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The aims of this study were to examine the changes in plasma concentrations of inflammatory cytokines induced by training and competition in professional cyclists. We report the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), tumour necrosis factor receptors I and II (TNFR-I and -II) in a prospective, randomized, double-blind trial involving the administration of AM3 (Inmunoferon), an oral booster immunomodulator, or placebo to 16 professional cyclists (n = 8 in each group) for 65 consecutive days. Serum was collected just before treatment began (baseline), at the end of pre-competition training, before the mountain stage of the competition (60 days), 4 h after finishing this stage (62 days), and 18 h after the fifth and last day of competition (65 days). To determine the normal levels of cytokines and soluble TNF receptors, individual samples from 14 moderately trained healthy controls were studied. After 60 days of training, the serum concentrations of IL-6 did not differ significantly from those at the beginning of the study for either group of cyclists (placebo and AM3). A significant rise was seen in IL-6 concentrations in both the AM3 and placebo groups at 62 days, 4 h after finishing the mountain stage. The increase was significantly greater in the placebo group than in the AM3 group. At 65 days of treatment, 18 h after the fifth and last day of competition, IL-6 concentrations were similar to those recorded at the end of the training, but were significantly higher in the placebo group than in the AM3 group. At the end of training, serum TNFR-I concentrations in both groups of cyclists were significantly lower than at baseline. The concentrations of serum TNFR-I and -II both 4 h after finishing the mountain stage and 18 h after the fifth and last day of competition were significantly higher than those recorded after training in both groups. Professional cycling competition is associated with increases in serum IL-6 and TNFR-I and -II concentrations. Inmunoferon treatment reduced significantly the concentrations of IL-6 but not those of TNFR-I and -II. 相似文献
74.
The aims of this study were to investigate the energy build-up and dissipation mechanisms associated with using an arm swing in submaximal and maximal vertical jumping and to establish the energy benefit of this arm swing. Twenty adult males were asked to perform a series of submaximal and maximal vertical jumps while using an arm swing. Force, motion and electromyographic data were recorded during each performance and used to compute a range of kinematic and kinetic variables, including ankle, knee, hip, shoulder and elbow joint powers and work done. It was found that the energy benefit of using an arm swing appears to be closely related to the maximum kinetic energy of the arms during their downswing, and increases as jump height increases. As jump height increases, energy in the arms is built up by a greater range of motion at the shoulder and greater effort of the shoulder and elbow muscles but, as jump height approaches maximum, these sources are supplemented by energy supplied by the trunk due to its earlier extension in the movement. The kinetic energy developed by the arms is used to increase their potential energy at take-off but also to store and return energy from the lower limbs and to "pull" on the rest of the body. These latter two mechanisms become more important as jump height increases with the pull being the more important of the two. We conclude that an arm swing contributes to jump performance in submaximal as well as maximal jumping but the energy generation and dissipation sources change as performance approaches maximum. 相似文献
75.
A. D. C. Peterson Brian Holmes G. De Landsheere Helena W. F. Stellwag Oskar Anweiler J. O. J. Vanden Bossche Abraham Robinson F. I. Calvert H. H. Stern J. F. Willatt Sydney Taylor M. J. Langeveld M. A. Brimer T. N. Postlethwaite Alexandre Vexliard 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1964,10(1):106-126
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Julia Mejia De Pizano 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1980,26(1):17-29
With the knowledge that malnutrition affects the quality of life of an individual, the Colombian Government set up in 1976 a unique multi-sectorial plan (PAN), to combat the country's serious malnutrition. Government agencies and private industries in the sectors of production, distribution, health, sanitation, and education have coordinated their previously independent efforts. Among the interesting aspects are the coordination of sectors through work at various levels and through control of the budget, the limitation of bureaucracy, and the decentralization of decision-making. The ongoing attempts to overcome the difficulties encountered include making decisions in the face of inconclusive knowledge on what constitutes a well-balanced diet; combating the lack of knowledge of professionals about the environment of the poorest percentage of the population; and revising the traditional teaching method to make it more successful through a multi-media approach to assure wider coverage and more impact for the least cost, using materials such as games, puppets, posters and radio.
