全文获取类型
收费全文 | 133篇 |
免费 | 4篇 |
专业分类
教育 | 46篇 |
科学研究 | 37篇 |
各国文化 | 1篇 |
体育 | 19篇 |
文化理论 | 16篇 |
信息传播 | 18篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 14篇 |
2018年 | 9篇 |
2017年 | 10篇 |
2016年 | 9篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 17篇 |
2012年 | 8篇 |
2011年 | 10篇 |
2010年 | 4篇 |
2009年 | 6篇 |
2008年 | 5篇 |
2007年 | 2篇 |
2006年 | 2篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 2篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
排序方式: 共有137条查询结果,搜索用时 15 毫秒
1.
Gian Paolo Caviglia Luca Cabianca Sharmila Fagoonee Fabrizio M. Gili 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):114-120
Introduction
Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on the performance of first-round CRC screening programs is not known. We investigated whether fecal M2-PK alone or in combination with FIT may improve CRC screening efficacy in the general population.Materials and methods
A total of 1027 asymptomatic subjects (median age 66 [59-74] years; females 504 [49.1%]), identified through the general practitioners’ rosters, were invited for the collection of 2 fecal samples for FIT and M2-PK evaluation. Participants with at least positive one fecal test were referred for colonoscopy. Quality indicators for screening performance were calculated and analyzed using Fisher’s exact test.Results
Overall, 572 subjects underwent both FIT and M2-PK assessment (participation rate 55.7%): 93 participants showed positive results for at least one test (positivity rate 16.3%). Only 10 patients were positive for both tests. Attendance rate to colonoscopy was 86.0% and a total of 65 adenomas and 7 cancers were detected. Combined use of FIT and fecal M2-PK permitted the identification of 18 more neoplasm (25%) without improving colonoscopy workload, as deduced by the comparable number needed to scope (P = 0.402).Conclusion
The addition of M2-PK testing to FIT offers the potential to detect additional neoplasms that either do not bleed or only bleed intermittently without reducing participation rate and without increasing endoscopy workload.Key words: biomarker, colorectal cancer, occult blood, M2-type pyruvate kinase, screening 相似文献2.
Our model analyzes the effects of the interplay between environmental degradation and consumption choices on economic growth dynamics and on economic agents’ welfare. We show that if private goods can be consumed as substitutes for environmental goods, then economic growth may be fueled by environmental deterioration. In this context, undesirable economic growth may occur, characterized by an inverse correlation between aggregate capital accumulation and economic agents’ welfare. 相似文献
3.
Paolo Bardella Irene Carrasquilla García Marco Pozzo Julio Tous-Fajardo Eduardo Saez de Villareal 《Sports biomechanics / International Society of Biomechanics in Sports》2017,16(1):102-114
The purpose of this study was to analyse the raw lifting speed collected during four different resistance training exercises to assess the optimal sampling frequency. Eight physically active participants performed sets of Squat Jumps, Countermovement Jumps, Squats and Bench Presses at a maximal lifting speed. A linear encoder was used to measure the instantaneous speed at a 200 Hz sampling rate. Subsequently, the power spectrum of the signal was computed by evaluating its Discrete Fourier Transform. The sampling frequency needed to reconstruct the signals with an error of less than 0.1% was f99.9 = 11.615 ± 2.680 Hz for the exercise exhibiting the largest bandwidth, with the absolute highest individual value being 17.467 Hz. There was no difference between sets in any of the exercises. Using the closest integer sampling frequency value (25 Hz) yielded a reconstruction of the signal up to 99.975 ± 0.025% of its total in the worst case. In conclusion, a sampling rate of 25 Hz or above is more than adequate to record raw speed data and compute power during resistance training exercises, even under the most extreme circumstances during explosive exercises. Higher sampling frequencies provide no increase in the recording precision and may instead have adverse effects on the overall data quality. 相似文献
4.
Guido?Candela Paolo?Figini Antonello?E.?ScorcuEmail author 《Journal of Cultural Economics》2004,28(4):285-302
This paper proposes a price index for artists adjusted for the quality of the paintings, based on the ratio between the average market price and the average pre-sale estimate for paintings. We apply this methodology to a group of selected artists and schools presented in auctions worldwide in the period 1990–2001. A comparison with quality unadjusted and hedonic indices is also conducted.JEL Classification: C10, Z11 相似文献
5.
6.
