A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge

Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with ‘catatonic depression’ and admitted to a residential mental health facility. She was referred to our hospital for further investigation 3 months later. Heteroanamnesis revealed that the symptoms had been evolving progressively over several months. Magnetic resonance imaging (MRI) of the brain showed diffuse symmetrical white matter lesions in both hemispheres. Routine laboratory tests including vitamin B12 and folic acid were normal except for a slight normocytic, normochromic anaemia. Over the next 6 weeks her symptoms deteriorated, and she became unresponsive to stimuli. A new MRI scan showed progression of the white matter lesions. The neurologist requested plasma homocysteine (Hcys) which was more than 8 times the upper limit of normal. Further testing revealed increased methylmalonic acid and the patient was diagnosed with adult-onset cobalamin C deficiency. This case illustrates that Hcys and/or methylmalonic acid should be determined in patients presenting with neuropsychiatric symptoms suggestive of vitamin B12 deficiency with a normal serum vitamin B12 to rule out a late-onset cobalamin C deficiency.     

基于FPGA技术的8B/10B信道编码设计

该文在分析8B/10B编码原理的基础上,设计了改进型8B/10B编码方案.该编码在完成高速数据信道编码功能的同时,可另外提供一路实时低速信道.基于FPGA技术采用查表法实现了改进型编解码电路,通过仿真验证了该编码方案的有效性,并在Spartan6系列FPGA中进行了综合测试.结果表明,此编解码方法占用的FPGA逻辑资源...     

儿童焦虑与父母教养方式关系的调节变量研究

研究综合了来自中国大陆18570名3-12岁儿童的焦虑与父母教养方式相关的30项研究的数据,通过元分析的方法考查了二者相关的强度,并分析影响相关强度的因素。从总体上来说,儿童焦虑与父母教养方式存在弱相关;父母教养方式类型、儿童年龄、父母性别会对二者关系产生调节作用。建议在教养儿童过程中要采用正向的教养方式,要给予年幼儿童充分的独立自主的权利和自由,鼓励父亲参与教养,这有利于降低儿童的焦虑水平。     

基于政策文本视角的广东“十二五”科技政策研究

基于"政策年度""政策类型""颁布主体"和"文种类型"四位一体科技政策分析框架,对广东"十二五"期间颁布的80项科技政策样本进行统计分析,系统阐述广东"十二五"期间科技创新政策的类型分布、主要特点和存在问题,并提出若干对策建议。     

2008年欧洲杯足球赛决赛阶段各队进攻进球特征研究

通过对2008年欧洲杯足球赛决赛阶段31场比赛的73个进球特征统计发现:下半场进球数高于上半场,全场比赛结束前15min是全场比赛进球最高峰;进球方式是以脚射为主,其中,抢点直接脚射进球率最高;由前场发动组织进攻进球率最高;进球射门主要区域集中在罚球区;球门下部是进球入门的主要区域,尤其从球门右下角区域进球率最高;各位置进球数最多的仍是前锋运动员;边路进攻进球数位居各进攻形式之首;进球前经过2次传球配合后射门进球数最多,随运动员之间传球配合次数增多破门得分机率减小。     

单片机AT89C52扩展USB接口实现

本文在介绍USB接口基础上,提出一种AT89C52扩展USB接口的实现方法。并指出由于USB接口使用方便、支持热插热拔,AT89C52扩展了USB功能有利于进一步拓展其应用,因而具有广阔的应用前景。     

A review of Computer Science resources for learning and teaching with K-12 computing curricula: an Australian case study

To support teachers to implement Computer Science curricula into classrooms from the very first year of school, teachers, schools and organisations seek quality curriculum resources to support implementation and teacher professional development. Until now, many Computer Science resources and outreach initiatives have targeted K-12 school-age children, with the intention to engage children and increase interest, rather than to formally teach concepts and skills. What is the educational quality of existing Computer Science resources and to what extent are they suitable for classroom learning and teaching? In this paper, an assessment framework is presented to evaluate the quality of online Computer Science resources. Further, a semi-systematic review of available online Computer Science resources was conducted to evaluate resources available for classroom learning and teaching and to identify gaps in resource availability, using the Australian curriculum as a case study analysis. The findings reveal a predominance of quality resources, however, a number of critical gaps were identified. This paper provides recommendations and guidance for the development of new and supplementary resources and future research.     

第8届全运会摔跤比赛调研报告

本文对第8届全运会摔跤比赛的统计资料分析认为,我国摔跤的整体实力有提高,但教练员素质、运动员体能与跪摔技能等,有待进一步提高。     

第八届全运会游泳比赛述评

就第八届全运会游泳比赛分析我国游泳的整体水平及各队实力,指出中国游泳存在不容乐观的一些新问题,并希望中国游泳正视现状,扬长避短,迎接挑战,再创辉煌。