Cancer vaccines: The new fight against cancer

The inability of the body’s immune system to differentiate cancer cells from normal cells allows cancer cells to proliferate in an uncontrolled manner. Newer strategies are being researched to overcome this immunological tolerance to cancer. Provoking the body’s immune system to generate vaccines against cancer is emerging as an important type of immunotherapy to treat cancers. These cancer vaccines, which have fewer side effects, and offer great promise. Many such vaccines have been identified and several of them are under clinical trials currently.     

荧光法研究3,5-二溴水杨醛缩4-溴苯胺铜配合物与DNA的作用机理

以溴化乙锭(EB)为荧光探针,运用荧光光谱、Scatchard图、热变性效应和盐效应等技术手段,研究了3,5-二溴水杨醛缩4-溴苯胺铜配合物与DNA的相互作用的机理.研究结果表明,配合物与DNA之间既有静电作用,又有部分的插入作用.     

Molecular modeling study of the effect of base methylation on internal interactions and motions in DNA and implication to B-Z conformation change

1. Introduction Experimental studies have shown that a DNA molecule with alternating pyrimidine-purine sequence can adopt a left-handed, double-helical Z-DNA conformation [1,2]. Such structural changes of DNA occur as a consequence of environmental conditions such as at salt concentration above 4 mol/L NaCl [1,2] or through certain chemical modification such as methylation [1] or bromination [2,3] of bases at physiological conditions. These structural changes and chemical modifications …     

外源DNA导入在小麦育种上的应用

近年来有计划的常规育种操作，使得目前小麦品种的遗传变异范围越来越窄，小麦育种的进一步发展需要利用和开拓丰富的基因资源。外源DNA导入为小麦育种提供了新的途径。本文综述了外源DNA导入的方法，分析了各种导入方法的优缺点。并对其在小麦育种中的应用进行了综述。     

诺氟沙星-钇配合物的合成及其与DNA作用的研究

文章合成了新的诺氟沙星-钇配合物,并应用荧光、黏度和热变性等方法,对此化合物与小牛胸腺DNA作用方式进行了研究.结果表明:配合物与DNA作用时,荧光发生淬灭,黏度增大,热变性温度升高;Scatchard图表明配合物对溴化乙锭(EB)与DNA的结合为竞争性抑制;配合物与DNA作用方式为嵌插结合.     

由一道易错的有丝分裂题目引发的讨论

讨论法使生物课堂教学既有由教师到学生的信息传输,叉有由学生到教师的信息反馈,还有学生与学生之间的信息交流。教师也能从学生身上吸取丰富的养料从而不断自我更新．届时教学相长将不再是一句空话。     

DNA storage: research landscape and future prospects

The global demand for data storage is currently outpacing the world''s storage capabilities. DNA, the carrier of natural genetic information, offers a stable, resource- and energy-efficient and sustainable data storage solution. In this review, we summarize the fundamental theory, research history, and technical challenges of DNA storage. From a quantitative perspective, we evaluate the prospect of DNA, and organic polymers in general, as a novel class of data storage medium.     

分子标记的发展及应用

随着分子生物学的迅速发展，DNA分子标记越来越受到重视。本文介绍了分子标记的发展，论述了DNA分子标记在基因组作图、基因克隆、物种亲缘关系分析及疾病诊断等方面的应用。     

国家安全视阈的疫苗产业竞争情报研究

[研究目的]疫苗产业的国际竞争已跃升为大国之间的正面对抗领域。国家安全视阈的疫苗产业竞争情报研究,使竞争情报的服务对象提升到了国家安全高度,具有典型的理论研究价值和实践应用价值。[研究方法]该文首先分析了疫苗产业对国家安全的影响路径;进而从情报理论探析和情报实践探索两个层面入手,基于国家安全视阈阐述了对疫苗产业竞争情报工作的思考。[研究结论]疫苗产业竞争情报工作的各相关主体应着眼国家安全大局,综合关注产业链内外部条件,明确情报规划目标,高效获取和分析相关信息,提升相关情报产品与服务的水平。     

Changes in antioxidant enzyme levels and DNA damage during aging

Multiple mechanisms underlie the human aging process, but interest continues in the role that free radicals and antioxidants may play. The concentrations of lymphocyte free radical generation (O₂ ⁻& H₂O₂), DNA damage and antioxidant enzyme levels (glutathione Stransferase, superoxide dismutase and catalase) were evaluated in 110 healthy individuals with an age range of 20–80 years. The antioxidant enzyme levels were significantly less in very old age when compared to young. Moreover, the levels of free radical concentration and DNA damage were increased in the same age group with respect to younger group. Cigarette smoking had a positive relation with free radicals and DNA damage, and inverse relation with antioxidants. On the other hand, body mass was found to have positive relation with free radical generation only. The data indicate that depletion of antioxidant enzyme levels would render the older people more susceptible to free radical stress and DNA damage.