John Colvin Chris Blackmore Sam Chimbuya Kevin Collins Mark Dent John Goss Ray Ison Pier Paolo Roggero Giovanna Seddaiu 《Research Policy》2014
Processes of designing for systemic innovation for sustainable development (SD) through the lens of three long-term case studies are reported. All case studies, which originated from the SLIM (Social Learning for the Integrated Management and Sustainable Use of Water at Catchment Scale) Project, funded within the EU Fifth Framework Program (2001–2004), constitute inquiry pathways that are explored using a critical incident approach. The initial starting conditions for each inquiry pathway are compared; significant pathway dependencies are identified which foster the development of social learning processes locally, but constrain their uptake and embedding across the wider system of interest. In the first case study, in England & Wales, promising developments in the application of social learning approaches to river basin planning over an initial 3-year period were subsequently marginalised, only to resurface towards the end of the 10-year period of study. In the second, South African case study, significant spaces for social learning and innovation in integrated water resources management were opened up over a five year period but closed down again, primarily as the result of lack of policy support by national government. The third, Italian, case study was designed to assess options for adapting to climate change by opening up new learning spaces between researchers, stakeholders and policy makers. A case for investing in local level systemic innovation through social-learning praxis design approaches and in learning processes around well contextualised case-studies is supported. However, concomitant investment by policy makers in social learning as an alternative, but complementary, governance mechanism for systemic innovation for SD is needed. 相似文献
7.
Hypercomputation and the Physical Church-Turing Thesis 总被引:1,自引:0,他引:1
8.
Fabio Lucidi Arnaldo Zelli Luca Mallia Caterina Grano Paolo M. Russo Cristiano Violani 《Journal of sports sciences》2013,31(5):447-456
Abstract In this study, we assessed the longitudinal effects of social-cognitive mechanisms on the self-reported use of doping substances and supplements among Italian high school students. In total, 1232 students completed questionnaires measuring various psychological factors hypothesized to influence students' intention to use substances. Three months later, 762 of the students completed the same questionnaires a second time and also reported their use of substances during the time between assessments. Overall, the percentages of students using doping substances (2.1%) or supplements (14.4%) were consistent with values reported in the literature. Analysis of the data showed that adolescents' intention to use doping substances increased with stronger attitudes about doping, stronger beliefs that significant others would approve of their use, a stronger conviction that doping use can be justified, and a lowered capacity to resist situational pressure or personal desires. In turn, stronger intentions and moral disengagement contributed to a greater use of doping substances during the previous 3 months. Doping use was also correlated significantly to supplementation. In conclusion, our results provide novel information about some of the psychological processes possibly regulating adolescents' use of doping substances and supplements. The results also highlight possible areas for future study and intervention, focusing on the prevention of adolescents' substance use. 相似文献
9.
Maintaining the microclimatic parameters at the desired value is essential for artefacts preservation. In order to control the status of the microclimatic parameters, a continuous monitoring of the indoor environmental provides conservators, curators, restorers, and lenders with an exact knowledge of the microclimatic conditions under which the works of art are kept. Moreover, the monitoring results give important information in order to make adequate changes to the control strategy of microclimatic parameters. From this point of view, monitoring is an essential tool to develop an actual preventive control programme aimed at maintaining the optimal microclimatic conditions for preservation. As a consequence, long-term monitoring has to be applied to prevent deterioration of works of art. The widespread opinion that a correct approach to the topic of microclimate control for artefacts preservation is not only and necessarily to provide buildings with sophisticated environmental control systems, but mainly to investigate the actual environmental dynamics and, before any structural intervention, to define the compatibility between the climate control potentials and the preservation requirements, has become more and more firm among the experts. Monitoring also allows to verify the capacity of the “building and Heating, Ventilation and Air Conditioning (HVAC)” system to maintain the desired thermo-hygrometric values within the operating conditions. To this aim, the Italian Standard UNI 10829 (1999) defining monitoring, elaboration and analysis of the microclimatic data as supporting actions for artefacts preservation, led to the need of a long-term monitoring and of a statistical approach to the data management. The approach proposed by the Italian Standard has been recently adopted by a European Standard (EN 15251, 2007). In accordance with the Standards mentioned above, in this paper an operational procedure to assess the thermo-hygrometric quality in museums is firstly synthetically presented and than applied to a case study. In particular, the procedure is developed in order to define the thermo-hygrometric quality level of the exhibition areas in the large museum complex of “Santa Maria della Scala” in Siena (Italy) during the international temporary exhibition “Duccio. La nascita della pittura senese” (“Duccio. The birth of Sienese Painting”). 相似文献
10.
Bart Van Looy Paolo LandoniJulie Callaert Bruno van PottelsbergheEleftherios Sapsalis Koenraad Debackere 《Research Policy》2011,40(4):553-564
The phenomenon of entrepreneurial universities has received considerable attention over the last decades. An entrepreneurial orientation by academia might put regions and nations in an advantageous position in emerging knowledge-intensive fields of economic activity. At the same time, such entrepreneurial orientation requires reconciliation with the scientific missions of academia. Large-scale empirical research on antecedents of the entrepreneurial effectiveness of universities is scarce. This contribution examines the extent to which scientific productivity affect entrepreneurial effectiveness, taking into account the size of universities and the presence of disciplines, as well as the R&D intensity of the regional business environment (BERD). In addition, we assess the occurrence of trade-offs between different transfer mechanisms (contract research, patenting and spin off activity). The data used pertain to 105 European universities. Our findings reveal that scientific productivity is positively associated with entrepreneurial effectiveness. Trade-offs between transfer mechanisms do not reveal themselves; on the contrary, contract research and spin off activities tend to facilitate each other. Limitations and implications for future research are discussed. 相似文献