Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population

Platelet-endothelial cell adhesion molecule-1 (PECAM-1) has role in atherosclerotic plaque development as well as in thrombosis leading to myocardial infarction (MI). Present study was aimed to analyse the association of PECAM-1 Leu125Val gene polymorphism with MI in Indian population. Subjects included healthy individuals as control (N = 116) and MI patients (N = 100) divided into two groups; MI patients at presentation of the acute event (MI-Group-1, N = 46) and patients with recent event of MI stabilized with treatment 4.5 days from their symptoms (MI-Group-2, N = 54). The difference in the distribution of Leu125Val genotype frequencies of controls and patients did not reach statistical significance. However Leu allele frequency (0.57) was more associated with MI patients as compared to control (0.504). sPECAM-1 levels were significantly elevated in patients at acute event of MI (MI-Group-1) by 44.1% (P = 0.009) as compared to controls and by 95.2% (P = 0.001) as compared to stabilized MI patients (MI-Group-2).     

脑卒中发病率与环境因素的影响研究

为了研究脑中风发病率与环境因素的关系,文章通过对原始数据进行的统计、预处理,用EXCEL做出各环境因素指标跟发病人数关系的散点图,统计回归建立了脑中风发病率与环境因素（气温、气压和相对湿度）影响的回归模型。     

左侧丘脑梗死24例临床分析

目的：探讨左侧丘脑不同动脉供血区梗死的临床表现。方法：根据临床和解剖学的关系进行研究。结果：左侧丘脑膝状体动脉供血区梗死以右侧偏侧型感觉障碍为主;左侧丘脑结节动脉供血区梗死多表现为丘脑性失语和神经精神障碍;左侧丘脑旁正中动脉供血区梗死表现为意识障碍、凝视麻痹等;左侧脉络膜后动脉供血区梗死主要表现为象限盲。结论：左侧丘脑不同动脉供血区梗死可导致各具特征的临床综合症。     

Integration of children with specific language impairments

Abstract

Current knowledge of the integration of children with specific language impairment (SLI) is examined. The paper begins by defining this group of children and the nature of their difficulties. The heterogeneous characteristics of SLI children are discussed. It then addresses the educational provisions made for SLI children and the opportunities for integration present in different models of provision. Research on the integration of SLI children is evaluated with particular emphasis on the difficulties encountered by this group of children. The paper concludes with some thoughts for future research.     

心肌梗塞患者康复早期适宜运动强度探讨

急性期后心肌梗塞病人(PMIP)进行适宜运动有利于机能的恢复及降低疾病复发率。通过对101名男性PMIP渐增负荷实验,测定和评价心脏康复早期的PMIP运动中的生理反应,为制定PMIP康复期运动处方提供适宜运动强度。结果表明:(1)PMIP应通过改变生活方式特别是改变饮食结构及参加体育运动来降低其BC的浓度;(2)康复初期的PMIP运动强度可被允许达到themodifiedBrucetreadmillprotocol的第三级或RPE13;(3)这一建议强度适用于大多数PMIP,有较广泛的使用价值。     

对肥胖青少年血压及脑血流动力学变化的研究

通过对18名单纯性肥胖青少年及18名同质非肥胖青少年血压、经颅多普勒脑血流动力学指标进行检测 和对比,结果表明:肥胖青少年的血压明显高于正常体重者;脑血流动力学指标下降,但其脑血管弹性仍然正常。     

Polymorphisms in the genes for coagulation factor II,V, VII in patients undergoing coronary angiography

Objective: To determine whether polymorphisms in the genes for coagulation factor. II, V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation factor II(G20210A), V(G1691A), VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay. Results: The R353Q and HVR4 gemotype of the factor VII distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ+QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history (P<0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII (G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor II(G20210A), V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353 Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese. Project (No. 021103166) supported by a grant from the Key Project of Science and Technology Commission of Zhejiang Province, China     

Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart

Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=17). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P<0.05)]. Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group     

Effect of antihypertensive drugs on cardiac enzymes in hypertension with myocardial infarction in NIDDM

Enzymology is a diagnostic indicator for myocardial infarction and diabetes in hypertension patients. Therefore the selection of methods for measurement of cardiac enzyme, Aspartate transaminase (AST), Creatine kinase(CK), and isoenzyme of creatine kinase (MB form), determine the effectiveness of antihypertension drug would provide the physician with diagnostic and prognostic clinical evidence.