Treatment and follow-up of children with transient congenital hypothyroidism

Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH).Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4).Follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland morphology, bone age, growth development and development quotients (DQ). A full check-up was performed at age 2, when the affected children first discontinued the L-T4 treatment for 1 month, and one year later. Development quotients were compared (16.25±3.87) μg/d. Mean duration of therapy was (28.09±9.56) months. No significant difference was found between study group and control group in the DQ test (average score (106.58± 14.40) vs (102.4±8.6), P＞0.05) and 96.49% of the CH children achieved a test score above 85. Bone age, 99mTc scans and ultrasonographic findings were all normal, and evaluation of physical development was normal too, as were the serum levels of TT3, TT4 and TSH after one year of follow-up. Conclusion: A L-T4 dosage of and physical development at age 2. So it is possible for CH children to stop taking medicine if their laboratory findings and physical development are all normal after regular treatment and 2～3 years of follow-up.     

我国首个氟喹诺酮类创新药物“盐酸安妥沙星”研制成功

氟喹诺酮（沙星类）是目前我国抗菌药物3大主力品种之一,市场规模达100亿元左右,对保障我国人民身体健康发挥着重要作用。上海药物所杨玉社研究员、嵇汝运院士及团队从1993年开始,对氟喹诺酮类抗菌药物合成方法学、构效关系、成药性等开展了深入系统的研究工作。他们采用结构优化的策略,潜心研究左旋氧氟沙星的基因结构．药效关系、结构一代谢特征关系、结构一毒性关系,合成了一系列新的化合物,最终筛选出具有新化学结构的氟喹诺酮类抗菌药物——盐酸安妥沙星。该药在2008年8月申报国家“重大新药创制”重大科技专项时,获得审评专家的高度认可,评分列为化学类新药第一名。并于2009年4月15日获得国家食品药品监督管理局颁发新药证书,即将上市。     

On extending the concept of double negativity to acoustic waves

INTRODUCTION At this moment, novel concepts of “negative” media, having negative refraction and/or “double negativity” and their physical consequences and plausible applications are drawing considerable at- tention from the science and engineering community. In the past few years, considerable progress has been made in electromagnetic (EM) waves. It is our wish to generalize such concepts to acoustic waves. Since the concept of negative refraction, negative constitutive relationships…     

Analytical solution for electromagnetic scattering from a sphere of uniaxial left-handed material

INTRODUCTION The concept of left-handed materials (LHM for short, also called negative index materials) was in- troduced by Veselago (1968). An LHM has both negative permittivity and negative permeability, which makes the wave vector, the electric-field vector, and the magnetic-field vector in the LHM obey the left-hand rule. Experimental verifications for the existence of an LHM were made and its use as a perfect lens was suggested (Pendry, 2000; Shelby et al., 2001a; 2001b; Smith …     

蜗牛壳螺纹里的秘密

蜗牛天生有一道保护自己的坚实屏障,那就是它们身上的壳。一直以来,大家认定所有蜗牛壳上的螺纹都是右旋的。可是不久前有科学家发现,在日本有一种数量远远多于其他种类的蜗牛叫萨摩蜗牛,它们外壳上的螺纹竟然都是左旋的。这一奇怪的现象引起了科学家们的高度关注。     

网球左旋发球和右上旋发球技术探析

探讨了左旋发球的可行性及其方法,指出了它是我国网球运动员追求发球多变性,以弥补力量与速度不足的重要方法之一。同时,也对右上旋发球的技术动作实质和它的随挥方向进行了解析。     

江永《翼梅》宇宙论中的“理气”解

清代经学大师江永的西学研究已引起学界广泛关注,但对于其西学研究中的理学背景,关注尚有不足。本文以江永《翼梅》中若干西方宇宙论问题为例,分析了传统"理气"在江永西学研究中的应用及意义。     

植物也有“左撇子”

<正>你知道人有左撇子,可是你知道动物和植物也有"左撇子"吗?最近,科学家发现,猫、狗、猩猩、鹦鹉还有一些海洋动物都像人一样会惯用左"手"或右"手":大多数猫会用左前爪玩耍;寄居蟹的左钳更大;鹦鹉习惯用某一边的爪子捡拾物体;鱼在躲避天敌时也会有向左或向右的习惯;驼背鲸在进食时倾向用右颚;狗在放松的时候会向右摆尾巴,而焦虑不安的时候则会向左摆……     

蜗牛中的“极品飞车”到底能跑多快

3D动漫大片《极速蜗牛》是一部充满了励志和搞笑的电影,一只慢吞吞的花园蜗牛(garden snail)热爱速度,怀着这份逆天的理想,它开始了冒险之旅……奇遇之后,它还真获得了"超级速度"!不过,真实的蜗牛到底能跑多快,运动能力有多强呢?     

左旋氨基酸起源之谜：或与早期太阳光照有关

腾讯科学讯（Everett／编译）据国外媒体报道,众所周知,地球上的氨基酸几乎都是左旋,作为生命组成的基本单位,20多种氨基酸几乎都具有手性的特点,除了极少数生物体内存在右旋氨基酸外,