Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model

Background and Objectives  

Chronic kidney disease (CKD) is a growing public health problem with an urgent need for new pharmacological agents. Cordyceps cicadae is widely used in traditional Chinese medicine (TCM) and has potential renoprotective benefits. The current study aimed to determine any scientific evidence to support its clinical use.     

Effect of tadalafil in chronic renal failure rabbits: relevance to erectile dysfunction

It is of great importance to investigate an effective and reliable medication against chronic renal failure (CRF)-related erectile dysfunction (ED), which aims to improve patients’ life qualities. The concentrations of cyclic guanosine monophosphate (cGMP) in the corpus cavernosal smooth muscle of both CRF and control rabbits were measured. The effects of various concentrations of tadalafil, papaverine, and sodium nitroprusside on the relaxation responses of corpus cavernosal smooth muscle pre-contracted with phenylephrine in CRF rabbits were observed. There was significant difference in the concentration of cGMP between CRF and control rabbits (P<0.01). Tadalafil had the greatest impacts on CRF rabbits when given the same concentration of papaverine or sodium nitroprusside and particularly significant differences were identified under the concentration levels of 10⁻⁵ and 10⁻⁴ mol/L (P<0.01). The results suggest that the cGMP concentrations of the corpus cavernosum had been greatly reduced in CRF rabbits compared with control rabbits and that tadalafil may be an ideal medication for use in the treatment of CRF-related ED.     

氨溴索治疗慢性支气管炎急性发作的疗效分析

目的：探讨氨溴索治疗慢性支气管炎急性发作的临床疗效及不良反应.方法：选取慢性支气管炎急性发作患者92例,随机分为对照组44例和观察组48例.对照组患者给予抗感染、祛痰、镇咳、平喘等常规治疗,观察组在对照组基础上加用盐酸氨溴索葡萄糖注射液滴注.结果：观察组临床控制率和总有效率均明显高于对照组（P＜0.05）,观察组平均住院天数明显少于对照组（P＜0.05）,两组均未出现明显不良反应.结论：氨溴索治疗慢性支气管炎急性发作临床疗效佳,且用药安全,可推广应用.     

慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的舒适护理效果观察研究

目的:探讨慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的临床护理方法及其疗效。方法:随机选择2012年1月~2014年2月广西中医药大学第一附属医院收治的100例慢性阻塞性肺疾病合并呼吸衰竭使用无创呼吸机进行治疗的患者,将所有患者随机分为研究组与对照组,每组50例患者。研究组患者给予舒适护理治疗,对照组患者给予常规护理治疗,分析两组的最终护理效果。结果:研究组患者在治疗积极配合率、并发症发生率以及不良情绪发生率上明显优于对照组,研究组患者的PaO2、PH与对照组对比,都明显高于对照组,PaCO2明显低于对照组,两组对比差异有统计学意义(P0.05)。结论:对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机患者给予舒适护理治疗,可有效改善症状,提高临床疗效,值得推广。     

慢性乙型肝炎中医药治疗进展

慢性乙型肝炎（chronic hepatitis B,CHB）是临床的常见病、多发病,中医药在治疗慢性乙型肝炎有着丰富的临床经验。文章通过近几年来中医药在诊治慢性乙型肝炎的有关著作与文献资料的分析概括,阐述了慢性乙型肝炎的病因病机,辨证分型,专方专药治疗,总结了中医药的临床治疗近况。     

谁的意志 谁的利益——传统法视野下法律统治阶级意志论新辨

传统中国君主专制的政治形态下,君主权力几近不受约束,立法者尤其是最高立法者个人之偏见、情感、私利可毫无阻碍地作用于立法活动,法律背离统治阶级整体意志,遂成寻常之事。传统中国法律经常背离统治阶级意志的历史事实说明,法律反映统治阶级意志这一马克思主义法学基本命题,具有实然与应然双重意义,近代以前其意义多为应然,近代以后随着民主政治的建立、完善,其意义则由应然逐渐转为实然。近代民主政治的建立,是法律反映统治阶级意志成为实然之根本前提。     

Current status of percutaneous coronary intervention of chronic total occlusion

This paper describes the current status of percutaneous coronary intervention (PCI) for totally occluded coronary arteries. Chronic total occlusion is associated with 10%–20% of all PCI procedures. Results show that opening an occluded vessel, especially one supplying a considerable area of myocardium, may be beneficial for a patient’s angina relief and heart function. We describe the devices used currently in re-canalization such as new wires, microcatheters (including Tonus and Cosair) and intravascular ultrasound guidance. Different techniques to improve the success rate and reduce complications are discussed in detail.     

Communicating About Chronic Caregiving in the Workplace: Employees’ Disclosure Preferences,Intentions, and Behaviors

A growing number of Americans are living with chronic health conditions that require informal, ongoing care from family members who are also in the paid labor force. In this exploratory study, communication privacy management is used to make sense of chronic caregiving (N = 48–64) and noncaregiving (N = 174–178) employees’ disclosure preferences, intentions, and behaviors in the workplace. We find that workers in general anticipate that they would disclose to many individuals at work about their caregiving, but employees actually disclose much less information to far fewer people at work when they occupy the chronic caregiver role. For chronic caregivers, positive perceptions about coworker supportiveness predict increased disclosure behaviors. Finally, future research directions as employers, workers, and policy makers prepare for the complex challenges associated with negotiating paid work and unpaid chronic caregiving are provided.     

双环醇治疗慢性乙型病毒性肝炎肝纤维化及其作用机制

[目的]观察双环醇对慢性乙型病毒性肝炎患者肝纤维化程度以及肝组织内转化生长因子β1(TGF-β1)和Ⅰ、Ⅲ型胶原含量的影响.[方法]20例慢性乙型病毒性肝炎患者以双环醇75~150 mg/d治疗24周,治疗前后分别肝活检进行常规病理学检查,并应用免疫组化技术和多媒体彩色病理图文分析系统观察双环醇治疗前后肝组织内TGF-β1和Ⅰ、Ⅲ型胶原含量的变化.[结果]慢性乙型病毒性肝炎肝纤维化患者经双环醇治疗后,肝组织炎症和纤维化程度明显改善,肝组织内TGF-β1和Ⅰ、Ⅲ型胶原含量均较治疗前明显降低,差异有显著性(P<0.05).[结论]双环醇治疗可以减轻慢性乙型病毒性肝炎患者肝脏炎症反应,同时明显降低慢性乙型病毒性肝炎患者肝组织内TGF-β1和Ⅰ、Ⅲ型胶原的含量,从而发挥抗纤维化作用.