent Lyapunov–Krasovskii functional and using a two-term approximation of the time-varying delay, sufficient conditions of finite-time stability are derived and expressed in terms of linear matrix inequalities (LMIs). The derived stability conditions can be applied into analyzing the finite-time stability and deriving the maximally tolerable delay. Compared with the existing results on finite-time stability, the derived stability conditions are less conservative. In addition, for the stabilization problem, we design the state-feedback controller. Finally, numerical examples are used to illustrate the effectiveness of the proposed method.     

Anti-disturbance control based on disturbance observer for nonlinear systems with bounded disturbances

A composite anti-disturbance control problem for a class of nonlinear systems is studied in this paper. There are two types of disturbances in the systems, one is the matched disturbance with bounded variation rate, the other is the unmatched time-varying disturbances. A nonlinear disturbance observer is designed to estimate the matched disturbances, which can be presented separately from the controller design. By integrating DOBC with back-stepping method, a composite DOBC and back-stepping controller is proposed, and the disturbance estimations are introduced into the design of virtual control laws to compensate the unmatched disturbances. In addition, it is proved that all the states in the closed-loop system are uniformly ultimate bounded (UUB). Finally, a numerical example is given to demonstrate the feasibility and effectiveness of the proposed method.