Effect of arogh—A polyherbal formulation on the marker enzymes in isoproterenol induced myocardial injury

To study the protective role of Arogh on isoproterenol induced myocardial damage in rats. The effect of Arogh pretreatment on isoproterenol induced myocardial damage was assessed by studying the levels of lipid peroxides and changes in the activity of marker enzymes such as creatine kinase, lactate dehydrogenase and transaminases in serum and heart tissue. In isoproterenol administered rats, a significant decrease was observed in the activity of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide levels increased significantly in the serum and heart. In rats pretreated with arogh, the level of lipid peroxides and the activity of marker enzymes were maintained at near normal values. Pretreatment with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme patterm and histopathological studies of heart tissue.     

早期运动疗法对脑梗死偏瘫患者康复效果的观察

目的：探讨早期运动对脑梗死偏瘫患者肢体功能及生活能力的影响。方法：选择脑梗死偏瘫患者167例,随机为观察组(85例)和对照组(82例),2组均常规进行神经内科药物治疗,观察组加以运动疗法,分别于治疗前及治疗后1个月和3个月测评患者肢体运动功能(FMA)和日常生活活动能力(MBI,采用Barthel指数)。结果：2组治疗...     

Streptomycin inhibits electrophysiological changes induced by stretching of chronically infarcted rat hearts

Objective

To investigate stretch-induced electrophysiological changes in chronically infarcted hearts and the effect of streptomycin (SM) on these changes in vivo.

Methods

Sixty Wistar rats were divided randomly into four groups: a control group (n=15), an SM group (n=15), a myocardial infarction (MI) group (n=15), and an MI+SM group (n=15). Chronic MI was obtained by ligating the left anterior descending branch (LAD) of rat hearts for eight weeks. The in vivo blockade of stretch-activated ion channels (SACs) was achieved by intramuscular injection of SM (180 mg/(kg·d)) for seven days after operation. The hearts were stretched for 5 s by occlusion of the aortic arch. Suction electrodes were placed on the anterior wall of left ventricle to record the monophasic action potential (MAP). The effect of stretching was examined by assessing the 90% monophasic action potential duration (MAPD₉₀), premature ventricular beats (PVBs), and ventricular tachycardia (VT).

Results

The MAPD₉₀ decreased during stretching in both the control (from (50.27±5.61) ms to (46.27±4.51) ms, P<0.05) and MI groups (from (65.47±6.38) ms to (57.47±5.76 ms), P<0.01). SM inhibited the decrease in MAPD₉₀ during inflation ((46.27±4.51) ms vs. (49.53±3.52) ms, P<0.05 in normal hearts; (57.47±5.76) ms vs. (61.87±5.33) ms, P<0.05 in MI hearts). The occurrence of PVBs and VT in the MI group increased compared with that in the control group (PVB: 7.93±1.66 vs. 1.80±0.86, P<0.01; VT: 7 vs. 1, P<0.05). SM decreased the occurrence of PVBs in both normal and MI hearts (0.93±0.59 vs. 1.80±0.86 in normal hearts, P<0.05; 5.40±1.18 vs. 7.93±1.66 in MI hearts, P<0.01).

Conclusions

Stretch-induced MAPD₉₀ changes and arrhythmias were observed in chronically infarcted myocardium. The use of SM in vivo decreased the incidence of PVBs but not of VT. This suggests that SACs may be involved in mechanoelectric feedback (MEF), but that there might be other mechanisms involved in causing VT in chronic MI.     

Study of C-Reactive Protein and Myocardial Infarction in the Indian Population

To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32 patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event.     

An m-health application for cerebral stroke detection and monitoring using cloud services

Over 25 million people suffered from cerebral strokes in a span of 23 years. Many systems are being developed to monitor and improve the life of patients that suffer from different diseases. However, solutions for cerebral strokes are hard to find. Moreover, due to their widespread utilization, smartphones have presented themselves as the most appropriate devices for many e-health systems. In this paper, we propose a cerebral stroke detection solution that employs the cloud to store and analyze data in order to provide statistics to public institutions. Moreover, the prototype of the application is presented. The three most important symptoms of cerebral strokes were considered to develop the tasks that are conducted. Thus, the first task detects smiles, the second task employs voice recognition to determine if a sentence is repeated correctly and, the third task determines if the arms can be raised. Several tests were performed in order to verify the application. Results show its ability to determine whether users have the symptoms of cerebral stroke or not.     

