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141.
Yogita S. Raut Uma S. Bhartiya Purushottam Kand Rohini W. Hawaldar Ramesh V. Asopa Lebana J. Joseph MGR Rajan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):99-103
The aim was to study the genotoxic effect of high concentration of thyroxine (T4) in vivo in peripheral blood lymphocytes (PBL) of the patients suffering from thyroid disorders. The effect was compared by performing in vitro experiments with addition of increasing concentration of T4 (0.125–1 µM) in whole blood samples from healthy donors. Cytokinesis-blocked micronuclei (CBMN) assay method was used to assess the DNA damage in the PBL. The study included 104 patients which were grouped as control (n = 49), hyperthyroid (n = 31) and hypothyroid (n = 24). A significant increase in micronuclei (MN) frequency was observed in hyperthyroid patients when compared with the hypothyroid and euthyroid group thereby suggesting increased genotoxicity in hyperthyroidism (p < 0.001). A significant increase in MN frequency was observed at T4 concentration of 0.5 µM and above when compared to lower T4 concentrations (0.125 and 0.25 µM) and basal in in vitro experiments (p = 0.000). The results indicate that the T4 in normal concentration does not exhibit the genotoxic effect, as observed in both the in vivo and in vitro experiments. The toxicity of T4 increases at and above 0.5 μM concentration in vitro. Therefore acute T4 overdose should be handled promptly and effectively so as to avoid the possible genotoxic effect of high concentration of T4 in vivo. 相似文献
142.
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144.
Joseph G. Eisenhauer 《Teaching Statistics》2011,33(2):38-42
This note shows how some density functions for continuous probability distributions can be constructed in a transparent manner to help students appreciate their development. 相似文献
145.
The US Natality files provide information on medical procedures and health related behavior during pregnancy and childbirth. The data set represents nearly the universe of mothers who give birth in the US, providing the most complete coverage possible of medical care and health behavior among a specific patient population. We document gaps in outcomes by education of the mother and the changes in these educational gaps during 1989-2002. 相似文献
146.
Are You Satisfied? PhD Education and Faculty Taste for Prestige: Limits of the Prestige Value System
Emory Morrison Elizabeth Rudd Joseph Picciano Maresi Nerad 《Research in higher education》2011,52(1):24-46
This paper empirically evaluates Caplow and McGee??s (The academic marketplace, 1958) model of academia as a prestige value system (PVS) by testing several hypotheses about the relationship between prestige of faculty appointment and job satisfaction. Using logistic regression models to predict satisfaction with several job domains in a sample of more than 1,000 recent social science PhD graduates who hold tenure-track or tenured faculty positions, we find that the relationship between prestige of faculty appointment and job satisfaction is modified by PhD program prestige. Graduates of high prestige PhD programs value prestige more highly and graduates of low prestige programs value salary more highly. We explain our findings by incorporating reference group theory and a theory of taste formation into our model of the academic PVS, which identifies PhD programs as sites of socialization to different tastes for prestige (a process of cultural transmission) in addition to their well recognized role in transmission of human and social capital. We discuss practical and theoretical implications of our findings in relation to efforts to measure PhD program quality and to understand the structure of academic labor markets. 相似文献
147.
The purpose of this study was to explore the nature of requisite teacher knowledge for teaching lower-track science students.
Using video accounts, student focus groups, and teacher reflections researchers documented missteps, dead-ends, and unfruitful
trajectories informed by the teacher’s incoming knowledge and compared these instances to necessary modifications informed
by students’ voices and cultural artifacts. Our study revealed the shifting nature of sociocultural and pedagogical content
knowledge of the teacher immersed in a context unlike that he experienced as a student. Results showed that teachers of majority
backgrounds could learn to teach diverse students with at least moderate success from the perspective of their students. Implications
for research and teacher education in diverse settings are discussed. 相似文献
148.
Joseph J. Esposito 《Publishing Research Quarterly》2011,27(1):13-18
The migration from print books to ebooks is more than a change of format; it is also the first step in an ongoing process,
whose final outcome is hard to predict. Ebooks are likely to lead to a restructuring of the industry by enabling cross-border
commerce. This in turn is likely to lead to difficult disputes over territorial rights. It appears probable that these disputes
will be resolved by an assertion of the dominance of the American market and the publishers that already serve it well, as
authors are likely to place their rights with practitioners in the largest markets. This in turn will lead to the acquisition
of many smaller “national” publishers, which cannot compete on a world stage with truly global publishers. But rather than
simply becoming sources of editorial product for American-based global marketing machines, smaller publishers operating in
different regions will respond through innovation, both in product design (attempting to do electronically what cannot be
done in print) and in developing new marketing plans that the giant publishers would be indisposed to pursue. 相似文献
149.
Epshteyn AA Maher S Taylor AJ Holton AB Borenstein JT Cuiffi JD 《Biomicrofluidics》2011,5(4):46501-465016
The design and fabrication of a membrane-integrated microfluidic cell culture device (five layers,≤500 μm total thickness) developed for high resolution microscopy is reported here. The multi-layer device was constructed to enable membrane separated cell culture for tissue mimetic in vitro model applications and pharmacodynamic evaluation studies. The microdevice was developed via a unique combination of low profile fluidic interconnect design, substrate transfer methodology, and wet silane bonding. To demonstrate the unique high resolution imaging capability of this device, we used oil immersion microscopy to image stained nuclei and mitochondria in primary hepatocytes adhered to the incorporated membrane 相似文献
150.
Zaid Al-Shammari Ph.D Joseph Mintz Ph.D 《Journal of Research in Special Educational Needs》2022,22(2):105-115
This paper presents a study which has evaluated the extent to which a sample of elementary special education teachers in Kuwait understand and make use of evidence-informed approaches in the mainstream classroom with children with special educational needs. A questionnaire survey was developed and administered (N = 150), focussing on teacher understanding of and use of two selected evidence-informed approaches: peer tutoring strategy and the JIGSAW strategy. Results revealed a good degree of understand and use of both strategies. Recommendations are made in relation to further research on the evidence-informed practice for the effective inclusion of children with special educational needs in Kuwait and internationally. 相似文献