随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性

研究目的：二氧化钛（TiO2）纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。 创新要点：首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。 重要结论：采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。     

Public relations practices at medical journals

Many publishers of medical journals actively court coverage by the news media. However, the extent and effect of these practices are poorly understood. After reviewing prior literature regarding the impact of news coverage on the citation rate of journal articles, this paper seeks to measure the extent to which medical journals with clinical significance use public relations practices to encourage news coverage of their articles, and the success that those practices had in increasing coverage by newspapers. Editors of 120 medical journals published worldwide with clinical relevance were surveyed; the response rate was 54%. Eighty per cent of respondents reported that their journal offered journalists at least one of press releases, access to full‐text articles, or press conferences. Editors whose journals used the practices in conjunction with an embargo reported higher‐quality news coverage than editors of journals that did not, but editors and journalists held differing views about the justifications for the specific practice known as an embargo.     

Going Mental: Podcasting,Authenticity, and Artist–Fan Identification on Paul Gilmartin's Mental Illness Happy Hour

The podcast has recently emerged as a popular medium for comedians. It would not be accurate to describe the podcast as a wholly new, liberating medium that dispenses of all commercial logic in favor of the truly authentic, but it would be equally disingenuous to discount the feelings of empowerment and personal stability that the podcast medium has initiated for these comedians. Since April 2011, Paul Gilmartin, a stand-up comedian, television show host, and actor has hosted the Mental Illness Happy Hour (MIHH), a self-help podcast for those suffering from depression, anxiety, and frustration. Gilmartin's podcast has attracted over a million listeners since it debuted and has inspired a devoted following, thriving message board, and the sort of unexpected career revival that surprised even Gilmartin himself. While the man behind the microphone might be a comedian, MIHH is sobering, reflective, and unvarnished in its earnestness. I argue that the constitution of audience within this podcast disrupts more conventional understandings of fan–celebrity interaction. It tests previously held assumptions and makes ambiguous the lines between performer and audience, audience, and self-help community.     

Vocational Education Students’ Generic Working Life Competencies: Developing a Self-Assessment Instrument

The current study reports on the process of developing a self-assessment instrument for vocational education students’ generic working life competencies. The instrument was developed based on a competence framework and in close collaboration with several vocational education teachers and intermediary organisations offering various human resource services. A first version of the questionnaire was presented to 26 students and 5 recent graduates who were asked to comment on the items. The pilot version of the questionnaire was completed by 826 students. Half of the data were used to explore the structure of the questionnaire (n?=?413) and the other half were used to confirm the structure (n?=?413). The results showed that 8 factors could be distinguished. Further analysis reduced this to 7 usable factors: empathy, listening, assertiveness, professional attitude, problem solving, cooperation ability and, planning and prioritising. The revised questionnaire containing 44 items was tested a second time to determine the stability and measurement invariance of the instrument. In total, 456 students from the first sample completed the questionnaire. The structure was confirmed and measurement invariance across students with and without working experience was established.     

Deploying information technologies for organizational innovation: Lessons from case studies

Organizations must innovate if they are to survive in today's fiercely competitive marketplace. In this paper, we explore how leading organizations are using emerging technologies to enable novel forms of ideation that can radically increase the sheer volume of ideas they explore. In addition, we outline how organizations use technologies to cost effectively manage this increased volume of ideas by optimizing generation, mobilization, advocacy and screening, experimentation, commercialization, and even the diffusion and implementation of ideas. Critical to this is the management of knowledge during the innovation process.     

OPINION QUALITY IN PUBLIC OPINION RESEARCH

In recent years, a number of new techniques have been developed—includingdeliberative polls and educational surveys—that attemptto gather measures of public opinion that is of higher quality(i.e. better informed or more deliberative) than that recordedin typical mass opinion surveys. This paper addresses severalgeneral sets of questions. What is meant by ‘quality’in public opinion? What criteria can be enumerated by whichthe quality of public opinion can be assessed? In grapplingwith these questions, the paper argues that conceptions of qualityin public opinion are inextricably bound to broader conceptionsof quality in democratic decision making, a complex processinvolving multiple phases and collective participants. In addition,a number of important contradictions and ambiguities underlieconceptions of quality in public opinion.     

Enabling transformation through critical engagement and reflexivity: a case study of South African academics

ABSTRACT

Scholars writing on agency argue that normally, individuals who experience social structures as comfortable will tend to want to reproduce them while those who experience these structures as oppressive will want to change them. This is a bleak outlook because it suggests that those in positions of power and influence are less likely to seek to overhaul the very system of rewards and punishments that benefits them. However, there are exceptions to this pattern: instances where those who experience the structures as comfortable, nevertheless, work at transforming them. This article introduces an alternative perspective to current transformation discourses by seeking to understand why such exceptions exist. It argues that critical engagement is an important dimension of such transformation, and examines how it interacts with reflexivity to shape individual choices and reformulate interest. Drawing on a hermeneutic phenomenological analysis of in-depth interviews with 10 academics who have been identified as agents of change at one university in South Africa, we reveal how individuals are able to shift their understanding of what is or is not in their interest in a context where raced, gendered and classed interests are deeply embedded in the fabric of the society. In such contexts, reflexivity and critical personal engagement with one’s context can lead to a shift in interest and then consciousness as the individual comes to see and experience things from a different vantage point, opening up the possibility for a changed relationship with the social structure and its constraints and determining influence.