A "dry and wet hybrid" lithography technique for multilevel replication templates: Applications to microfluidic neuron culture and two-phase global mixing

A broad range of microfluidic applications, ranging from cell culture to protein crystallization, requires multilevel devices with different heights and feature sizes (from micrometers to millimeters). While state-of-the-art direct-writing techniques have been developed for creating complex three-dimensional shapes, replication molding from a multilevel template is still the preferred method for fast prototyping of microfluidic devices in the laboratory. Here, we report on a "dry and wet hybrid" technique to fabricate multilevel replication molds by combining SU-8 lithography with a dry film resist (Ordyl). We show that the two lithography protocols are chemically compatible with each other. Finally, we demonstrate the hybrid technique in two different microfluidic applications: (1) a neuron culture device with compartmentalization of different elements of a neuron and (2) a two-phase (gas-liquid) global micromixer for fast mixing of a small amount of a viscous liquid into a larger volume of a less viscous liquid.     

Entrepreneurialism and critical pedagogy: reinventing the higher education curriculum

This paper presents an analysis of the ways in which UK higher education (HE) has become increasingly commercialised and commodified in the post-1980s. It critiques the strategies adopted by successive UK governments to reinvigorate the relationship between educational and economic life, and to facilitate a more corporate and entrepreneurial spirit within the academy in line with the pressures of a ‘knowledge-based economy’. Arguing for a more critical exploration of teaching and learning within HE, the paper presents evidence from work carried out by the Reinvention Centre for Undergraduate Research, a Centre for Excellence in Teaching in Learning (CETL) which adopts a research-based learning approach to teaching and learning at undergraduate level.1 1. The Reinvention Centre for Undergraduate Research is a collaborative Centre for Excellence in Teaching and Learning (CETL) based between the Department of Sociology at the University of Warwick and the School for the Built Environment at Oxford Brookes University. In 2005 the Centre was awarded £500,000 recurrent over five years, and £800,000 capital funding. The recurrent funding covers staff and running costs. Capital expenditure has covered the design and development of new social teaching and learning spaces at both Warwick and Oxford Brookes. Further information on the Reinvention Centre is available at www.warwick.ac.uk/go/reinvention/. The Reinvention centre covers a range of progressive pedagogies. This article represents the specific views of the authors. Within the context of ongoing debates surrounding the relationship between teaching, learning and research in UK HE, the paper advocates a reinvention of curriculum design through an engagement with the broader principles of critical pedagogy, and in so doing, presents a critical engagement with the commercialisation of HE.     

The cognitive and academic profiles of reading and mathematics learning disabilities

The purpose of this study was to examine the cognitive and academic profiles associated with learning disability (LD) in reading comprehension, word reading, applied problems, and calculations. The goal was to assess the specificity hypothesis, in which unexpected underachievement associated with LD is represented in terms of distinctive patterns of cognitive and academic strengths and weaknesses. At the start of 3rd grade, the authors assessed 684 students on five cognitive dimensions (nonverbal problem solving, processing speed, concept formation, language, and working memory), and across Grades 3 through 5, the authors assessed performance in each academic area three to four times. Based on final intercept, the authors classified students as LD or not LD in each of the four academic areas. For each of these four LD variables, they conducted multivariate cognitive profile analysis and academic profile analysis. Results, which generally supported the specificity hypothesis, are discussed in terms of the potential connections between reading and mathematics LD.     

Prediction of maximal oxygen uptake from a 20-m shuttle run as measured directly in runners and squash players

Abstract

The aim of this study was to assess the validity of the multistage shuttle run test in predicting maximal oxygen uptake (VO ₂ max) in athletes trained in sports with different physical demands. Over a 14-day period, 10 male long-distance runners (continuous high-intensity exercise) and 10 male squash players (intermittent high-intensity exercise) performed, in random order, the multistage shuttle run test and a maximal treadmill protocol of increasing elevation which elicited VO ₂ max. Compared with direct measurement of VO ₂ max, the shuttle run test significantly underpredicted the VO ₂ max of the group of runners (n=10; P<0.01) and of the athletes as a whole (n=20; P<0.01). The correlation (r) between VO ₂ max determined by the shuttle run test and by the treadmill protocol was 0.61 (P<0.05) for the squash players, 0.71 (P<0.05) for the runners and 0.67 (P<0.01) for the athletes as a whole. As the subjects represented athletes trained specifically in sports with different physical demands, this may explain why the correlations between the shuttle run test and direct measurement of VO ₂ max are less robust than those reported in previous studies. Furthermore, our results indicate that there are sport-specific differences when predicting VO ₂ max from the multistage shuttle run test.     

