卓越之道:学科交叉与群体智慧——"哈佛催化剂"个案研究及启示

转化医学研究与实践为学科交叉渗透、群体智慧聚集提供了理想的平台和机遇。通过详细分析哈佛催化剂的产生背景、运作模式、研究内容以及人才水平,提示国内一批重点高校在向世界一流大学迈进的过程中,转化医学是一个非常值得重视的研究领域。促使科研选题来源于临床、完善相关体制、保证跨学科研究团队的稳定性是促进我国转化医学研究的有效途径。     

案例教学法在《预防医学》教学中的应用

通过收集和编写与预防医学教材内容相配套的教学案例及制作多媒体课件,推行＂以案例为中心,培养临床医学专业学生公共卫生思维＂的教学实践,强化了临床医学专业的学生＂预防为主＂和＂三级预防＂的思想,提高了学生综合分析及判断能力,取得了较好的教学效果.     

Internalizing symptoms and polyvictimization in a clinical sample of adolescents: The roles of social support and non-productive coping strategies

Given the high prevalence of internalizing disorders during adolescence, it is necessary to determine the factors influencing their development and evolution. The aim of this study was to evaluate the role of polyvictimization in developing internalizing symptoms while considering the possible effect of non-productive coping and the availability of social support. The participants were 144 adolescents (M = 14.31, SD = 1.48) cared for in child and adolescent mental health services. The results of multiple regression analysis indicated that polyvictimization, non-productive coping and social support were good predictors of internalizing symptoms. In addition, non-productive coping acted as a mediator in the relationship between polyvictimization and internalizing symptoms. The results of the study emphasized the importance of the studied factors to understanding the process of development internalizing symptoms and to preventing or treating adolescents who suffer from these types of disorders.     

应用Protégé构建临床药物本体的探索*

通过对临床药物领域大量概念的分析，提出若干类和属性，并以这些类和属性初步构建成包含4种临床药物的试验性临床药物学本体，由此了解药物本体的构建特点，为药学本体具体应用完善专家系统，指导临床医生用药提供必要的决策支持。     

蛋白质组学研究进展及展望

蛋白质组从蛋白质整体水平上研究其作用模式、功能机理、调节调控以及蛋白质组群内的相互作用，从而为临床诊断、病理研究、药物筛选、新药开发、新陈代谢途径研究等提供理论依据和基础。蛋白质组的研究手段主要有2DE、质谱技术以及研究蛋白质之间相互作用的酵母双杂交、表面等离子技术等。本简单地回顾了近年来蛋白质组学研究的一些成果及该领域近年来的发展动态。     

后基因组时代的蛋白质组学

蛋白质组学研究是近年来兴起的生命科学的前沿领域,是生命科学进入后基因组时代的标志之一.简要介绍了蛋白质组和蛋白质组学的概念、产生背景,阐述了蛋白质组学的研究内容、方法和研究意义,并展望了其发展前景.     

蛋白质组学及其在植物胚胎发育研究上的应用

蛋白质组学被认为是后基因组研究中的最主要的部分;介绍蛋白质组学主要相关技术;探讨蛋白质组学尤其是差异蛋白质组学的研究意义与特点;简要介绍该技术在植物胚胎发育研究上近期研究概况。     

Effective factors on accuracy of principal diagnosis coding based on International Classification of Diseases,the 10th revision (ICD-10)

Quality of diagnostic data depends on accurate coding. The purpose of this study was to assess the accuracy of principal diagnosis coding and its effective factors. To achieve this aim, three hundred and seventy medical records were randomly selected and recoded blindly (as gold standard). The effects of possible factors on accuracy of coding which was gathered through observation method were analyzed by Chi-square (χ²), Fisher exact test, odds ratio (OR), and confidence interval 95% for OR.     

差异蛋白质组学在运动人体科学中的应用展望

差异蛋白质组学是现阶段蛋白质组学研究的一个主要内容。它着重于寻找和筛选由任何有意义的因素引起的2个样本之间的差异蛋白质图谱,以揭示细胞生理和病理状态的进程和本质,细胞对外界环境刺激反应的途径,以及细胞调控机制,同时获得对某些关键蛋白质的定性和功能分析。它对于寻找有意义的生物标志物和确定信号转导通路具有重要的实际意义。本文阐述了差异蛋白质组学的概念、研究内容、研究技术及其研究进展,并着重论述了其在运动人体科学专业研究中的应用前景。     

Gray cases of child abuse: Investigating factors associated with uncertainty

Research in child abuse pediatrics has advanced clinicians’ abilities to discriminate abusive from accidental injuries. Less attention, however, has been paid to cases with uncertain diagnoses. These uncertain cases – the “gray” cases between decisions of abuse and not abuse – represent a meaningful challenge in the practice of child abuse pediatricians. In this study, we describe a series of gray cases, representing 17% of 134 consecutive children who were hospitalized at a single pediatric hospital and referred to a child abuse pediatrician for concerns of possible abuse. Gray cases were defined by scores of 3, 4, or 5 on a 7-point clinical judgment scale of the likelihood of abuse. We evaluated details of the case presentation, including incident history, patient medical and developmental histories, family social histories, medical studies, and injuries from the medical record and sought to identify unique and shared characteristics compared with abuse and accidental cases. Overall, the gray cases had incident histories that were ambiguous, medical and social histories that were more similar to abuse cases, and injuries that were similar to accidental injuries. Thus, the lack of clarity in these cases was not attributable to any single element of the incident, history, or injury. Gray cases represent a clinical challenge in child abuse pediatrics and deserve continued attention in research.