我院教职工腹部B超体检结果分析

重庆教育学院卫生科对450名教职工进行了腹部 B 超体检,分析体检结果发现,肝脾大、胆道结石及实质性脏器占位病变均以老年组发病率最高。本院胆道结石发病率9.8%,与重庆交通学院庹氏报道接近,而明显高于重庆建筑高等专科学校吴氏的报道,且以40岁以上、女性、高血脂、肥胖者为主。     

白饭树水提物对实验性肝损伤的保护作用

白饭树(Flugea virose(Roxb ex willd) Baill [F, mierocarna Bl.])水提物对CCl_4造成的小鼠、大鼠急性肝损伤具有明显的保护作用,可使中毒鼠血清中GPT,GOT,ALP,LDH等酶的含量显著下降或趋于正常;对CCl_4所致肝脏脂质过氧化作用具明显的缓解作用,并提高CCl_4损伤肝的解毒能力.     

亚洲首例机器人辅助活体供肝移植手术成功

正上海中山医院3月6日披露,该院成功完成亚洲首例"机器人"辅助成人-幼儿活体供肝移植手术:31岁的80后妈妈小杨成功捐肝给其20个月大的宝宝。妈妈小杨如今看上去神采奕奕。她表示,听起来骇人的取肝手术对她来说,就如同当年的剖腹产手术,伤口不仅不太疼,而且很隐蔽。今后去沙滩度假都不用担心。中山医院院长、肝外科专家樊嘉告     

李兰娟 院士

中国工程院院士、教授、主任医师、博士生导师。从事传染病临床、科研和教学工作30余年,是我国著名的传染病学家。作为我国人工肝的开拓者,她创建独特有效的人工肝支持系统治疗重型肝炎获重大突破。     

胃切开术对中华田园犬肝肾功能的影响

目的:通过研究胃切开术时中华田园犬血清谷草转氨酶、γ-谷氨酰转移酶活性、尿素、肌酐、尿酸含量的变化,评价胃切开术对犬肝、肾功能的影响,为有效实施术后护理奠定基础。方法:选择体重、年龄相近的中华田园犬6只(♂3,♀3),从实施胃切开术开始计时,分别在0、0.5、1、2、4、12h颈静脉采非抗凝血2mL,4℃静置12h,3 000r/min离心10min,取上清液,测定血清中谷草转氨酶、γ-谷氨酰转移酶的活性,以及尿素、肌酐、尿酸的含量。结果:与0h相比,12h血清中的谷草转氨酶活性显著增加(P0.05),0.5、1、2、4h血清中谷草转氨酶的活性无显著变化(P0.05)。0.5、1、2、4、12h各时间点血清中谷草转氨酶的活性无显著变化(P0.05)。各时间点血清中γ-谷氨酰转移酶活性、尿素、肌酐、尿酸含量均无显著差异(P0.05)。结论:胃切开术对中华田园犬血清中的谷草转氨酶的活性有一定影响,而对γ-谷氨酰转移酶的活性,以及尿素、肌酐、尿酸的含量无显著影响,手术过程中应当密切关注手术应激对肝功能的影响。     

静电场对力竭运动后大白鼠肝糖元恢复的影响

对力竭运动后大白鼠,在五种不同的静电场中暴露0.5h,观察不同静电场对机体肝糖元恢复的影响。     

茜草对耐力训练后一次力竭大鼠血清酶活性和某些生化指标的影响

为探讨茜草提取物对大强度耐力训练大鼠血清生化指标影响的机理,为茜草提取物作为运动补剂提供实验依据.利用ACE全自动生化分析仪、分光光度计等,测定了运动训练大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)活性、血糖(Glu)浓度、血红蛋白(Hb)、血清尿素(BU)、和肌肝糖原含量.结果表明:茜草提取物可保护重要器官免受自由基的损伤;增加肌肝糖原的含量;可明显延缓大鼠运动疲劳的发生.     

A novel way of liver preservation improves rat liver viability upon reperfusion

Background/aim： Currently, the liver is cold-preserved at 0-4 ℃ for experimental and clinical purposes. Here, we investigated whether milder hypothermia during the initial phase of the preservation period was beneficial for liver viability upon reperfusion. Methods： In the first set of experiments, rat livers were preserved either conventionally in clinically used histidine-trypthopan-ketoglutarate （HTK） solution （Group A： 45 min and Group B： 24 h） or by slow cooling HTK solution （from 13 ℃ to 3 ℃） during the initial 45 min of preservation （Group C： 24 h）. In the second set of experiments, additional groups of livers were evaluated： Group BB-preservation according to Group B and Group CC-preservation according to Group C. Further, some livers were preserved at 13 ℃ for 24 h. Livers were then reperfused using a blood-free perfusion model. Results： Bile production was approximately 2-fold greater in Group C compared to Group B. Alanine transaminase （ALT） and aspartate transaminase （AST） release into perfusate were 2-3-fold higher in Group B compared to Group C. No significant differences were found in ALT and AST release between Group C and Group A. Livers in Group CC compared to Group BB exhibited significantly lower portal resistance, greater oxygen consumption and bromosulfophthalein excretion into bile and lower lactate dehydrogenase （LDH） release into perfusate. Histological evaluation of tissue sections in Group BB showed parenchymal dystrophy of hepatocytes, while dystrophy ofhepatocytes was absent in Group CC. Livers preserved at 13 ℃ for 24 h exhibited severe ischemic injury Conclusion： These results suggest that the conventional way of liver preservation is not suitable at least for rat livers and that slow cooling of HTK solution during the initial phase of cold storage can improve liver viability during reperfusion.