急性胰腺炎时血浆内毒素的变化及清下方的影响

本文是对急性胰腺炎血浆内毒素含量测定的前瞻性研究,共观察患者24例,入院时病情按 Ranson 指标分为轻、重二组并随机分为常规治疗组与加用中药清下方的中西医结合治疗组。对各自血浆中的内毒素含量进行组间及治疗前后对比,并以50名正常人作为对照组。结果显示:急性胰腺炎病例血浆内毒素含量为:0.174±0.123Eu/mL;正常对照为:0.0785±0.027Eu/mL,二者差异显著(P<0.05)。按病情分型,轻型组内毒素含量为:0.160±0.099Eu/mL,而重型组则达:0.261±0.169Eu/mL,两组间也有显著差异(P<0.05)。经中西医结合治疗可使血浆内毒素含量明显减少(P<0.05).但常规治疗前后的差异不明显(P>0.05)。研究表明:急性胰腺炎时可使血浆内毒素水平明显升高,其含量与病情的轻重程度关系密切。在常规治疗中加用中药清下方则有使血浆内毒素水平降低的作用。     

藻酸双脂钠对急性脑梗死患者纤维蛋白原、脂蛋白(a)的影响及疗效观察

目的：探讨藻酸双脂钠（PSS）治疗急性脑梗死患者血液成分变化及疗效。方法：急性脑梗死患者158例，随机分为两组。对照组：78例，常规治疗；治疗组：80例，在常规治疗基础上，应用藻酸双脂钠注射液100mg加入0．9％氯化钠静脉滴注，每日一次，连续观察14d。对比分析二组治疗前后脂蛋白（a）、血脂、纤维蛋白原等血液流变学指标．并动态观察治疗前后临床神经功能缺损评分。结果：藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL，与治疗前比较有显著性改变（P〈0．01或P〈0．05）；与对照组比较有显著性差异（P〈0．01或P〈0．05）．但对脂蛋白（a）无影响；近期预后较常规治疗组好（P〈0．05）．结论：藻酸双脂钠可改善血液高粘滞状态，起到降低纤维蛋白原、抗血小板聚集作用，可改善近期临床神经功能缺损程度。     

急性重症胰腺炎的临床治疗分析

目的研究急性重症胰腺炎(ASP)的临床治疗.方法对34例ASP的临床资料进行回顾性分析.结果全组34例,治愈27例,治愈率为79.41%.非手术治疗组治愈率为88.89%,手术治疗组治愈率为68.75%.结论ASP非手术治疗的治愈率明显高于手术治疗.早期诊断ASP对选择ASP的治疗方式及改善预后有重要意义.     

情景模拟教学法在急性左心衰患者急救护理综合实训中的应用

目的:分析急性左心衰竭病患急救护理采用情景模拟教学法的作用。方法:选择我校220例2016级护理专业学生为研究样本,研究时间均在2018年9月至2018年12月之间,采取随机排列表法将其分成组均110例的实验组以及常规组。予以常规组护生基础教学方式,予以实验组护生情景模拟教学法。教学结束后对比两组教学满意度、理论知识以及操作技能考核成绩。结果:实验组护生与常规组护生的理论知识得分以及操作技能得分分别是83.698.04分、71.4612.21分;96.563.19分、81.296.53分(P<0.05)。实验组在创新思维、分析能力、急救意识、学习积极性、合作意识以及急救技能提高方面满意度均高于常规组(P<0.05)。结论:针对急性左心衰病患急救护理采用情景模拟教学法提高护生学习积极性,有利于培养护生的急救意识与合作意识,提高护生急救技能,值得在教学中广泛推广。     

呼唤善感的心灵

语文新课程标准对学生提出了“感受”、“鉴赏”的发展目标,这意味着学生要有一种对语言文字及周围生活的敏锐的感受能力。换句话说,要学好语文,首先要学生善感一些。但当前教育状态下的学生,一方面由于沉重的学业负担和升学压力,累得几乎喘不过气来,更不知善感为何物;另一方面,网络、电视、物质享受和时尚潮流的不断电击使学生的触觉由敏锐变为迟钝:现实令人忧虑。     

当归醋酸乙酯提取物抗炎镇痛作用的研究

当归醋酸乙酯提取物及水煎液,能显著地降低醋酸所致小鼠扭体反应发生率,提高小鼠热板法痛阀;能明显降低二甲苯所致小鼠耳廓肿胀程度;对大鼠蛋清性足跖肿胀和小鼠腹腔血管通透性,也有明显的对抗作用。急性毒性试验未观察到明显的毒性反应。     

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity, che-mopreventative and insecticidal properties. In this study, the toxic effects of L. elliptica essential oil against Sprague-Dawley rat's red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125, 250, and 500 mg/(kg body weight), respectively, and the control group received distilled water. Full blood count, RBC osmotic fragility, RBC morphological changes, and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb), mean cell hemoglobin concentration (MCHC), mean cell volume (MCV), and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P<0.05), the values were still within the normal range. L. elliptica induced morphological changes of RBC into the form of echinoeyte. The percentage of echinocyte increased significantly among the treated groups in a dose-response manner (P<0.001). The concentrations of RBC membrane phospholipids and cholesterol of all treated groups were significantly lower than those of control group (P<0.001). However, the RBC membrane osmotic fragility and total proteins of RBC membrane findings did not differ significantly between control and treated groups (P>0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.     

Case Report: CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CDI9), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21 [2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AM L with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.     

CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21[2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.     

Web数据挖掘在急性高原病易感人群预测中的应用

将Web数据挖掘技术应用于急性高原病易感人群的预测中,通过Web技术与数据挖掘技术相结合,将分散于Web中的数据经过检索、清洗、处理后存储在专门的数据仓库中。在现有研究成果的基础上,提出一个简便、高效的急性高原病易感人群预测模型。