对单分子反应机理的探索

化学动力学的主要问题之一,是对单分子反应一级动力学作出解释.以Lindemann历程为基础,阐明单分子反应机理的动力学特征,并指出只有在整个反应是一级和三级混合在一起的降变过程,才是真正的Lindemann历程.     

传统成本与战略成本研究对象的区别

本文先从介绍战略成本会计的研究对象与传统成本的研究对象入题,又在各自描述传统成本会计和战略成本会计的研究对象之后,详细比较了两者的区别,进行了范围、计量方法和侧重点的比较。     

大学生涉跑猝死事件的体医融合防卫机制研究

近年来,大学生身体素质不佳,已成为"老大难",也是刻不容缓需要解决的问题,多地曾出现在体测、运动会、马拉松中晕倒甚至猝死事件,这给学校体育工作的开展带来不小的考验。带着因涉跑引起猝死的疑问,通过猝死案例分析,探究高校大学生猝死的病理学的非运动成因。研究认为：涉跑猝死的主因是先天性生理疾病,运动不是引发猝死的主要诱因,并提出了预防运动猝死的"堵疏结合"的医学监控策略和体医融合防卫机制构建方法。建议通过入校时医学筛查、跑前医学检查、跑中医学观察、猝死现场急救、跑后跟踪复查降低猝死风险;建立宿舍、运动场地、运动项目的全覆盖的心脏复苏志愿队伍,实施"黄金8分钟"内的急救生存链;建立学生、学校、政府、社会四方体育运动分级分类保险制度,从风险转移和人道主义援助进行关怀;建立涉跑猝死、猝死、非正常死亡的数据库,开展非正常死亡人员的病理学研究;建立全生命周期医学监控和健康安全宣传教育,形成全方位、全过程、全人员的体医融合防卫机制。     

CBA球员球场暴力行为的归因研究与治理省思 ——基于互动仪式链视角

运用文献资料法和逻辑分析法,以互动仪式链理论为视角,从文化资本互动与情感能量互动两方面对CBA球场暴力行为的发生机制进行研究。指出,赛前与赛中的互动仪式相互联系,赛前不良的互动仪式会将负向的情感能量带入比赛,使共享情感破裂,产生球场暴力现象。球员个体间情境互动会过渡到球队群际间,暴力行为会通过互动仪式链不断扩散到其他球队。比赛中双方都存在冲突性紧张,谁能抢占情感能量主导权谁就会在博弈中占据优势地位,处于压制的一方将转化为恐惧感。恐惧与冲突性紧张塑造了暴力情景,导致了球场暴力行为的发生。提出,应规范球员行为表现,防止球员暴力惯习的形成;加强球队球员间的沟通交流,修复断裂的互动仪式链条;注重裁判执裁能力建设,维持现场球队双方情感能量的平衡;营造有序的观赛环境,激发球迷潜在的道德情感。旨在为CBA健康有序发展提供建议与参考。     

NiCo_2O_4纳米结构阵列的水热合成与氧析出特性研究

钴酸镍纳米材料具有良好的电催化氧析出反应(Oxygen Evolution Reaction,OER)活性,是一种很有发展潜力的非贵金属电催化材料。文章以碳纤维纸为基底,采用水热合成的方法对纳米结构钴酸镍的生长进行了系统的研究,分别考察了生长温度、前驱体浓度和配比、生长时间对产物的形貌、尺寸、物相结构、OER电化学性能的影响,通过对比分析后发现在生长温度100℃、生长时间5h、镍钴比为2:1时所获得的多孔片状钴酸镍纳米结构具有最佳的OER特性。     

Concordance of apolipoprotein B concentration with the Friedewald,Martin-Hopkins,and Sampson formulas for calculating LDL cholesterol

IntroductionTwo new formulas, the Martin-Hopkins and the Sampson formula, were recently developed to overcome shortcomings of the Friedewald formula for calculating LDL-cholesterol. We aimed to compare the concordance of the two formulas with apolipoprotein B (apoB), a surrogate marker of the number of LDL particles.Materials and methodsIn a study of serum lipid data of 1179 patients who consulted the AZ St-Jan Hospital Bruges for cardiovascular risk assessment, the correlation and concordance of the Friedewald, Martin-Hopkins and Sampson formulas with apoB concentration, measured by immunonephelometry, were determined and compared.ResultsThe Martin-Hopkins formula showed significantly higher correlation coefficient than the Friedewald formula with apoB in the entire dataset and in patients with low LDL-cholesterol < 1.8 mmol/L. Both Martin-Hopkins and Sampson formulas yielded > 70% concordance of LDL-cholesterol with regard to treatment group classification based on population-equivalent thresholds of apoB in hypertriglyceridemic patients (2-4.5 mmol/L), with the highest concordance (75.6%) obtained using Martin-Hopkins formula vs. 60.5% with Friedewald formula.ConclusionThe Martin-Hopkins (and, to a lesser extent, Sampson) formula is more closely associated with the number of LDL particles than Friedewald formula. This, in combination with literature evidence of lesser accuracy of the Friedewald formula, is an argument to switch from Friedewald to a modified, improved formula.     

