Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis

Objectives:Severe acute pancreatitis(SAP) can lead to acute lung injury(ALI) .The purpose of this paper is to investigate the protective effect of clodronate-containing liposomes on ALI in rats with SAP.Methods:The thin film method was used to prepare liposomes.Sprague-Dawley rats were randomly divided into three groups.After the SAP model was established by injecting 5%(w/v) sodium taurocholate(2 ml/kg body weight) into the subcapsular space of the pancreata,normal saline was administered to the control(C) group,phosphate buffer solution(PBS) -containing liposome to the Pgroup,and clodronate-containing liposome to the Tgroup through tail veins.Blood samples were obtained from the superior mesenteric vein at 2 and 6 h to measure the levels of amylase,interleukin-6(IL-6) ,and tumor necrosis factor-α(TNF-α) .Morphological changes in the pancreata and lung were observed using hematoxylin and eosin(HE) staining,while cell apoptosis was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) .In addition,the macrophage marker cluster of differentiation 68(CD68) in lung tissue was detected with immunohistochemistry.Results:Blood levels of amylase,IL-6,and TNF-αwere significantly increased in the Pgroup compared to those in the Tgroup(P0.05) .In the Tgroup,large numbers of TUNEL-positive cells were observed,but no or few in the C and Pgroups.Gross inspection and HE staining of pancreata and lung showed dramatic tissue damage,including inflammation and necrosis in the Pgroup.Less remarkable changes were noted in the Tgroup,and the C group exhibited normal histology.The histological scores according to Kaiser's criteria were consistent with HE findings.The number of CD68-positive macrophages decreased in the Tgroup.Conclusions:Clodronate-containing liposomes have a protective effect against ALI in rats with SAP.Blockade of macrophages may represent a novel therapeutic strategy in SAP.     

从《红字》看霍桑的清教主义观和人文主义思想观

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将家教纳入教育实习规划的管理模式探析

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Dynamics of a prestressed Timoshenko beam subject to arbitrary external load

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大学生恋情对幸福感的影响研究

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对符二诗歌的浅析

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谈钱基博《现代中国文学史》的书写方式

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大学英语“情景模拟”教学法探析

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对"淡化意识形态"思潮的思考

当前,我国思想政治工作面临一个严峻问题,就是理论界和社会上出现了一种"淡化意识形态"思潮,其基本主张可以概括为"告别革命,远离政治,疏离主题,淡化意识形态".这一思潮有着深刻的思想背景,成为影响思想政治工作的巨大障碍.应对这种错误思潮,必须坚持以马克思主义为指导,坚决反对指导思想的多元化;努力建设好社会主义核心价值体系;紧紧抓住发展这个"第一要义".     

后现代主义视野下的成人教育观

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