3-(6-溴吡啶-2)-2-(2-氟-6-氯苯)-噻唑酮-4的电子结构与抗HIV活性间关系的量子化学研究

采用AM1方法,对3-(6-溴吡啶-2)-2-(2-氟-6-氯苯)-噻唑酮-4(BPFCTZO)进行了量子化学计算,给出了分子的几何构型、原子的净电荷、键级、前沿分子轨道组成与能级、前沿轨道电子密度等参数.结果表明BPFCTZO分子的稳定构型呈蝴蝶状,噻唑酮环为主活性区,其上的2位C、4位N和6位O等原子很可能是其与RT酶作用的活性位点.     

L-fuzzy相对T-1,相对T0与相对次T0分离性

定义了L-fuzzy拓扑空间中的相对T-1，相对T0与相对次T0分离性，讨论了相对T-1，相对T0与相对次T0分离性的一系列性质．证明了相对T-1，相对T0与相对次T0分离性是遗传的、传递的、弱同胚不变的及可乘性等性质，并给出了一些例子。     

合成草莓酯的新型催化剂

综述了无机盐、无机酸、杂多酸(盐)、固体超强酸等催化剂催化合成草莓酯的实验情况.结果表明,硫酸铝、CuCl2 ·2H2 O、固体超强酸SO2 -4 -TiO2 /Al2 O3、活性炭固载硅钨酸等催化剂催化合成草莓酯的收率较高,具有一定的工业应用价值.     

R&D co-operation and innovation a microeconometric study on French firms

The scope of this paper is to report new empirical evidence on the determinants of R&D co-operation. Indeed, the literature on the capabilities of firms emphasises the role of knowledge in the performance and evolution of firms who use knowledge developed in others to build their own knowledge capital. R&D co-operation between firms is one of the many strategies by which this knowledge may be transmitted. Several theoretical models have stressed that R&D co-operation is more likely when the level of spillovers is high. While this supposition is used in many theoretical models, it has rarely been tested before. Our results do not lend strong support to this intuition. Indeed, our spillover variables (national pure spillovers, national rent spillovers and imports of machine tools), which were supposed to match the theoretical notion of spillovers used in these theoretical models have a positive but not a significant role when explaining R&D co-operation. The R&D co-operation increases with size and with R&D intensity, but not with market share. It also increases with the budget spent on paying license fees and on acquiring patents and labour from foreign firms. In this study, we also analyse the determinants of innovation. In more precise terms, we compare the effects of R&D co-operation to those played by traditional internal factors and those exerted by external, pure and rent spillovers on the innovation capacity of the firms. Our results show that the commercial success of innovations of French firms depends mainly on size, market share, R&D intensity and human capital. Inward FDI from industrialised countries exerts a positive and significant effect. The finding highlights the important role of the absorptive capacity of firms. Spillover measurements, such as the acquisition of machine tools, foreign patents, licenses, and technological opportunities have a positive impact on innovation.     

Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial and antiviral activity in vitro

BackgroundCecropin P1, acting as an antimicrobial, has a broad-spectrum antibacterial activity with some antiviral and antifungal properties. It is a promising natural alternative to antibiotics which is originally isolated from the pig intestinal parasitic nematode Ascaris suum. Many studies have shown that Cecropin P1 is helpful for the prevention or treatment of clinical diseases. Therefore, it is very necessary to establish a safe, nontoxic, and efficient expression method of Cecropin P1.ResultsThe results indicated that the recombinant protein was about 5.5 kDa showed by Tricine–SDS–PAGE and Western blot. And Cecropin P1 was efficiently secreted and expressed after 12 h of induction, with an increasing yield over the course of the induction. Its maximum concentration was 7.83 mg/L after concentration and purification. In addition, in vitro experiments demonstrated that Cecropin P1 not only exerted a strong inhibitory effect on Escherichia coli, Salmonella sp., Shigella sp., and Pasteurella sp., but also displayed an antiviral activity against PRRSV NADC30-Like strain.ConclusionsCollectively, the strategy of expressing Cecropin P1 in Saccharomyces cerevisiae is harmless, efficient, and safe for cells. In addition, the expressed Cecropin P1 has antiviral and antibacterial properties concurrently.How to cite: Jiang R, Zhang P, Wu X, et al., Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial and antiviral activity in vitro. Electron J Biotechnol 2021;50. https://doi.org/10.1016/j.ejbt.2020.12.006     

“大学域” 图书馆资源共享研究

随着高等教育规模的扩大，大学城在我国得到了迅速的发展。文章分析了大学城在我国产生的必然性，大学城资源共享的主要领域，提出了大学城图书馆之间可以在政策制定、协调采购、目录编制、馆际互借、对外交流和利用现代信息技术方面实现资源共享，分析了在资源共享方面存在的问题。     

国家治理信息机制的要素分析

文章认为信息机制不仅具有国家治理体系的属性,而且属于国家治理能力范畴,信息机制不仅是一种信息管理的制度安排,也是政府信息能力的体现。文章提出了价值观念、制度安排、组织实体和信息工具的信息机制四要素分析框架,阐述了信息机制四要素的内涵及相互关系,提出了在开放科学的理念引领下,构建信息、资源和处置权相配套的制度体系,加强多元协同的政策共同体建设,增强信息工具的公共物品属性,四要素综合协调,多维度发力的完善国家治理信息机制路径。     

基于5W1H分析的公共图书馆大字本图书阅读推广服务探究

大字本图书是低视力人群重要的信息来源和学习资源,公共图书馆作为大字本图书主要的馆藏地,肩负着大字本图书阅读推广服务的重要职责。通过5W1H分析法,提出公共图书馆大字本图书阅读推广服务对策,包括服务时间、地点的选择、服务团队的建设以及服务方法等,以期对公共图书馆开展大字本图书阅读推广服务有所帮助。     

高职高等数学"2+1"教学模式研究与实践

针对目前高职数学课程教学内容体系一成不变,教学方式单一,教学模式陈旧的现状,高职院校要转变教学思想,改革课程体系,以应用能力培养为主线,通过构建“2＋1”（二年理论教学＋一年实践教学）模式来提高教学效率,并通过改革教学方法和教学手段以保证“2＋1”教学模式的顺利实施。     

Habilitationsverfahren; Gutachten; Beweiswürdigung

Der Umstand, dass fünf Gutachten zum Ergebnis gelangt seien, die im Habilitationsverfahren vorgelegten Arbeiten würden die wissenschaftliche Qualifikation des Habilitanden iSd § 28 Abs 5 UOG 1993 erweisen, w?hrend nur eines eine gegenteilige Auffassung vertrete, besagt für sich nichts über die inhaltliche Richtigkeit der einen oder der anderen Auffassung. Eine Bindung der Beh?rde an die "klare Mehrheit" der in den eingeholten Gutachten vertretenen Auffassung besteht nicht. Vielmehr ist iSd § 45 Abs 2 des im Habilitationsverfahren anzuwendenden AVG der im Wege der Beweiswürdigung zu ermittelnde "innere Wahrheitsgehalt" der Ergebnisse des Beweisverfahrens ma?geblich, wobei die bei der Beweiswürdigung ma?gebenden Erw?gungen in der Begründung des Bescheides klar und übersichtlich zusammenzufassen sind.