Structural Aberrations of Cellular Sialic Acids and their Functions in Cancer Metastases

Sialic acids (neuraminic cids)are a special series of 9-carbon ring negatively charged carbohydrates,which has been found to be selectively changed in malignant cells from structures(both synthesis and structure modifications)to functions(up and down regulation in cells),Sialic acids,in single forms or conjugates.have been systematically studied both in lab and in clinics by GC,GCMS,NMR,HPTLC,HPLC and other modern analytical means.Sialic acids and related conjugates are predicted to be used in cancer diagnosis,cancer prognostic forecasting,designing of cancer chemotherapy regimens,uncovering carcinogenetic processes and neoplasm metastasis.Tumor cell regulative system and pathways are correlated with sialic acids,which can be applied to prognostic evaluation of cancer patients,and antimetastatic chemotherapy by sialic acid derivatives and analogues,Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days.In this paper,main stream discoveries and advancements are provided.also discussions of possible mechanisms and hypotheses are invoked.     

简析网络热词“XX癌”

随着网络语言的快速发展,最近,"XX癌"成为网络热词,常用的是"直男癌"、"懒癌"、"钱癌"、"尴尬癌"、"屌丝癌"等,本文通过对比分析"癌"的新旧词义、所指对象、构词法,并联系社会、心理,深入挖掘"XX癌"成为网络热词的原因。     

癌的多重抗药性

用化学疗法治癌失败后可能会怪罪到一种古老的、把毒素从细胞里清洗出去的泵蛋白。找到这种泵蛋白就有希望使具有多重抗药性的癌再次能用药物来治疗。     

医药卫生

一种新型的可检测不同人工晶状体植入术后功能视力的模型眼；口腔鳞癌中Bax，Bcl-2和Survivin蛋白表达与预后相关性研究；变形链球菌基因组研究进展；下睑缘入路治疗眶内下壁联合骨折；喉鳞状细胞癌Paxillin表达的临床意义；SLE基因芯片表达谱研究进展。     

几丁质对肿瘤及免疫作用的实验研究

采用微晶几丁质，观察其对小鼠肿瘤的抑制作用及对免疫功能和细胞毒性的影响。结果显示：经灌胃途径给予剂量为４００ｍｇ／ｋｇ的几丁质制剂，具有延缓小鼠腹水瘤生和作用；对小鼠实体瘤Ｓ１８０生长具有抑制作用，其抑瘤率达３３％。研究还表明，几丁质对小鼠腹腔巨噬细胞的吞噬功能具有明显的促进作用；对人二倍体２ＢＳ细胞和小鼠骨髓瘤ＳＰ２／０细胞地直接     

美研究员“误打误撞”发现治癌新疗法

新美国一名研究人员在进行药物试验时因操作失误，放入过多药物，结果导致自己辛苦培育的癌细胞死亡。尽管最初的试验目的没有达成，但这次试验室“事故”却帮助研究人员意外发现一种治癌新疗法，开始转向研究一种可以杀死癌症细胞的新药。