学生"创业园"对高职教育的辅助价值

本文就学生"创业园"的创建理念,运用准社会化运作管理调适高职生的思维方式、心理状态和日常行为,实现其在高职教育中的辅助价值进行了阐述.     

我国农业生态环境的修复和保护

农村生态环境保护直接关系到农业的可持续发展与国民经济的发展.本文分析了当今农业生态系统中存在的问题,并提出了农村生态环境管理的具体防治措施及搞好农业生态的几点建议.     

移动增值服务创新激励分析

在移动增值服务的提供过程中,服务产品的创新是推动市场发展的核心动力。本文通过建立一个简单的模型,分析运营商如何运用定价和监管策略,来最大限度促进创新并增加系统的整体效用。分析表明,SP在创新方面的投入受到监管水平、运营商的收费策略以及市场风险程度的影响。最优的收费策略能够充分考虑在激励不足的损失与提供保险收益之间进行平衡(trade off)。最优的监管投入则随着创新能力的提高而提高。     

高校品牌创新之我见

面对日益激烈的品牌战争,我国各高校也应该充分地意识到品牌对一所高校生死存亡的重要意义。高校要积极采取品牌创新的各种策略,努力使我国高校发展成不仅在国内有名、而且在国外也有一定知名度的品牌高校。     

美国国家实验室科研特征的情报计量学分析

选取美国能源部、航空航天局(NASA)、国防部下属19家国家实验室,从论文总量、资助机构、作者来源、国内外合作研究、科学设施与装置的利用情况及论文影响力几个方面分析美国典型国家实验室的科研特征.研究发现,美国典型国家实验室的科研活动以政府主管部门为其主要资助机构,国防相关部门为重要资助来源,以灵活多样的人才聘用形式(双...     

科技社团在科技强国建设中的作用

通过回顾近代以来典型科技强国的发展经验及与科技社团的关系,表明以科技社团为核心的科技类社会组织在一个国家的科技进步中扮演着重要角色、发挥着重要作用,同时科技社团的发展也是反映科技强国建设的一个重要指标.最后,提出我国在建设科技强国发展进程中大力加强科技社团建设的建议.     

Sequence- and structure-selective mRNA m5C methylation by NSUN6 in animals

mRNA m⁵C, which has recently been implicated in the regulation of mRNA mobility, metabolism and translation, plays important regulatory roles in various biological events. Two types of m⁵C sites are found in mRNAs. Type I m⁵C sites, which contain a downstream G-rich triplet motif and are computationally predicted to be located at the 5^′ end of putative hairpin structures, are methylated by NSUN2. Type II m⁵C sites contain a downstream UCCA motif and are computationally predicted to be located in the loops of putative hairpin structures. However, their biogenesis remains unknown. Here we identified NSUN6, a methyltransferase that is known to methylate C72 of tRNA^Thr and tRNA^Cys, as an mRNA methyltransferase that targets Type II m⁵C sites. Combining the RNA secondary structure prediction, miCLIP, and results from a high-throughput mutagenesis analysis, we determined the RNA sequence and structural features governing the specificity of NSUN6-mediated mRNA methylation. Integrating these features into an NSUN6-RNA structural model, we identified an NSUN6 variant that largely loses tRNA methylation but retains mRNA methylation ability. Finally, we revealed a weak negative correlation between m⁵C methylation and translation efficiency. Our findings uncover that mRNA m⁵C is tightly controlled by an elaborate two-enzyme system, and the protein-RNA structure analysis strategy established may be applied to other RNA modification writers to distinguish the functions of different RNA substrates of a writer protein.     

征收电子商务税的必要性分析以及相应对策探究

高度普及的网络生活,促进了电子商务的快速发展。在此背景下,一方面,传统的门店商务受到前所未有的冲击;另一方面,我国的传统税收体制也受到前所未有的挑战。也正因为如此,我国正面对着"电商征税,该不该""电商征税,难不难""电商征税,谁受益"等问题。将主要分析征收电子商务税的必要性以及征收电子商务税所带来的冲击,由此探究如何合理征税、增加财政收入、创造公平竞争平台和网络环境、提升就业率等,并提出相应的解决对策。     

我国图书情报领域期刊论文的科学数据引用特征研究

[目的/意义] 探索期刊论文科学数据引用特征与规律不仅有助于描述学科领域对科学数据的利用情况，还能够揭示学术成果表达中的数据引用模式。[方法/过程] 以我国图书情报领域6种期刊2017年与2018年第一期刊载论文为样本，结合国家标准《信息技术科学数据引用》的引用元素，采用内容分析法从9个维度对样本论文的科学数据引用行为进行数据编码，应用统计学方法描述图书情报领域期刊论文科学数据引用特征并探索不同维度特征间的关联关系。[结果/结论] 图书情报领域期刊论文广泛引用来自国内外的统计整理类科学数据，对期刊论文中个人研究科学数据的引用量较大；科学数据引用标注方式与科学数据类型存在一定对应关系，但多样化的标注方式缺乏统一性；二手引用现象较为突出，二手引用程度与科学数据创建者类型相关。     

Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

According to the statistics of the World Health Organization, an estimated 17.9 million people die from cardiovascular diseases each year, representing 31% of all global deaths. Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases. However, it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression. Here, we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP. We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts, and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices. We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for >1500 min in total on 44 subjects in an intensive care unit. The maximum absolute errors of diastolic and systolic blood pressure were ±7/±10 mm Hg, respectively, in immobilized, and ±10/±14 mm Hg, respectively, in walking scenarios. These strategies provide advanced blood pressure monitoring techniques, which would directly address an unmet clinical need or daily use for a highly vulnerable population.