触发脑梗死危险因素的Logistic回归分析

目的：探讨与脑梗死急性发作有关的触发危险因素，为有效防治突发脑梗死提供依据。方法：采用病例对照研究方法对研究对象进行调查，应用非条件Logistic回归模型完成单因素及多因素分析。结果：多因素非条件Logistic逐步回归显示近期感染OR=7．52，TIA的OR=2．11，情绪波动OR=1．59和预防性治疗OR=0．15与脑梗死猝发有关联，其差别有统计学意义（P〈0.05）。结论：近期感染、TIA、情绪波动是触发脑梗死的独立危险因素，而预防性治疗则是保护因素之一。     

LONG-TERM INHIBITION OF Na~ /H~ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅＮａ /Ｈ ｅｘｃｈａｎｇｅｒ (ＮＨＥ)ｉｓａｐＨ ｒｅｇｕｌａｔｏｒｙｐｒｏｔｅｉｎｐｒｅｓｅｎｔｉｎｔｈｅｐｌａｓｍａｍｅｍ ｂｒａｎｃｅｏｆｃａｒｄｉｏｍｙｏｃｙｔｅｓａｎｄｏｔｈｅｒｃｅｌｌｔｙｐｅｓ.ＡｌｔｈｏｕｇｈｓｅｖｅｒａｌｉｓｏｆｏｒｍｓｏｆＮＨＥｈａｖｅｂｅｅｎｄｅ ｃｒｉｂｅｄ,ｔｈｅｐｒｅｄｏｍｉｎａｎｔｉｓｏｆｏｒｍｉｎｔｈｅｈｅａｒｔｉｓｔｈｅｕｂｉｑｕｉｔｏｕｓＮＨＥ 1 ,ｗｈｉｃｈｕｎｄｅｒｃｅｎｔａｉｎｐｈｙｓｉｏｌｏｇｉｃａｌｃｏｎｄｉｔｉ…     

血塞通加尼莫地平治疗血栓性梗塞的疗效观察

目的:观察血塞通加尼莫地平治疗血栓性脑梗塞的疗效。方法:52例血栓性脑梗塞患者随机分为血塞通组和丹参组血塞通组28例,在病因治疗和常规治疗基础上,加用血塞通注射液500mg静滴,每日一次(加5％G．S或0．9N．S)及口服尼莫地平20mg每日三次。丹参组24例,病因治疗及常规治疗其础上加丹参20ml静滴每日一次(加5％G．S或0．9％N．S)。观察入选病例4周后临床症状变化及头颅CT改变。结果:血塞通组总有效率79％,丹参纽总有效率49．7％。结论:血塞通加尼莫地平可明显改善血栓性脑梗塞的症状。     

脂蛋白(a)与脑梗塞的关系

目的研究脑梗塞患者血浆脂蛋白(a)水平.方法以酶联免疫吸附法(ELISA)测定44例脑梗塞患者与38名健康人血浆脂蛋白(a)浓度.结果脑梗塞患者的脂蛋白(a)浓度显著高于正常健康人.结论血浆高脂蛋白(a)水平是脑梗塞的重要危险因素.     

藻酸双脂钠对急性脑梗死患者纤维蛋白原、脂蛋白(a)的影响及疗效观察

目的：探讨藻酸双脂钠（PSS）治疗急性脑梗死患者血液成分变化及疗效。方法：急性脑梗死患者158例，随机分为两组。对照组：78例，常规治疗；治疗组：80例，在常规治疗基础上，应用藻酸双脂钠注射液100mg加入0．9％氯化钠静脉滴注，每日一次，连续观察14d。对比分析二组治疗前后脂蛋白（a）、血脂、纤维蛋白原等血液流变学指标．并动态观察治疗前后临床神经功能缺损评分。结果：藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL，与治疗前比较有显著性改变（P〈0．01或P〈0．05）；与对照组比较有显著性差异（P〈0．01或P〈0．05）．但对脂蛋白（a）无影响；近期预后较常规治疗组好（P〈0．05）．结论：藻酸双脂钠可改善血液高粘滞状态，起到降低纤维蛋白原、抗血小板聚集作用，可改善近期临床神经功能缺损程度。