Zusammenfassung In der Erkenntnis, dass Untererernährung die Lebensqualität des Menschen beeinträchtigt, erstellte die kolumbianische Regierung im Jahre 1976 einen einzigartigen, mehrere Sektoren umfassenden Plan (Pan), um die schwerwiegende Unterernährung im Lande zu bekämpfen. Gemäss diesem Plan werden jetzt die früher zerstreuten Bemühungen von Behörden und privaten Industrieunternehmen auf den Sektoren Produktion, Verteilung, Gesundheit, Kanalisation und Erziehung koordiniert. Zu den interessantesten Aspekten gehören die Koordinierung von Sektoren durch Arbeit auf verschiedenen Ebenen sowie durch Kontrolle der Etats, die Beschränkung der Bürokratie und die Dezentralisierung von Entscheidungsbefugnissen. Unter den Versuchen, die bestehenden Schwierigkeiten zu überwinden, werden hervorgehoben: Entscheidungen angesichts unzureichenden Verständnisses von ausgewogener Ernährung; Bekämpfung des Mangels an Kenntnissen von Umweltspezialisten über den ärmsten Teil der Bevölkerung; und Revision der traditionellen Lehrmethoden mit dem Ziel, sie durch Einführung eines Multi-Medienansatzes, d.h. durch den Gebrauch von Spielen, Marionetten, Plakaten und Radio erfolgreicher zu gestalten.
Résumé Conscient du fait que la sous-alimentation affecte la qualité de vie d'un individu, le Gouvernement colombien a appliqué en 1976 un plan unique à secteurs multiples (PAN) dont le but est de combattre la sérieuse sousalimentation du pays. Les agences gouvernementales et les industries privées appartenant aux secteurs de la production, de la distribution, de la santé, de l'hygiène et de l'éducation coordonnent désormais leurs efforts précédemment dispersés. Parmi les aspects intéressants de ce plan, on relève la coordination des secteurs tant au moyen du travail à différents niveaux que du contrôle du budget, la limitation de la bureaucratie et la décentralisation de la prise de décision. Les efforts qui se poursuivent dans l'intention de venir à bout des difficultés rencontrées visent à prendre des décisions malgré les connaissances nonconcluantes de ce qui constitue un régime bien équilibré; à combattre le manque de connaissance des professionnels sur l'environnement du pourcentage le plus pauvre de la population; à réviser la méthode d'enseignement traditionnel en utilisant des moyens d'approche par multimedia, ceci afin d'assurer une plus grande couverture de la population, avec un impact supérieur, et ce au moindre prix, en utilisant comme matériel des jeux, des marionnettes, des affiches illustrées ainsi que la radio.相似文献
78.
Une Équipe De L'Irem De Strasbourg 《Educational Studies in Mathematics》1974,5(4):441-459
Sans résuméRésultats d'une enquête effectuée en mai-juin 1973 par une équipe de l'IREM de Strasbourg dans les classes de 3ème du Bas-Rhin.L'équipe comprenait quatre membres de l'IREM:Mathématiciens:—Mademoiselle Anne Scherpereel—Monsieur François PluvinagePsychologues:—Mademoiselle Catherine Bloch—Monsieur Raymond Duval. 相似文献
79.
This study assessed the differential contribution of personality to the explanation of variance in achievement in the mother tongue and mathematics at the high school level. The results indicated that personality, as measured by the HSPQ, aided the explication of variance in achievement in the mother tongue significantly, but had little influence on mathematics. Personality contributed as much to the explanation of variance in the mother tongue as did the composite cognitive variable. The influence of personality on achievement in mathematics was shown to be negligible. Some practical implications for the teaching of the first language are drawn. 相似文献
80.
R. J. De Santi 《Educational gerontology》2013,39(3):271-277
The effects of writing style upon mature older readers’ reading comprehension are considered. Two narrative historical selections, the first emotive and abstract and the second nonemotive and concrete, were employed. Miscue analysis was used to evaluate the efficiency with which each reader used reading strategies across the five systems that cue meaningful comprehension. Miscues were analyzed at the word, clause, sentence, and intersentence levels. In addition, interview schedules were employed to identify readers’ perceptions of preferred reading strategies and to permit a comparison with actual performance. The findings indicate that mature older readers are consistent in cue system utilization. A preference for the word cue system influenced both the use of cues from other systems and comprehension. Use of the word‐level cue system is inversely related to the use of the other available cue systems. Preference for cues within words also appears to be inversely related to comprehending effectiveness. The subjects’ perceptions of the reading process and their actual reading performance appeared to determine patterns of cue system use more clearly than did the differences in materials. As a result, those developing materials intended for use in programs with older persons should not only be concerned with the content and quality of those materials but also the skills and perceptions of those who will use the materials. 相似文献