Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats

The histopathological features and the associated clinical findings of ulcerative colitis (UC) are due to persistent inflammatory response in the colon mucosa. Interventions that suppress this response benefit UC patients. We tested whether sodium arsenite (SA) benefits rats with dextran sulfate sodium (DSS)-colitis. The DSS-colitis was induced by 5% DSS in drinking water. SA (10 mg/kg; intraperitoneally) was given 8 h before DSS treatment and then every 48 h for 3 cycles of 7,14 or 21 d. At the end of each cycle rats were sacrificed and colon sections processed for histological examination. DSS induced diarrhea, loose stools, hemoccult positive stools, gross bleeding, loss of body weight, loss of epithelium, crypt damage, depletion of goblet cells and infiltration of inflammatory cells. The severity of these changes increased ir the order of Cycles 1,2 and 3. Treatment of rats with SA significantly reduced this severity and improved the weight gain.     

中草药提取液对柑橘溃疡病菌体外抑制活性

研究50种中草药水提取物和乙醇提取物对柑橘溃疡病菌的体外抑制活性.结果表明,山茱萸、诃子、地榆、枳实、蔓荆子、覆盆子和马兜铃7种中草药水提物和乙醇提取物对柑橘溃疡病菌具有明显抑制活性.其中以诃子提取物抑菌效果最好,水提液和醇提液在药物浓度5 g/m L时,抑菌圈直径可达3.8 cm和4.4 cm;地榆、枳实抑菌效果次之.该研究可为开发植物源控制柑橘溃疡病菌杀菌剂奠定基础.     

上海交大发明伤口治疗仪并量产 外伤不再久治难愈

伤口久治难愈是外科医生面临的难题,也给外伤患者带来巨大痛苦。一份资料显示,我国外科住院患者中,因难愈性的皮肤慢性损伤或溃疡需要住院治疗的患者约占1.5%,其中糖尿病溃疡占36%,且比十年前增加了6倍。