肥胖与运动研究进展——慢性炎症反应学说

对解释肥胖的新学说-慢性炎症反应学说进行了简单的介绍,并分析了几种重要的炎症反应标志物(如白细胞介素6、肿瘤坏死因子α等)在机体组织内合成与分泌的规律,同时还简单介绍了慢性炎症反应导致肥胖的可能机制:低氧及对应激的自我保护.另外,运动对肥胖的治疗具有积极作用,简单阐述了运动缓解肥胖的机制:抗炎症反应.     

从第九届世界健美操锦标赛看六人项目的发展趋势

采用文献资料法和综合分析法对第九届世界锦标赛竞技健美操六人项目的情况进行分析,并得出六人项目发展趋势是：更加注重艺术性创新、动作技术的完成将更加完美、难度动作向多样化发展。     

IPv6在下一代互联网中的应用技术探析

随着世界各国信息高速公路计划的实施,现在Internet正以令人难以置信的速度发展,但是由于技术上的某些原因,Internet的发展受到了一定限制。下一代互联网Internet2的实验计划应用而生,IPv6是其基础和灵魂。作为新一代的网络协议,它成功地解决了现在IP地址不足、网速过慢、安全无保障等一直困扰着我们的难题。我国在IPv6研究上也处于世界先进水平。相信下一代互联网会使人们的生活方式发生根本的改变。     

"六城会"反兴奋剂工作探析

阐述了我国反兴奋剂工作的概况,分析了"六城会"反兴奋剂工作面临的挑战,在此基础上提出了"六城会"反兴奋剂工作的几点建议.     

运动与IL-6的研究进展

通过文献资料调研，总结并分析以往至最新的IL-6研究成果，从运动与肌源性IL-6、运动与不同类型肌纤维IL-6的生成、运动训练与IL-6及IL-6R系统、运动模式与IL-6、糖代谢与IL-6、IL-6与抗氧化剂VC、VE、IL-6与IL-8、IL-6与SOCS-3几个方面论述运动介导下，IL-6的生成特点、影响因素和生物学功能。     

EViews6软件的逐步回归分析模块在多重共线性教学中的应用

计量经济学传统教学中对逐步回归法的讲解都是基于EViews软件的较低版本而展开的，这种处理方式虽有助于学生理解逐步回归法的原理，但是回归与检验的多次交替会浪费课堂教学时间，不利于提高教学效率。然而，如果采用含有逐步回归分析模块的EViews6软件来开展多重共线性的教学，变量的筛选工作由软件自动完成，能节省不必要的操作，在不影响教学效果的同时提高教学效率。     

Y对挤压Mg-6Gd-xY合金组织及性能的影响

本文研究了钇对挤压Mg-6Gd-xY合金的显微组织、时效析出以及常温拉伸性能的影响。结果表明,添加稀土元素Y之后,合金的挤压态组织得到细化,但时效态组织细化不明显,时效后形成镁的稀土相Mg(Gd,Y)的强化相,使抗拉强度提高34~81MPa;合金的显微硬度随Y含量增加提高20HV,时效峰值的出现时间因Y的添加提前35h。     

CRP,but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Objective

The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.

Methods

The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m². Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m².

Results

In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.

Conclusion

The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

     

多媒体通信网络边缘实施策略研究

多媒体通信网络具有连接通信主机、数位设备多和业务种类多等特点。因为IPv4地址面临枯竭,IPv6地址使用迫在眉捷。利用现有IPv4网络为承载网络,在边缘网络实现IPv6化,是当前解决IPv4地址严重不足的一种解决方法。为了实现IPv4与IPv6的业务服务兼容,可以6to4和区分服务来解决两类地址转换引起的服务质量问题。     

A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats

Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with ¹²⁵I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics, and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t _{1/2K a}) and 19.77–21.53 h (elimination, t _1/2Ke), and peak concentrations at 20.51–21.96 h (t _peak) in rats. Half-lives and t _peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192 h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.