拟静力试验桥墩的损伤评价

钢筋混凝土构件的抗震性能,包括强度、刚度、强度退化、刚度退化、延性、能量耗散、构件破坏等的变化规律。本文从地震作用下结构（构件）损伤评价出发,采用九个墩柱的破坏性试验数据,通过基于位移延性系数的损伤评价模型和经典损伤评价模型对试验墩柱的损伤程度进行了评价,并比较了两种评价方法的适用性。     

Three-step damage identification method based on dynamic characteristics

A three-step damage identification method based on dynamic characteristics is proposed to improve the structure reliability and security and avoid serious accident. In the proposed method, the frequency and difference of modal curvature （DMC） are used as damage indexes. Firstly, the detection of the occurrence of damage is addressed by the frequency or the square of frequency change. Then the damage location inside the structure is measured by the DMC. Finally, with the stiffness reduction rate as a damage factor, the amount of damage is estimated by the optimization algorithm. The three-step damage identification method has been validated by conducting the simulation on a cantilever beam and the shaking table test on a submerged bridge. The results show that the method proposed in this paper can effectively solve the damage identification problem in theory and engineering practice.     

Life extending control of helicopter based on dynamic inversion

The purpose of using life extending control for Black Hawk UH-60 helicopter is to make a trade-off between the handling qualities and the service life of critical components. An increase in service life span results in enhanced safety and the reduction in maintenance costs. This paper presents a design methodology of life extending control for structural durability and high performance of mechanical system, which is based on an explicit dynamic inversion control scheme. A real-time nonlinear fatigue crack growth model is built to predict fatigue damage resulting from the impact of cyclic bending stress on rotor shaft, which serves as an indicator of service life. The 4-axis gain- scheduled flight controller, whose gains are adjusted as a function of damage and flight velocity, is designed to regu- late roll attitude, pitch attitude, vertical velocity and yaw rate. The nonlinear system simulation results show that the responses can meet the requirements on ADS-33 Level 1 handling qualities and that the 4-axis decoupling control is realized. As the damage increases, the tracking performance is slightly degraded, which results in smaller transients in bending moment response.     

哺乳动物细胞线粒体基因组的转录及调控机制研究进展

目的：系统的归纳和总结近年来哺乳动物线粒体基因组转录及调控机制研究的进展,以期为哺乳动物和人类线粒体疾病及相关医学领域的研究提供参考依据。方法：从哺乳动物线粒体DNA（mtDNA）的结构和转录过程,转录基本元件和转录机制等方面,检索和整理近年来关于哺乳动物细胞线粒体基因组的转录及调控机制的文献并进行总结。结果：线粒体是哺乳动物细胞中普遍存在的具有独立基因组的半自主性细胞器,其主要功能是通过氧化磷酸化为细胞提供ATP,同时对于物质代谢、细胞周期调控、细胞分化和凋亡、细胞信号传递等生理过程发挥着重要作用。近年来对线粒体基因组的转录及其调控机制的研究已取得了一些突破和成果。结论：哺乳动物线粒体基因组的转录与调控机制的研究不仅有助于深入阐明和理解线粒体基因组的表达调控机制,而且也助于揭示临床线粒体病的发病机制。     

知识产权诉讼中侵权损害赔偿数额的确定——从完善程序法角度分析

国家为了加强对知识产权的保护,在北京、上海、广州设立了知识产权法院,这就需要在实体法和程序法两个层面对解决知识产权侵权以及相关问题进行科学设计和完整规划。我国的《著作权法》、《商标法》、《专利法》从实体法上完善了法院的裁判标准,但是在程序法上,尤其是在知识产权侵权诉讼中损害赔偿数额的确定方面,尚未形成针对其特殊性而设计的完整、有效的解决方案。而诉讼法理论运用的缺乏也导致司法实务中出现了很多问题,特别是诉讼证据制度亟待完善。     

双层桥箱内壁车辆碰撞混凝土损伤仿真研究

双层连续箱梁桥是一种新型结构体系,如何评价车辆撞击箱梁内部造成的结构损伤对于这种新型结构的广泛运用具有重要意义。通过计算机仿真技术研究各种工况下车辆对箱梁桥内壁撞击引起的结构损伤情况,得出混凝土损伤部位以及程度,分析影响混凝土损伤的敏感因子,为双层桥结构设计提供参考。     

论国家赔偿中精神损害赔偿的界定

2010年修正的《国家赔偿法》在实际的法律适用中面临着新的需求和挑战.现实的基本应用对国家赔偿特别是其中的精神损害赔偿提出了更为明确具体的指引需求.精神损害的适用范围、赔偿标准等问题都存在模糊之处,在法理和应用中都亟需进一步的探索和完善.     

Circulating Cell-Free DNA Level in Prediction of COVID-19 Severity and Mortality: Correlation of with Haematology and Serum Biochemical Parameters

Lymphocyte dysregulation in coronavirus disease-19 (COVID-19) is a major contributing factor linked to disease severity and mortality. Apoptosis results in the accumulation of cell-free DNA (cfDNA) in circulation. COVID-19 has a heterogeneous clinical course. The role of cfDNA levels was studied to assess the severity and outcome of COVID-19 patients and correlated with other laboratory parameters. The current case series included 100 patients with mild COVID-19 (MCOV-19) and 106 patients with severe COVID-19 (SCOV-19). Plasma cfDNA levels were quantified using SYBR green quantitative real-time PCR through amplification of the β-actin gene. CfDNA level was significantly higher in SCOV-19 at 706.7 ng/ml (522.6–1258) as compared to MCOV-19 at 219.8 ng/ml (167.7–299.6). The cfDNA levels were significantly higher in non-survivor than in survivors (p = 0.0001). CfDNA showed a significant correlation with NLR, ferritin, LDH, procalcitonin, and IL-6. The diagnostic sensitivity and specificity of cfDNA in the discrimination of SCOV-19 from MCOV-19 were 90.57% & 80%, respectively. CfDNA showed a sensitivity of 94.74% in the differentiation of non-survivors from survivors. CfDNA levels showed a significant positive correlation with other laboratory and inflammatory markers of COVID-19. CfDNA levels, NLR, and other parameters may be used to stratify and monitor COVID-19 patients and predict mortality. CfDNA may be used to predict COVID-19 severity with higher diagnostic sensitivity.     

浅析离婚损害赔偿制度的不足和完善

新《婚姻法》增设的离婚损害赔偿制度实施至今已有5年时间,但该制度的运行状况并不尽如人意,原因在于立法对该制度的规定过于疏漏,缺乏可操作性。针对该制度实施过程中凸现的几个问题的完善提出了粗浅意见。