Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

重大研究计划“非常规突发事件应急管理研究”的科学背景、目标与组织管理

近年来,非常规突发事件的发生频率不断增加。为提高我国政府和社会对非常规突发事件的应急管理能力,推进我国应急管理科学的发展,国家自然科学基金委员会于2008年启动实施了“非常规突发事件应急管理研究”重大研究计划。本文介绍了该重大研究计划的现实需求、科学背景,及其研究目标和主要内容,提出了组织管理工作的一些思路和安排,以便有关政府组织、学者和公众更好地了解和参与重大研究计划,促使研究工作和成果为我国应急管理工作提供有效科学支撑。     

隐性知识交流和转移与企业技术创新关系的实证研究

针对隐性知识的开发和管理问题,建立了隐性知识交流、隐性知识转移和技术创新之间关系的理论模型,并在理论分析的基础上提出12个研究假设。采用问卷调查法,运用AMOS5.0把从我国东西部地区的部分制造企业和研究所收回的255份有效正式问卷数据导入结构方程模型进行分析,对理论模型和研究假设进行了检验,并依据研究结论提出了相关的对策建议。     

战略联盟演化过程中的组织间学习特征研究

战略联盟中的组织间学习是一个复杂的动态过程,有效地管理联盟,实现组织间学习已成为企业重要的战略资产。在动态环境下,将学习的变革过程和联盟演化过程相结合的理论研究可以指导管理者更有效地管理联盟。本文通过总结联盟演化过程和组织学习的相关文献,从动态视角分析在联盟生命周期的不同阶段的组织间学习特征。在对联盟中组织间学习界定的基础上,归纳企业在加入联盟后不同阶段的学习特点,为我国企业联盟管理研究提供借鉴。     

移动数字图书馆现状及发展研究

从移动数字图书馆概念入手,分析数字图书馆开展移动服务的现状及不足,并对移动图书馆未来发展进行展望,认为随着移动数字图书馆的实现,将会对图书馆未来发展、信息公平问题、图书馆专业人才及人才培养、图书馆提升服务质量几个方面产生影响。     

高职院校师资队伍建设探讨

大力发展高等职业教育,是我国经济结构调整的要求,是建设人力资源强国的战略性措施。高职院校承担着推动高等职业教育发展的重要任务,任务的关键是“双师型”师资队伍建设,这是提高高职院校人才培养质量和水平,办出高职院校特色的关键。分析了高职教育师资队伍存在的问题,提出从明确院校定位、加大“软实力”培训投入比例,自主学习、参与实践课题、挖掘培训渠道等方面提高师资队伍素质,探讨高职师资队伍建设对策。     

中国和谐社会的价值取向初探——基于马克思主义政治哲学视野

中国建设和谐社会是我国特色社会主义发展中的重要步骤和战略安排,在这样的历史进程中,建立与和谐社会相适应的马克思主义政治学不仅是中国现实的需要,也是中国未来和谐社会的实践基础。利用马克思主义的基本原理,分析中国特色社会主义和谐社会,解释和展望中国和谐社会的建设途径,是构建指导我国和谐社会建设的马克思主义的政治哲学发展需求,也是和谐社会最基础的研究领域。     

关于一类具有垂直传染与治疗SIR模型产生后向分支的研究

考虑了有限治疗资源和垂直传染的一类传染病模型,当染病个体数量小于某确定值时,治疗康复人数与染病个体数成比例;当染病个体数量大于某确定值时,治疗康复人数是确定常数值.确定了模型的基本再生数R0.在一定条件下,当R0〉1时,地方病平衡点E＊是渐进稳定的;当R0〈1时,后向分支就产生了.     

一种动态梯度式的学生网络管理员队伍的建设与管理

本文以阿坝师专现有校园网络管理为背景,以提高网管中心工作效率和服务质量,增强学生社会实践能力和网络技术水平为目的,提出了一种动态梯度式的学生网络管理员队伍的建设与管理模式,该模式在高职高专的校园网络管理中具有一定的通用性。     

Students’ intention to take online courses in high school: A structural equation model of causality and determinants

Offering an online integrated high-school course or subject for the first time involves many challenges. Better understanding the factors that affect students’ willingness to participate in the experience could provide support for better implementation of such a strategic initiative. In addition, it is important to understand how personal factors can influence the success of such an endeavour. This study develops a comprehensive structural equation model that captures most causal factors related to offering a high-school course online for the first time. A sample of public and private secondary school students (Grades 10, 11 and 12) in Abu Dhabi were administered an online survey regarding offering free online courses. The instrument was reviewed by other experts in curriculum, information technology and teaching and learning. The final instrument contained dimensions related to student perception of ease of use of e-learning, usefulness, self-efficacy, skills, style, student self-reported performance in certain subjects, use of social media, school support, teacher support, general support, access to the internet, and preferences behavioural intentions to use e-learning. The analysis provides a structural equation model with acceptable statistical fits and with many significant causal relationships. The paths representing direct and indirect effects of the construct predictors on intention to use provided statistical evidence of the validity of the 13 component predictors. Results show significant links between intention to use e-learning, perception of easiness, perception of usefulness, and other factors such as user characteristics and support. Use of social network affect intention to use e-learning indirectly thorough other variables. Limitations and implications of the study in general and as it concerns Abu Dhabi are highlighted.