Fibonacci数的行列式表示

利用行列式的降阶定理,构造出n阶自相似方阵序列f_n(n=1,2,…),使得其行列式的值|f_1|,|f_2|,|f_3|,|f_4|…,|f_n|,…对应着Fibonacci数1,2,3,5,…,F_n,…     

An in vitro model mimicking the complement system to favor directed phagocytosis of unwanted cells

BackgroundOpsonization, is the molecular mechanism by which target molecules promote interactions with phagocyte cell surface receptors to remove unwanted cells by induced phagocytosis. We designed an in vitro system to demonstrate that this procedure could be driven to eliminate adipocytes, using peptides mimicking regions of the complement protein C3b to promote opsonization and enhance phagocytosis. Two cell lines were used: (1) THP-1 monocytes differentiated to macrophages, expressing the C3b opsonin receptor CR1 in charge of the removal of unwanted coated complexes; (2) 3T3-L1 fibroblasts differentiated to adipocytes, expressing AQP7, to evaluate the potential of peptides to stimulate opsonization. (3) A co-culture of the two cell lines to demonstrate that phagocytosis could be driven to cell withdrawal with high efficiency and specificity.ResultsAn array of peptides were designed and chemically synthesized p3691 and p3931 joined bound to the CR1 receptor activating phagocytosis (p < 0.033) while p3727 joined the AQP7 protein (p < 0.001) suggesting that opsonization of adipocytes could occur. In the co-culture system p3980 and p3981 increased lipid uptake to 91.2% and 89.0%, respectively, as an indicator of potential adipocyte phagocytosis.ConclusionsThis in vitro model could help understand the receptor–ligand interaction in the withdrawal of unwanted macromolecules in vivo. The adipocyte-phagocytosis discussed may help to control obesity, since peptides of C3b stimulated the CR1 receptor, promoting opsonisation and phagocytosis of lipid-containing structures, and recognition of AQP7 in the differentiated adipocytes, favored the phagocytic activity of macrophages, robustly supported by the co-culture strategy.How to cite: Bartsch IM, Perelmuter K, Bollati-Fogolin M, et al. An in vitro model mimicking the complement system to favor directed phagocytosis of unwanted cells. Electron J Biotechnol 2021;49. https://doi.org/10.1016/j.ejbt.2020.09.010.     

相依为命——一种原型心理的探析

在比较文学的中国学派——“阐发研究”的框架下,运用西方的神话——原型批评的理论,对中国文学作品中“相依为命”的人物关系程式进行分析,探究其文化心理结构。中国文化的一个最有影响的原型就是阴阳互补观念,它是我们民族的一种原型心理,对中国文化的各方面都有深远的影响。“相依为命”程式就是这种原型心理的“复现”和“生成”。     

互补理论在高校教职工思想政治教育工作中的应用研究

互补理论为同一事物中的不同元素之间的相互支持,相互补充,共同促进的一种和谐关系。高校教职工思想政治教育工作发展过程中出现了很多制约因素。在互补理论的指导下通过统一领导与分类引导互补,思想政治教育与心理健康教育互补,解决思想问题与解决实际问题互补,服务大局与个人发展互补来推动高校思想政治教育工作纵深发展。     

略论现代汉语中情态补语的修辞功能

从语法和修辞相结合的角度,对情态补语的基本内容和结构进行了简单的介绍,并以此作为后面修辞功能研究的基础,着重分析情态补语的三个修辞功能。情态补语的陈述功能:情态补语是句子的重心,信息含量大,有一定的歧义性;情态补语的描绘功能:情态补语具有生动、形象、夸张的特点,且有强调作用;情态补语的评价功能:从述语、主语、宾语的角度进行分析。