Evaluation of adverse drug reaction formatting in drug information mobile phone applications

Objective:To evaluate the differences in presentation (formatting) of adverse drug reaction (ADR) information within drug monographs in commonly used drug information (DI) mobile device applications.Methods:A cross-sectional analysis of ADR formatting of twenty commonly prescribed oral medications within seven DI mobile applications was performed. Databases were assessed for ADR information, including presence of placebo comparisons, severity of ADR, onset of ADR, formatting of ADRs in percentile (quantitative) format or qualitative format, whether references were used to cite information, and whether ADRs are grouped by organ system. Data was collected by two study investigators and discrepancies were resolved via consensus.Results:The seven DI mobile applications varied significantly on every analyzed ADR variable with the exception of ADR onset, which was absent in all databases. Significant differences were found for variables known to impact clinical judgment such as placebo comparisons and qualitative versus quantitative formatting. Placebo comparisons were most common among monographs in Lexicomp (30%) but were absent among monographs within other applications. Quantitative information was commonly used in most databases but was absent in Epocrates. Qualitative formatting was present in all Epocrates and Micromedex applications but absent in the majority of other applications. Substantial variations were also found in severity and grouping information.Conclusion:Substantial variation in ADR formatting exists among the most common DI mobile applications. These differences may translate into alternative interpretations of medical information and thus impact clinical judgment. Health care librarians and clinicians should consider ADR formatting when choosing between DI applications.     

企业创新链从构建到跃升的过程机理分析——资源编排视角下的典型案例分析

选取比亚迪汽车股份有限公司作为案例对象,从企业资源编排视角出发探究企业创新链从构建到跃升的过程机理。研究发现：适配市场需求、政策规划及服务创新所形成的市场发展导向在企业创新链构建及跃升过程中起指引性作用;企业各阶段通过资源编排积蓄的创新资源和通过关系联结所形成的社会资本为其创新链构建提供了资源和关系基础;差异化资源编排行动与关系联结的交互适配过程展示了企业资源和关系权力位置的迭代进阶过程,是创新链模式跃升的资源和关系基础;企业技术随着其资源和关系权力位置从边缘到中心地位的变化实现了跨越,且技术跨越是创新链从“线性反馈式”到“多方协作式”再到“开放融通式”跃升的内驱动力。本文利用资源编排理论拓展了企业创新链研究,依托资源交换的社会关系性和资源动态关联特征拓宽了企业创新链构建及跃升的解释边界,为构建创新链并实现创新链“适时”跃升提供了新的分析视角。     

A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge

Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with ‘catatonic depression’ and admitted to a residential mental health facility. She was referred to our hospital for further investigation 3 months later. Heteroanamnesis revealed that the symptoms had been evolving progressively over several months. Magnetic resonance imaging (MRI) of the brain showed diffuse symmetrical white matter lesions in both hemispheres. Routine laboratory tests including vitamin B12 and folic acid were normal except for a slight normocytic, normochromic anaemia. Over the next 6 weeks her symptoms deteriorated, and she became unresponsive to stimuli. A new MRI scan showed progression of the white matter lesions. The neurologist requested plasma homocysteine (Hcys) which was more than 8 times the upper limit of normal. Further testing revealed increased methylmalonic acid and the patient was diagnosed with adult-onset cobalamin C deficiency. This case illustrates that Hcys and/or methylmalonic acid should be determined in patients presenting with neuropsychiatric symptoms suggestive of vitamin B12 deficiency with a normal serum vitamin B12 to rule out a late-onset cobalamin C deficiency.     

基于FPGA技术的8B/10B信道编码设计

该文在分析8B/10B编码原理的基础上,设计了改进型8B/10B编码方案.该编码在完成高速数据信道编码功能的同时,可另外提供一路实时低速信道.基于FPGA技术采用查表法实现了改进型编解码电路,通过仿真验证了该编码方案的有效性,并在Spartan6系列FPGA中进行了综合测试.结果表明,此编解码方法占用的FPGA逻辑资源...