展开式变奏在勃拉姆斯《D大调小提琴协奏曲》中的创作技法研究

文章通过对勃拉姆斯《D大调小提琴协奏曲》的详细剖析,从主题构建、呈示部创作、全曲整合多角度分析阐述展开式变奏在特定作品中的实际运用,并探析在这首作品中展开式变奏所呈现的独特创作技法,为研究勃拉姆斯创作手法中的创新性提供一定的参考。     

基于MIP-SLA的叶片陶瓷型芯光固化成型技术

为解决航空发动机空心涡轮叶片陶瓷型芯的3D打印难题,研究基于图像投影的复杂结构陶瓷型芯光固化成型（mask-image projection stereolithography,MIP-SLA）方法。搭建MIP-SLA工艺系统平台,对陶瓷浆料的制备和打印工艺参数的配置进行研究。分析利用球磨机将光敏树脂和陶瓷颗粒进行混合制备陶瓷浆料时,光敏树脂类型、固相含量、陶瓷颗粒粒径、分散剂含量和球磨时间对陶瓷浆料性能的影响。对不同配置参数下的打印效果进行对比分析,对确定的最佳打印工艺参数进行打印效果验证。     

Utility of P-SEP,sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation.     

Between-limb differences in running technique induces asymmetric negative joint work during running

Negative work, which is mainly generated by eccentric muscle contraction, has an important influence on the associated muscle damage. Generally, mechanical parameters are determined for one side of a lower extremity on the assumption of negligible between-limb differences. However, between-limb differences in the negative work of lower extremity joints during running remain unclear. This study examines between-limb differences in negative work and associated mechanical parameters during the contact phase of running. Twenty-five young adult males voluntarily participated in this study. Each participant was asked to run on a straight runway at a speed of 3.0?m?s^?1. Negative work, amplitude, duration of negative power, moment, and angular velocity were computed for both sides of the lower extremities. Significant differences were found in negative work between limbs for the hip (18.9?±?11.7%), knee (13.6?±?10.4%), and ankle (11.8?±?8.5%) joints. For the hip joint, asymmetric negative work was attributable to the between-limb difference in the amplitude of negative power owing to a corresponding difference in the moment. The between-limb differences concerning the duration and amplitude of negative power could explain the asymmetric negative work in the knee joint. The asymmetric negative work of the ankle joint was attributable to the between-limb difference in the amplitude and duration of the negative power and the moment. These results indicate that asymmetric negative work was generated in each lower extremity joint; however, the major mechanical parameters corresponding to the negative work are not the same across the joints.     

一种机载重轨InSAR高精度三维定位方法

在重轨干涉实际测量中,两次飞行航迹难以保持高度重合,飞行高度和姿态不稳定,干涉图像对存在明显不规则的相对形变,难以进行三维定位。通过分析重轨机载InSAR图像对的几何形变和形成原因,提出一种从精准的InSAR成像几何关系出发,通过修正成像参数,实现机载重轨InSAR高精度三维定位的方法。该方法通过引入地面控制点,实现干涉图像对精准的相对定位,生成高精度DEM;并利用高精度DEM,实现机载重轨InSAR高精度三维定位。对比检查点实测结果和定位结果,表明该方法可有效地解决机载重轨InSAR的三维定位困难的问题。     

Replication,pathogenicity, and transmission of SARS-CoV-2 in minks

Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts, and transmits efficiently in minks via respiratory droplets; pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19. We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks. Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.     

Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair

Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell–cell and cell–matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.     

P企业规模、研发强度、资助强度与政府科技资助的绩效关系研究——基于浙江民营科技企业的实证研究/P P /P P/FONT /P

政府科技资助的绩效已经引起国内外学者的极大关注。本文基于文献研究,建立影响企业R&D投入的实证模型,采用浙江省民营科技企业数据,测度了政府科技资助对企业R&D投入的影响。进一步,分别从企业规模、研发强度、资助强度等不同视角研究政府科技资助的激励效应,探索政府科技资助的激励机理,研究发现：政府科技资助对企业滞后一年的R&D投入有显著促进作用;企业规模越大,政府科技资助激励效果越好;政府科技资助强度越大,激励效果越好;企业研发强度影响政府科技资助激励企业R&D投入。     

模具专业机械制图课程的教学改革研究

文章提出以三维CAD软件为教学手段,整合教学内容,添加模具零件图、装配图等专业知识,结合企业真实案例的教学方法,对高职模具专业机械制图课程进行教学改革。实践证明,只有将理论和实践相结合,紧跟时代和企业步伐,才能改变传统的枯燥教学模式,提高学生的学习兴趣,为后续的课程打下坚实基础。     

研发团队知识协同动机研究——基于组织学习的视角

研究其内部知识协同的动机,对于企业更好的管理和激励团队成员积极参与知识协同具有十分重要的意义。本文基于组织学习的视角,从知识贡献者和知识寻求者两方面,探讨了影响研发团队成员主动参与知识协同的动机因素,并构建了理论模型。分析结果表明：个人声誉、共享意愿及群体认同对知识贡献者参与组织学习的动机具有不同影响;社会地位、渠道多样化及社会存在感对知识寻求者的主动性具有显著正向影响;应用性学习与探索性学习均对协同创新绩效有显著影响,且前者的影响大于后者;团队激励对组织学习和知识协同创新绩效间的关系具有干预调节作用。