RETRACTED ARTICLE: Frequency of TP53 Mutations and its Impact on Drug Sensitivity in Acute Myeloid Leukemia?

The purpose of this study is to find out the frequency of TP53 mutations in acute myeloid leukemia (AML) patients and correlate sensitivity of drug response with TP53 mutations. In AML more than 90 % of cases comprise of wild type TP53. 94.2 % of TP53 mutations are found within exon 5–8 of which 73 % are point mutations. TP53 mutations were analysed with high resolution melting curve analysis. We analysed 106 AML samples of which we found nine mutations which represents 8.5 % mutation rate and found one rare SNP. The effect of TP53 mutations were studied on the chemosensitivity of two new drugs AZD115 and RHPS4, an Aurora Kinase B inhibitor and Telomerase inhibitor respectively. Four mutations were found out of 17 for RHPS4 stating significant (p = 0.002) increase in sensitivity and no mutation found in AZD1152 database, but need more study to get definite conclusion.     

聚合酶链反应检测儿童急性呼吸道流感嗜血杆菌感染的研究

目的 :建立儿童急性呼吸道感染的PCR检测方法 ,并与常规方法进行比较。方法 :选择编码外膜蛋白P6基因作为靶片段设计引物 ,分别用PCR方法及常规培养法检测 78例急性呼吸道感染儿童。结果 :建立的PCR检测法可以检测 10～ 5 0个流感嗜血杆菌 ;78例急性呼吸道感染儿童中PCR方法检出 4 2株 (5 3.8% ) ,常规培养方法检出 33株 (4 2 .3% ) ,培养法检测阳性者PCR方法均为阳性。PCR方法较培养法有显著性差异。结论 :PCR方法检测呼吸道流感嗜血杆菌感染比常规方法更快速 ,更简便 ,更敏感。PCR方法检测流感嗜血杆菌有可能成为临床流感嗜血杆菌感染诊断的一种实用、理想的方法。     

有机磷中间综合征的认识现状

目的:通过对有机磷中毒中间综合征临床发病机制、诊断标准以及治疗方法等方面的研究,更加深入的了解本病前沿研究进展。方法:复习近10年来前沿研究进展加以对比分析。结论:近年来对有机磷中毒中间综合征的认识不断深入、早诊断水平的提高以及医学硬件软件实力的提高,其死亡率却并未明显改善,其已成为危重病领域关注的重要问题和急救医学研究的热点。讨论:有机磷中间综合征现今主要治疗方案为除复能剂、抗胆碱能药物等治疗措施外主要依靠呼吸机辅助呼吸的支持。同时目前对中间综合征的发生发展病理生理机制尚不清楚,多数研究也是以学说的形式呈现,在某些学说方面也存在一定的争议。对于中间综合征发病基础机制的研究对于疾病的认识和发展以及指导治疗具有非常重要的指导意义。     

Feeling states during exercise: Influence of individual differences in perceived evaluative threat

Abstract

The present study is designed to examine the influence of individual differences in perceived evaluative threat and baseline responses on changes in feeling states experienced during acute exercise in college-age women with high social physique anxiety. Thirty women with high social physique anxiety completed acute bouts of stationary cycling at either a self-selected or imposed intensity in both naturalistic fitness centre and laboratory environments. Multivariate analysis of changes in feeling states during exercise yielded a significant baseline×perceived evaluative threat×intensity interaction during exercise in the naturalistic fitness centre environment. Decomposition of this interaction revealed that, within the naturalistic environment, women with the least favourable baseline feeling states who perceived the lowest amount of evaluative threat during exercise demonstrated the greatest improvements in affect during self-selected intensity exercise. These findings suggest that, among women with high social physique anxiety, changes in feeling states reported during exercise are influenced by an interaction between baseline affective responses, the intensity of exercise, and environmentally induced perceptions of evaluative threat.     

A repeated-measures examination of organizational stressors,perceived psychological and physical health,and perceived performance in semi-elite athletes

ABSTRACT

Organizational stressors can undermine the psychological well-being and performance of athletes. Less is known, however, about how these relationships unfold over time and whether organizational stressors can impact upon perceived physical health. The current study, therefore, used a repeated-measures design to examine relationships between organizational stressors with components of perceived psychological (anxiety and depression) and physical (illness symptoms and missed training days via illness) ill-health, and perceived performance at the within-person level. Twenty-three semi-elite female rowers completed monthly measures of study variables for six-months. Multilevel models indicated that selection-related stressors positively predicted symptoms of perceived psychological and physical ill-health, and negatively predicted perceived performance. Conversely, coaching stressors negatively predicted symptoms of perceived psychological ill-health. Logistics and operations stressors positively predicted perceived performance, whereas goals and development stressors negatively predicted perceived performance. These findings demonstrate for the first time that, with a repeated-measures design, organizational stressors can predict components of perceived physical and psychological ill-health, and perceived performance at the within-person level in athletes. From a practical perspective, practitioners should incorporate these findings when diagnosing the need for, developing, and optimally implementing primary and secondary stress management interventions.