Effect of oral antioxidant supplementation on lipid peroxidation during radiotherapy in head and neck malignancies

The objectives of the present study were to ascertain the variations in the serum levels of malondialdehyde and total antioxidant status, in head and neck malignancies with different stages, with and without oral antioxidant supplementation, before and after radiotherapy, and to validate the protective effects of an antioxidant supplementation during radiotherapy. The pretreatment values of serum malondialdehyde were significantly raised, while that of serum total antioxidant status were significantly declined in all the stages of head and neck malignancies, when compared with the healthy controls values (P<0.001). A significant correlation was observed related to the studied parameters and different stages of the disease. The study suggests that an oral antioxidant supplementation during radiotherapy is an effective mode in reducing oxidative stress. Antioxidant supplementation during radiotherapy may serve as an adjuvant therapy in malignancies offering a protection to normal cells that may further reduce the risk of developing secondary cancers.     

Clinical Significance of Ischemia Modified Albumin in Critically Ill Patients with Sepsis

The study was conducted on 38 patients admitted into the intensive care unit with a provisional diagnosis of sepsis and 25 apparently healthy volunteers as controls. Serum procalcitonin (PCT) was assayed by an electrochemiluminescence method. Serum ischemia modified albumin (IMA), expressed as absorbance units was assayed by the albumin cobalt binding test. Patients with sepsis had significantly higher IMA levels (1.087 ± 0.786) as compared with those without sepsis (0.085 ± 0.234) with a p value <0.0001. The receiver operator characteristic (ROC) plot showed a sensitivity of 100 % and a specificity of 86.2 %. The area under the curve of the ROC plot was 0.917 with a p value of <0.0001. The higher levels of IMA serve to highlight the occurrence of ischemic damage which could be a prelude to poorer prognosis. The performance characteristics of IMA warrants its inclusion along with PCT as a parameter in the diagnosis of sepsis.     

Estimation of leg power: a two-variable model

Leg power is an essential component for success in sports and athletic performance. Therefore, the leg power measurement may help athletes, coaches, athletic trainers, and rehabilitation specialists in selecting, treating, and training athletes for a specific sport. Using a conventional 'jump and reach' test, one can accurately predict the leg power and success in anaerobic-type sports. Nineteen untrained male subjects performed 'jump and reach' vertical jumps on a force platform. Power values were calculated from the force versus time data obtained from the force platform. A regression equation was obtained to predict the power values using the weight of an individual and the 'jump and reach' height as independent variables. The regression equation is given by p = -666.3 + 14.74 [Mass (kg)] + 1925.72 [Height (m)]; [R-square = 0.69, p < 0.05].     

Hypocholesterolemic effect of water extract of the bark of banyan tree,Ficus bengalensis

The hypocholesterolemic effect of the water extract of the bark ofFicus bengalensis was investigated in 3 groups of rabbits, 5 in each group. Group 1 rabbits served as healthy controls and were fed with groundnut oil 1 ml/kg body wt. (bw) for five weeks. Groups 2 and 3 were made hypercholesterolemic by feeding orally cholesterol suspended in groundnut oil (1 ml/kg bw) at a dose of 100 mg/kg bw/day. Group 2 animals (untreated) continued to get the same amount of cholesterol for another four weeks. Group 3 animals received water extract of the bark (50 mg/kg bw/day) in addition to cholesterol as above. At the end of the 5th week, water extract not only prevented the elevation of serum cholesterol in the treated animals (Group 3) but also brought down its level to 160±14 mg% as compared to untreated animals (Group 2) 290±42 mg%. There was improvement in other parameters of lipid profile namely HDL & LDL+VLDL cholesterol and triacylglycerol.     

Raised Serum Lactate Dehydrogenase associated with gangrenous small bowel volvulus: A case report

Usually CPK, CK-MB and lactate dehydrogenase (LDH) enzymes are measured in blood during the period of myocardial infarction. The changes in LDH assay indicates duration of the infarction. The level of lactate dehydrogenase is 500 times greater in tissue than those found in serum. A small mass of damaged tissue causes leakage of enzyme and increases its level in serum. Any cause of tissue break down/hemolysis which is sufficiently severe can produce LDH pattern similar to that in myocardial infarction. We report this case of small bowel volvulus showing significant increase in LDH. It may be due to tissue necrosis which increases the level of LDH in serum.     

Urban Pre-service K-6 Teachers’ Conceptions of Citizenship and Civic Education: Weighing the Risks and Rewards

To effectively help urban pre-service teachers to provide civic education opportunities in their future classrooms, teacher educators should know how urban pre-service teachers themselves conceptualize citizenship and civic engagement. Through the research question—how do urban K-6 pre-service teachers currently enrolled in an urban education teacher certification program at a 4-year university construct key concepts and ideologies about citizenship and civic education?—we examined how 15 pre-service teachers understood these concepts. Using three conceptions of citizenship—personally responsible citizen, participatory citizen, and justice-oriented citizen (Westheimer and Kahne in Am Educ Res J 41(2):237–269, 2004)—our analysis demonstrated that urban pre-service teachers’ conceptions of their students’ lives significantly influenced their ideas about civic education in elementary schools. Although the participating pre-service teachers overwhelmingly promoted personally responsible citizenship, we found the participants to heavily weigh developmentally appropriate practice and classroom context when considering the risks and rewards of promoting justice-oriented citizenship in elementary classrooms.