中药塌渍配合TDP红外线治疗阴囊急性湿疹的疗效观察和护理

目的:探讨外用中药塌渍联合TDP红外线照射治疗阴囊急性湿疹的疗效观察和护理体会。方法:选取诊断为急性湿疹患者150例,按随机数字表法分为两组,西药对照组采用口服盐酸西替利嗪治疗,中药观察组在对照组的基础上外用中药塌渍联合TDP红外线照射。比较两组的疗效。结果:观察组总有效率为100%,对照组为86.6%,观察组疗效明显优于对照组(P0.05)。结论:中药塌渍联合TDP红外线照射治疗阴囊急性湿疹可有效提高临床疗效,简便易于掌握,患者更易接受。     

Anomalous Activity Measurements of Creatine (Phospho) Kinase,CK-MB Isoenzyme in Indian Patients in the Diagnosis of Acute Coronary Syndrome

In the present study, the cause of suspected false-positive (anomalous) values for CK-MB activity, in Indian patients investigated for ACS. Total serum CK and CK-MB activity, serum Troponin I were measured and CK-MB as a percentage of the total CK activity (%CK-MB) calculated. CK-MB was also estimated using densitometry and CK-MB mass assay. Anomalous specimens were tested for the presence of CK isoenzymes. In 22 healthy subjects, 11 male and female, the %CK-MB ranged from 3.6 to 30.2. In 11 male patients, with proven ACS, the %CK-MB was from 4.0 to 17.5. The cut off for anomalous CK-MB activity values was set as >33.0%. In 35 patients with anomalies, total CK values ranged from 39 to 231 U/L, CK-MB from 30 to 161 U/L. Investigation of CK isoenzymes, showed 10 patients had a CK-BB band, 14 an intermediate band between CK-MM and CK-MB (macro-CK type 1), 7 had a cathodal band (macro-CK type 2), and 3 had a band intermediate between CK-MB and CK-BB. This later band does not seem to have been previously reported. Against the CK-MB mass assay, the activity assay showed no correlation, in 43 patients (19 M, 24 F), Pearson coefficient (R²) was 0.006. The CK-MB immunoinhibition assay is better described as measuring “non-CK-MM activity.” A %CK-MB activity >6% as a marker of ACS is not valid in our patient population. Laboratories should not use only CK-MB activity as a biochemical marker of ACS.     

纳米材料与农作物之间的相互作用：食品安全与启示

研究目的：通过综述作物对纳米材料的吸收途径和积累,以及纳米材料对农作物生长和营养的影响,为纳米污染在农业中的风险提供理论分析和启示。 创新要点：归纳了纳米材料被作物吸收的路径和对作物生理、遗传、营养各水平上产生的胁迫。重要结论：当前纳米与作物的研究应集中在食品安全相关的问题上,考虑农业实际情况和环境因素,分析纳米材料通过食物链富集和传递的可能性,探讨纳米材料与其他土壤有机污染物可能产生的复合污染。     

硫普罗宁治疗急性戊型肝炎的疗效观察

目的：观察硫普罗宁治疗急性戊型肝炎的临床疗效和安全性.方法：急性戊型肝炎患者65例,随机分为治疗组33例,应用硫普罗宁0.2g加入5%葡萄糖注射液200ml中静脉滴注,每日1次;对照组32例,常规应用护肝药物如肌苷注射液等静脉滴注,疗程均为2周.观察治疗前后两组的症状、体征及肝功能情况.结果：硫普罗宁治疗后患者临床症状和肝功能均有显著改善.两组比较发现,ALT 好转情况、显效率和总有效率差异均有显著性（P＜0.05）.结论：硫普罗宁治疗急性戊型肝炎有较好疗效,且未见不良反应,用药安全.     

Meta-analysis of <Emphasis Type="Italic">C242T</Emphasis> polymorphism in <Emphasis Type="Italic">CYBA</Emphasis> genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

Background

A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS.

Methods and results

We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64–0.83), dominant model (OR 0.71; 95% CI 0.62–0.82), and homozygote comparison (OR 0.57; 95% CI 0.35–0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test.

Conclusions

Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians.

     

Acute Renal Failure in Liver Transplant Patients: Indian Study

The acute renal failure is the frequent medical complication observed in liver transplant patients. The objective of this study was to determine the cause of acute renal failure in post liver transplant patients. A total of 70 patients who underwent (cadaveric 52, live 18) liver transplantation were categorized based on clinical presentation into two groups, namely hepatorenal failure (HRF, n = 29), and Hepatic failure (HF, n = 41). All the patients after the liver transplant had received tacrolimus, mycophenolate and steroids. We analyzed the modification of diet in renal disease, (MDRD) serum urea, creatinine and albumin before and after 5th and 30th day of liver transplant and data was categorized into survivors and non-survivors group. In HRF survivor group, serum creatinine, and urea levels were high and, albumin, MDRD were low in pre- transplant and reached to normal levels on 30th day of post transplant, and 79.3 % of patients in this group showed resumption of normal kidney function. On the contrary in HRF nonsurvivor group, we did not observed any significant difference and 20.7 % of patients showed irreversible changes after the liver transplant. In HF survivor group, 82.9 % of liver failure patients did not show any deviation in serum creatinine, urea, albumin and MDRD, whereas in HF non survivor group, 17.1 % of liver failure patients who had HCV positive before the transplant developed acute renal failure. The levels of creatinine, urea, albumin and MDRD were normal before the transplant and on day 30th, the levels of albumin and MDRD were significantly low whereas serum urea, creatinine levels were high. In conclusion, based on these observations, an diagnosis and treatment of Acute renal failure is important among the liver transplantation cases in the early postoperative period.     

