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211.
Different term weighting techniques such as $TF\cdot IDF$ or BM25 have been used intensely for manifold text-based information retrieval tasks. Their use for modeling term profiles for named entities and subsequent calculation of similarities between these named entities have been studied to a much smaller extent. The recent trend of microblogging made available massive amounts of information about almost every topic around the world. Therefore, microblogs represent a valuable source for text-based named entity modeling. In this paper, we present a systematic and comprehensive evaluation of different term weighting measures, normalization techniques, query schemes, index term sets, and similarity functions for the task of inferring similarities between named entities, based on data extracted from microblog posts. We analyze several thousand combinations of choices for the above mentioned dimensions, which influence the similarity calculation process, and we investigate in which way they impact the quality of the similarity estimates. Evaluation is performed using three real-world data sets: two collections of microblogs related to music artists and one related to movies. For the music collections, we present results of genre classification experiments using as benchmark genre information from allmusic.com . For the movie collection, we present results of multi-class classification experiments using as benchmark categories from IMDb . We show that microblogs can indeed be exploited to model named entity similarity with remarkable accuracy, provided the correct settings for the analyzed aspects are used. We further compare the results to those obtained when using Web pages as data source.  相似文献   
212.
Determination of amyloid β (Aβ) isoforms and in particular the proportion of the Aβ 1-42 isoform in cerebrospinal fluid (CSF) of patients suspected of Alzheimer’s disease might help in early diagnosis and treatment of that illness. Due to the low concentration of Aβ peptides in biological fluids, a preconcentration step prior to the detection step is often necessary. This study utilized on-chip immunoprecipitation, known as micro-immunoprecipitation (μIP). The technique uses an immunosorbent (IS) consisting of magnetic beads coated with specific anti-Aβ antibodies organized into an affinity microcolumn by a magnetic field. Our goal was to thoroughly describe the critical steps in developing the IS, such as selecting the proper beads and anti-Aβ antibodies, as well as optimizing the immobilization technique and μIP protocol. The latter includes selecting optimal elution conditions. Furthermore, we demonstrate the efficiency of anti-Aβ IS for μIP and specific capture of 5 Aβ peptides under optimized conditions using various subsequent analytical methods, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), capillary electrophoresis, microchip electrophoresis, and immunoblotting. Synthetic Aβ peptides samples prepared in buffer and spiked in human CSF were analyzed. Finally, on-chip immunoprecipitation of Aβ peptides in human CSF sample was performed.  相似文献   
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The present study investigated whether the marked sex difference in the original mental rotation test (MRT) is simply a result of sex differences in response strategies. Thirty-four participants (17 males, 17 females) completed the revised Vandenberg and Kuse MRT [Peters, M., Laeng, B., Latham, K., Jackson, M., Zaiyouna, R., & Richardson, C. (1995). A redrawn Vandenberg & Kuse Mental Rotations Tests: Different versions and factors that affect performance. Brain and Cognition, 28, 39–58.] and a modified MRT. In the modified version, the number of matching figures varied from zero to four, so that participants had to match every single figure to the target, impeding leaps. Both men and women showed reduced performance in the modified version. However, men were clearly more affected than women. Although sex differences in the modified MRT were somewhat reduced, men still outperformed women (original MRT: d = .95, modified MRT: d = .76). The findings suggest that men rely more on a leaping response strategy than women, however, the robust sex differences in MRT was only marginally affected by sex differences in response strategies.  相似文献   
216.
Studies on the interface between cognitive ability (intelligence) and personality in the prediction of academic performance have yielded mixed results so far. Especially an interaction between conscientiousness (and its facet achievement striving) and intelligence has been investigated. The hypothesis is that conscientiousness enhances the impact of intelligence on performance. Based on findings supporting the idea of a non-linear relationship between conscientiousness and performance the present study aimed at a clarification of the mixed results. Given such a non-linear relationship, studies investigating a possible moderating effect should pay attention to the performance level. A sample of N = 271 students completed a conscientiousness and an intelligence measure. Moderated regression analyses revealed a moderation for conscientiousness but not its facet achievement striving in the total sample. However, splitting the sample into a low and a high performer group revealed an enhancing effect of achievement striving for low performers and a buffering effect for high performer. Practical as well as theoretical implications are discussed.  相似文献   
217.
The aim of this study is to investigate the influence of family environment, school grade, performance and social behavior of students on educational trajectory. The research project Family-School-Job (FASE B) utilized a representative longitudinal sample of 454 students and their primary reference persons in the canton of Bern (Switzerland). Using step-wise logistic regression analyses, the study investigated the predictive value of family-based and individual determinants at the end of primary school for the transition to lower secondary schooling and for the development at upper secondary education (academic education or vocational training). The transition to lower secondary education was more strongly influenced by grades than by results of standardized performance tests. Parental expectation, parents’ socio-economic background and by classroom misbehavior were also important predictors.Parental expectations predicted educational pathways into secondary education whereas grades in German andgender were partially significant only. Parental expectations permit precise predictions of educational pathways, even when controlling for students’ grades and performance.  相似文献   
218.
The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and evaluate such policies. The contribution of this paper is to translate and concretize the challenges of system innovation policy towards scope for policy action and analysis. Building on insights from transition studies we group the challenges into four domains: directionality, experimentation, demand articulation, and policy coordination and learning. We relate challenges within the four domains to three generic features of innovation systems: interests and capabilities of actors, networks, and institutions. The derived framework is applied in a case study on the strategic innovation programmes, a recent policy initiative by Vinnova, Sweden’s Innovation Agency, targeting system innovation.  相似文献   
219.
Knowledge base combinations and firm growth   总被引:1,自引:0,他引:1  
The link between knowledge and firm growth has been a core topic in economics of innovation for a long time. However, despite strong theoretical arguments, empirical evidence remains inconclusive. One important reason for this conundrum may be the failure of standard indicators to capture firm innovation activities comprehensively. We contribute to overcoming this limitation by looking in the knowledge processes that drive variegated forms of innovation and aim thereby to establish a solid relationship with firm growth in more detail. Our arguments draw on the differentiated knowledge base approach, distinguishing between analytical, synthetic, and symbolic knowledge. We measure the three types of knowledge bases with detailed longitudinal linked-employer-employee micro-data from Sweden. Econometric findings based on a very large sample of small and medium-sized firms indicate significantly positive effects of the three knowledge types, and in particular combinations thereof, on firm growth. In addition, we show that not only high-growth but also slow-growth firms benefit immensely from the use of combinatory knowledge bases. We find evidence on a curvilinear relation between knowledge bases and growth of firms. Beyond certain thresholds increasing the knowledge bases further results in decreasing firm growth. Our results remain robust in a wide range of specifications and econometric models.  相似文献   
220.
Dieser Beitrag hat die organisatorischen Veränderungen an Österreichs Universitäten während der letzten 40 Jahre zum Gegenstand. Der Weg von der Ordinarienuniversität zur unternehmerischen Universität wird nachgezeichnet und die Chancen und Risiken einer Vermarktlichung der Koordinationsmechanismen an der Universität werden diskutiert. Probleme werden insbesondere bei der Messung und Steuerung wissenschaftlicher Leistung geortet. Als besonderes Risiko der unternehmerischen Universität wird die Verdrängung innerer Motivation durch äußere Motivation im Handeln von WissenschafterInnen gesehen.  相似文献   
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