排序方式: 共有9条查询结果,搜索用时 15 毫秒
1
1.
Upendra Yadav Pradeep Kumar Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(1):23
Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity. Reduced catalytic activity of enzyme leads to high homocysteine concentration in blood and increases risk for numerous diseases. The frequency of A66G polymorphism varies in different ethnic groups. The present study has been designed to evaluate the frequency of MTRR A66G gene polymorphism in the Eastern UP population by PCR–RFLP method. Along with this we also performed a meta-analysis to evaluate the global prevalence of this polymorphism. Databases were screened to identified the eligible studies. The prevalence of the G allele and GG genotype was determined by the use of prevalence proportion with 95% CI. Open meta-analyst software was used for the meta-analysis. Total 1000 blood samples were analyzed, the frequencies of A and G alleles were 0.35 and 0.65 respectively. Meta-analysis results revealed that the prevalence of G allele and GG genotype were 49.4% (95% CI 40.6–58.1, p ≤ 0.001) and 24.3% (95% CI 17.8–30.9, p ≤ 0.001) respectively. In sub-group meta-analysis, the lowest frequency of G allele was found in South America (32.7%; 95% CI 14.1–51.3, p ≤ 0.001), and highest in Asia (56.4%; 95% CI 39.5–73.3, p ≤ 0.001). The results of the meta-analysis showed that the Asian population has the highest frequency of G allele and highest frequency of the GG genotype was found in the European population. 相似文献
2.
超临界CO2做发泡剂制备多孔尼龙66膜的研究 总被引:1,自引:0,他引:1
超临界CO2做发泡剂制备多孔膜尼龙66,通过X射线衍射、扫描电镜和水通量的方法对膜结晶度、孔形态和水通量进行了表征.超临界CO2的作用促使膜结晶度提高,得到胞腔状开孔结构膜. 相似文献
3.
POE官能化及其增韧PA66的研究 总被引:1,自引:0,他引:1
采用在熔融挤出过程中提高双螺杆挤出机螺杆转速的方法,研究了机械力引发甲基丙烯酸缩水甘油酯(GMA)熔融接枝弹性体POE的接枝反应。红外光谱法分析的结果表明,随着螺杆转速的增加,接枝产物的接枝率出现先下降后增大的变化趋势,接枝产物的熔体流动速率(MFR)在螺杆转速n≥400 r/min时出现显著增大;随着接枝反应温度的增加,产物接枝率和熔体流动速率均明显增大。一定条件下,制得具有一定接枝率(红外表征)和较好熔体流动性(MI=0.8~14.0 g/(10 min))的接枝产物(POE-g-GMA)。材料力学性能测试和试样断面SEM分析结果表明,此接枝产物POE-g-GMA对PA66具有较好的增韧作用,可使PA66/POE-g-GMA共混材料的缺口冲击强度达到原未改性材料的8倍。 相似文献
4.
目的:探讨原位检测内源性基因表达产物的灵敏方法,研究IgA样新基因SNC66在消化系统肿瘤组织中的表达及其与肿瘤之间的相关性。方法:在组织切片原位逆转录反应后进行原位PCR扩增,在扩增过程中掺入地高辛标记的尿核苷酸,再用免疫组织化学的方法加以检测。比较SNC66在大肠癌、胃癌、肝癌组织与相应的正常配对组织中的表达情况。结果:10个循环时,37例大肠癌标本中有14例呈阴性,18例弱阳性,5例强阳性;20例胃癌标本中有6例呈阴性,9例弱阳性,5例强阳性;所有肝脏组织和肝癌标本都呈阴性表达。25个循环时,大肠癌10例阴性,27例强阳性;胃癌4例阴性,16例强阳性;所有肝脏组织和肝癌组织标本都呈阳性表达。相应大肠粘膜和胃粘膜标本则无论是25个循环,还是10个循环,都呈强阳性表达,但着色程度前者高于后者。结论:原位RT-PCR是一种检测内源性基因低拷贝转录产物mRNA的灵敏方法。基因SNC66是一个消化道肿瘤相关性基因,在大肠癌和胃癌组织中存在明显的表达降低或缺陷,但与肝癌之间不存在相关性。SNC66可作为侯选的消化道肿瘤的抑癌基因加以进一步研究。 相似文献
5.