The relationship between critical power and running performance

Critical power is a theoretical concept that presumes there is a certain work‐rate which may be maintained without exhaustion. The extent to which critical power predicts running performance over varying distances has not been determined, and so the aim of this study was to correlate measurements of critical power in the laboratory to running performances in the field at 40 m and 1, 10 and 21.1 km in a group of 17 male longdistance runners (mean ± s.d. age = 31.7 ± 7.3 years). Each subject ran to exhaustion on the treadmill in the laboratory at six different speeds, ranging from 17 to 25 km h^‐1. Least squares analyses were used to fit an exponential decay to the relationship between the running speed (y) versus time to exhaustion (x). Critical power was calculated as the running speed (y) coinciding with the asymptote or C parameter of the y = A‐e^(‐Bx) + C relationship. The VO₂ max was also measured in all subjects. For the data in the field, each subject was timed over 40 m and 1 km and participated in 10‐ and 21.1‐km races. The mean critical power of die subjects in this study was 18.5 ± 1.6 km h^‐1. The test‐retest correlation coefficient for the determination of critical power was r = 0.99. The mean VO₂ max, measured in a progressive exercise protocol starting at 13 km h^‐1 and increasing by 1 km h^‐1 every minute, was 59.2 ± 4.6 ml O₂ kg^‐1 min^‐1. The 40‐m times ranged from 5.57 to 6.95 s, the 1‐km times from 2:46 to 3:55 min:s, the 10‐km times from 30:43 to 42:02 min:s and the 21‐km times from 67:00 to 95:45 min:s. Critical power predicted running times over 1 km (r = ‐0.75, P< 0.001), 10 km (r = ‐ 0.85, P< 0.00001) and 21.1 km (r = ‐ 0.79, P< 0.001) in this heterogeneous group of runners. The correlation coefficients for VO₂ max and running performances were similar to the above at all distances. Even in the best relationship between critical power and the time taken to run 10 km, only 72% of the variation in the 10‐km running time could be accounted for by differences in critical power. While the test of critical power may be repeatable and correlate significantly with VO₂ max (r = 0.77, P< 0.001), the measurement lacks the degree of specificity required to predict running performance in trained subjects of varying ability.     

Insider accounts of dyslexia from research mathematicians

Educational Studies in Mathematics - Within educational research, dyslexia and other disabilities are typically conceptualized as deficits. The theory of neurodiversity encourages researchers to...     

Breaking and making curriculum from inside ‘policy storms’ in an Australian pre-service teacher education course

ABSTRACT

How teacher educators respond as policy actors from inside spaces where multiple policies and discourses collide provides insights into the ways in which policy plays out in educational contexts. By engaging and working within the uncertain space of our own contextual ‘policy storm’ we provide a narrative of enactment highlighting the roles and actions of policy actors simultaneously constrained and inspired by policy. We use the policy actor framework [Ball, S.J., Maguire, M., Braun, A., & Hoskins, K. (2011a). Policy actors: Doing policy work in schools, Discourse: Studies in the Cultural Politics of Education, 32(4), 625-639] to unpack policy meaning-making within university and faculty climates, teacher education, and curriculum reform in Health and Physical Education (HPE) in Australia. This paper has three tasks. Firstly, we set-up the conditions of uncertainty and possibility as a ‘policy storm’ and place where four disparate policies converged. Secondly, we provide an empirical and theoretical account of policy interpretation and enactment from the actors perspective. Finally, we test the policy actor framework to determine if it adequately describes our insider policy work. In moving beyond reductionist policy narratives we provide policy possibilities that illustrate enactment, are innovative, and explore the productive potential inside policy reform.     

Teaching early reading skills to non-vocal students with severe learning disabilities using Headsprout Early Reading©

Many students with learning disabilities find it difficult to acquire basic reading skills. This is even more of a challenge for students who are non-vocal. The purpose of the present study was to pilot the use of Headsprout Early Reading© (HER©), an online reading programme, with four non-vocal students with a severe learning disability (SLD), over the course of a nine-week period. Additional table-top activities were designed and implemented to augment the online instruction. None of the students completed the programme. Three students improved their early reading skills over the course of the intervention. Staff members indicated positive experiences of using HER©, especially mentioning how motivated the students were to engage with the programme. HER© for students with SLD requires one-to-one support and a longer implementation period to achieve completion; these have implications for resourcing in special schools. However, HER© shows promise with non-vocal students with learning disabilities and evidence supports the need for larger-scale evaluation research.