急性应激对小鼠空间学习记忆功能及脑内NT-3表达的影响

目的：研究急性应激对小鼠空间学习记忆的影响及其机制。方法：以足底电击来建立急性应激小鼠模型，采用Morris水迷宫检测小鼠空间学习记忆能力，以免疫组化方法检测神经营养因子-3(NT-3)在小鼠海马和前脑皮层的表达。结果：水迷宫实验中，急性应激组小鼠与对照组相比，空间学习记忆显著提高(P<0.01)。在海马CA1区、CA3区、齿状回及前脑皮层NT-3的表达显著增强(P<0.05，P<0.01)。结论：急性应激所致小鼠空间学习记忆功能的提高可能与脑内NT-3表达上调相关。     

Effect of swim intensity on responses to dynamic apnoea

The aim of this study was to determine the influence of swim intensity on acute responses to dynamic apnoea. 9 swimmers performed one 50 m front crawl trial in four different conditions: at 400 m velocity (V₄₀₀) with normal breathing (NB), at V₄₀₀ in complete apnoea (Ap), at maximal velocity (V_max) with NB and at V_max in Ap. Peak heart rate (HR_peak), blood lactate concentration after exercise (Lac_{post ex}) and Borg rating of perceived exertion (RPE) were measured. Arterial oxygen saturation (SpO₂) was monitored with a pulse oximeter at forehead level during and after exercise. In Ap, swimming at V₄₀₀ induced a significantly lower HR_peak and Lac_{post ex} than swimming at V_max whilst RPE and the kinetics of SpO₂ were not different at V₄₀₀ and at V_max. The minimal value of SpO₂ in Ap was reached 10 to 11 s after the end of V₄₀₀ and V_max (81.7 ± 10.1% and 84.4 ± 10.6%, respectively). Swimming a 50 m front crawl in Ap resulted in a large decrease in SpO₂ which occurred only after the cessation of exercise. The higher duration of apnoea during submaximal exercise could explain why SpO₂ and RPE reached the same values as for maximal exercise.?     

Role of l-Arginine on Dyslipidemic Conditions of Acute Myocardial Infarction Patients

Oxidative stress conditions associated with atherosclerosis leads to oxidative modification of low-density lipoprotein (LDL). The body’s capabilities to inhibit LDL oxidation and to remove or neutralize the atherogenic oxidized LDL (ox-LDL) are limited. When the LDL cholesterol level increases in the blood, it leads to dangerous consequences like atherosclerosis, leading to myocardial infarction. The major effect of an antioxidant in the LDL environment is to prevent the formation of ox-LDL (during atherogenesis. Strategies to reduce LDL oxidation and prevent atherogenesis can involve the enrichment of arterial cells with potent antioxidants that can prevent oxidative damage to the arterial wall. The objective of this study is to evaluate the effect of l-arginine on serum lipid and cholesterol levels in the patients of acute myocardial infarction (AMI). The study consisted of 70 AMI patients and 60 healthy individuals (serving as control) age 55–65 years. Serum levels of total cholesterol, high density lipoprotein (HDL), LDL and Triglycerides were determined on day 1 and day 15 of l-arginine administration (oral dose 3 g/day). The total cholesterol/HDL and the LDL/HDL ratio were calculated and compared. As per the observations, l-arginine administration was found to improve the lipid profile of the subjects. Hence it could be used as an adjuvant therapy for AMI and as a preventive measure for the onset of the disease in the healthy elderly also.     

内给氧治疗急性出血坏死性胰腺炎47例疗效观察

目的：观察内给氧治疗急性出血坏死性胰腺炎的效果。方法：对2003．4～2006．4月收治的47例经血、尿淀粉酶、B超、CT证实为急性出血坏死性胰腺炎患者，随机分为治疗组和对照组，治疗组给予注射用内给氧＋善德定（善宁）或施他宁、抗生素及基础性支持治疗；对照组予善德定（善宁）或施他宁加抗生素及基础性支持治疗。结果：治疗组腹痛缓解时间、淀粉酶降至正常时间及死亡率均明显少于对照组，差异有非常显著性（P〈0．01）。结论：内给氧配合基础性治疗对重症胰腺炎有较好疗效，具有费用低，实用性强的优点。