最近的理论研究表明,氮笼分子内含有多个五元环和三元环、具有柱形结构和较多数量的层是分子稳定的因素。文章对纯氮氮笼N66(具有D3h对称性)的分子结构和能量在B3LYP/cc-pVDZ计算水平下进行探究。为了更全面地理解N66分子的结构,我们进行了NBO和AIM分析,结果表明,分子内的色散力是较大氮笼分子N66稳定性的一个重决定性因素。 相似文献
6.
We present a novel approach to teaching astronomy and planetary sciences, centered on visual images and simulations of planetary objects. The basic idea of the Thinking Journey concept is to take the students to other celestial objects as tourists, and to teach science through the observatio of various natural phenomena in these new environments. The power of scientific visualization, through still and dynamic images, makes such a journey an exciting learning experience. The introduction of new technologies (3D animations, virtual reality) greatly enhances the visualization capabilities the teacher can use, allowing him to simulate actual flights over the terrain of other planets and to study them as if observing from a spaceship in orbit. The present program focuses on the study of the Moon and of the planet Mars, by means of observation, interpretation, and comparison to planet Earth. Students learn to recognize geological and atmospheric processes, discuss astronomic phenomena, and discover that the same basic physical laws govern all objects in the solar system. 相似文献
7.
孙健 《北京体育大学学报》2016,39(2):140-144
摘要:古典式摔跤竞赛规则修改后对技战术的影响还未进行深入研究,为了把握古典式摔跤技战术发展趋势和备战巴西里约奥运会的需要,运用文献资料、观察、数理统计、比较分析、专家访谈等研究方法,以世界男子优秀古典式66kg级摔跤运动员为例,对新规则下古典式摔跤技战术的运用特征和发展趋势进行研究与探讨。结论:世界优秀男子古典式摔跤66kg级运动员站立与跪撑角斗得分能力均衡;转移与抱折是站立角斗的核心得分技术,逼迫对手消极成为站立得分的手段之一;滚桥和提抱技术是跪撑角斗得分的主要手段;站立对抗中积极、主动的进攻成为新规则下古典式摔跤的风格特点。建议:中国摔跤运动员整体对抗能力与世界高水平运动员还存在差距,教练员需加强运动员个人能力与技术风格的培养,在训练中以突出核心技术运用得分能力、加强站立对抗的积极主动性为目标指导训练与比赛。 相似文献
8.
Schwar 《Zeitschrift für Hochschulrecht, Hochschulmanagement und Hochschulpolitik: zfhr》2007,6(4):129-130
Die in § 3 Abs 1 3. Satz UniAkkG begründete Berechtigung der akkreditierten Privatuniversit?t, an die Absolventlnnen der an
ihr durchgeführten Studien akademische Grade (auch in gleich lautender Bezeichnung mit den im Universit?tsbereich geregelten
akademischen Graden) zu verleihen, bezieht sich nur auf die Verleihung akademischer Grade auf Grund der an der Privatuniversit?t
absolvierten Studien und umfasst mithin nicht die Verleihung von Ehrendoktoraten. Das Fehlen einer Erm?chtigung zur Verleihung
von Ehrendoktoraten im UniAkkG verwehrt die Annahme, dass akkreditierte Privatuniversit?ten berechtigt sind, akademische Ehrungen
nach Art der in § 82 UOG 1993 genannten zu vergeben. 相似文献
9.
在组织切片上进行原位RT-PCR扩增(in situ RT-PCR),并在扩增过程中掺入地高辛标记的尿嘧啶核苷酸(Dig-UTP),观察新基因SNC 66在胃癌组织与正常胃粘膜中的表达差异,以分析SNC 66与胃癌发生的相关性。结果发现,25个循环时,20例胃癌标本中有4例阴性不表达,16例呈强阳性表达;当循环数降至10时,则6例呈阴性,9例呈弱阳性表达,另有5例呈强阳性表达。表明SNC 66基因在胃癌组织中存在明显的表达降低或表达缺陷,SNC 66可能是一个消化道肿瘤的负相关基因。 相似文献
1