IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies,biomarkers, and predicting cardiotoxicity

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been well-established as one of the few safe and effective interventions, leading to improved outcomes in patients. However, a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart failure. The insulin-like growth factor 1 (IGF1)–phosphoinositide 3-kinase (PI3K) pathway has been recognized as perhaps the most critical pathway for mediating exercised-induced heart growth and protection. Here, we discuss how modulating activity of the IGF1–PI3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the heart. We outline some of the promising approaches being investigated that utilize PI3K-based therapy for the treatment of heart failure. We discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3K activity. Finally, we discuss the use of animal models of cardiac health and disease, and genetic mice with increased or decreased cardiac PI3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.     

矩形花键拉刀三维参数化设计研究

本论文研讨了基于SolidWorks软件平台建立矩形花键拉刀三维参数化设计系统的设计思想和开发流程,同时讨论了基于ANSYS软件对矩形花键拉刀刀齿进行强度分析的方法,以期为拉刀设计提供先进的工具平台。     

细胞生长中的PI3K/Akt/mTOR信号通路及其与运动的关系

PI3K／Akt／mTOR信号通路在细胞生长过程中发挥关键性的调节和控制作用。由于其复杂性及研究方法和手段多样性，运动对其影响的研究结果也不一。综述了此信号通路在细胞生长中的重要作用及电刺激模拟运动、急性和长期的抗阻或有氧运动对其影响的研究结果。     

运动与解偶联蛋白3(UCP3)介导的线粒体活性氧代谢调控研究进展

解偶联蛋白3是线粒体内膜上的一种转运蛋白,研究证实解偶联蛋白3与线粒体能量代谢、线粒体活性氧生成及脂肪代谢等有关。就解偶联蛋白3的结构、分布、表达调控及其介导的线粒体活性氧生成等相关问题作一综述。     

“3P模式”在英语阅读教学中的运用

目前我国国内英语教学仍主要以传授语言知识为主，导致教学效率低下。其原因归纳起来不外在教材方面和教法方面，具体表现为体制固性、思维惯性以及相关部门的利益驱动所致，3P英语阅读教学模式则强调在阅读教学中尊重学生个人的兴趣，强调教学内容应该和社会现实生活合拍，从而真正地实现“以学生为本”的教学理念。     

网络环境下"3P模式"在英语听力教学中的应用

在高校英语教学中,听力教学是一门重要的基础课程,然而国内许多高校学生的英语听力能力相对薄弱,成了提升其语言综合运用能力的瓶颈。而无论是从现实必要性还是操作的可能性而言,“3P”听力教学模式都是网络时代提升大学听力教学效果的路径选择。     

浅述电子邮件系统

从电子邮件的发展、架构、运作原理及应用上系统地阐述了这一互联网的基本应用，介绍建构及维护E-mail服务器中可能遇到的备种问题，并提出了若干解决办法。     

三维模型库的设计思路

制作标准件和常用件的三雏模型库，可以使我们很方便、快捷地调用三维立体模型。介绍三维模型库的设计思路。     

1080~0直旋的运动生物力学分析

为了对1080°直旋动作进行技术诊断,本文研究了我国国技巧队6名男子技巧运动员的比赛动作,其中获世界技巧锦标赛或世界杯赛金牌2人,获银牌1人。高速摄影机频率为100格/秒,影片经数字化处理后按运动生物力学理论和方法进行了全面分析。     

Women as androgynous managers : A conceptualization of the potential for American women in international management

Women in international management, where are they? While many female managers appear to have the qualities necessary for international management, they have been implicitly and explicitly excluded from overseas assignments.This paper will begin by describing some of the dimensions on which the international business environment is different from the domestic United States environment. Research on the attitudinal and behavioral skills found to be associated with success in the international environment will be presented. It will be suggested that this list of international management skills goes beyond those characteristics generally associated with either the male or the female role in North America. The Model of the Androgynous International Manager will be introduced as a way of conceptualizing an appropriate orientation for the role of the international manager. The need for future research is delineated.The scope of the discussion is limited to the role of American 1 women working in multinational business settings around the world.