一种3G手机网络游戏服务器架构的分层设计

3G手机网络游戏互动娱乐应用平台基于3G无线网络的高带宽及封装的底层协议、高性能服务器端、跨平台客户端等技术,以实现业内最有挑战性的MMORPG游戏类型为目标.该系统建成能有效提高数据通讯传输速率、保障数据安全、确保达成即时互动和保障用户体验.     

云南松松塔抗HIV-1活性提取物急性毒性实验研究

目的：研究云南松松塔抗HIV-1活性提取物的急性毒性,对其用药安全性进行初步评价。方法：急性毒性实验采用最大给药量法,松塔提取物一次灌胃给药25 g/kg,观察小鼠在14 d内毒性表现,14 d后测量小鼠体重,脏器质量并对肝脏和肾脏作病理组织学检查。结果：急性毒性实验未见明显毒性。空白组与给药组各脏器指数差异无统计学意义,病理检查结果各组均未见异常。结论：本次实验结果显示,松塔活性提取物未见急性毒性反应。     

A latecomer's strategy to promote a technology standard: The case of Datang and TD-SCDMA

This paper studied the key strategies used by Datang, a local Chinese firm, to promote TD-SCDMA in order to explore an under-researched topic: how could a latecomer promote a technology standard? The findings suggest that Datang faced formidable challenges because of latecomer disadvantage and transitional institutions. The development of innovation capabilities and new technologies is needed but far from sufficient. It is necessary to develop special capabilities to get support from the government and public stakeholders such as scholars. The experience of Datang offers new insights into the development and adoption of technology standards sponsored by latecomers in developing countries.     

Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study

Dietary and lifestyle factors have been shown to have a profound effect on paraoxonase-1 (PON1) activity. Cigarette smoke has been shown to inhibit its mass and activity where as resveratrol has been shown to enhance it. We exposed hepatoma derived cell line (HepG2) to resveratrol and nicotine in varying doses and measured PON1 enzymatic activity and PON1 gene expression. In addition, total protein content of HepG2 cells was also measured. Resveratrol in a dose of 15 μmol/l or above significantly increased the PON1 enzyme activity (p > 0.001) where as nicotine in a dose of 1 μmol/l or higher significantly reduced it (p < 0.05). The resveratrol in this dose also enhanced the PON1 gene expression whereas nicotine decreased it as compared to controls. However, the protein conent of cells was not changed suggesting that they were not cytotoxic in the doses used. Till date the antioxidant vitamins have shown disappointing results against LDL oxidation and cardiovascular protection. However, the effect of resveratrol on PON1 gene expression and activity was significant, suggesting increase in PON1 activity and enhanced gene expression may be its alternative mechanism for offering protection against cardiovascular disease and may be an potential pharmacological agent which can be used for this.     

1999-2008年G20国家自然资本利用的空间格局变化

各国自然资本利用的时空分异评价是近期可持续发展领域的研究热点。本文采用改进的三维生态足迹模型,对1999-2008年20国集团(G20)自然资本利用的空间格局变化进行了分析。结果表明:G20国家的自然资本利用格局具有显著的空间分异性,呈现流量自然资本占用西高东低、存量自然资本消耗北高南低的格局。根据1999-2008年自然资本利用的变化趋势,可将G20国家分为4类:流量和存量自然资本利用增强型(FI-SI型,2国)、流量和存量自然资本利用减弱型(FD-SD型,2国)、流量自然资本利用增强而存量自然资本利用减弱型(FI-SD型,4国)、流量自然资本利用减弱而存量自然资本利用增强型(FD-SI型,11国)。总体上,流量自然资本占用减弱、存量自然资本消耗增强已成为各国自然资本利用的主要变化趋势,可持续性趋于劣化,代内和代际不公平程度加剧。     

Paraoxonase 1 activity and phenotype distribution in premenopausal and postmenopausal women

Introduction

Postmenopausal women have higher risk of cardiovascular disease. One of the contributing factors could be reduced activity of anti-atherogenic enzyme paraoxonase 1 (PON1). The aim of this study was to examine differences in the lipid status, paraoxonase and arylesterase PON1 activities and PON1 phenotype in women with regular menstrual cycle and in postmenopausal women.

Materials and methods:

The study included 51 women in reproductive age (25 in follicular and 26 in luteal phase of the menstrual cycle) and 23 women in postmenopause. Lipid parameters in sera were determined using original reagents and according to manufacturer protocol. PON1 activity in serum was assessed by spectrophotometric method with substrates: paraoxon and phenylacetate. PON1 phenotype was determined by double substrate method.

Results:

Compared to the women in follicular and luteal phase, postmenopausal women have significantly higher concentration of triglyceride [0.9 (0.7–1.3), 0.7 (0.6–1.0) vs. 1.5 (0.9–1.7) mmol/L; P = 0.002], cholesterol [5.10 (4.78–6.10), 5.05 (4.70–5.40) vs. 6.30 (5.73–7.23) mmol/L; P < 0.001], LDL [3.00 (2.56–3.63), 3.00 (2.70–3.70) vs. 3.90 (3.23–4.50) mmol/L; P < 0.001], and apolipoprotein B [0.88 (0.75–1.00), 0.79 (0.68–1.00) vs. 1.07 (0.90–1.24) mmol/L; P = 0.002]. PON1 basal [104 (66–260), 106 (63–250) vs. 93 (71–165) U/L; P = 0.847] and salt-stimulated paraoxonase activity [210 (131–462), 211 (120–442) vs. 180 (139–296) U/L; P = 0.857] as well as arylesterase activity [74 (63–82), 70 (54–91) vs. 70 (60–81) kU/L; P = 0.906] and PON1 phenotype (P = 0.810) were not different in the study groups.

Conclusion:

There are no differences in PON1 activity and PON1 phenotype between women with regular menstrual cycle and postmenopausal women.     

“创业管理”课程“1＋1”教学模式的研究

创业管理是创业管理课程群的基础课程。文章从“1＋1”教学模式的角度对创业管理课程的发展现状、引入必要性和建设思路与方法进行了探讨。将“1＋1”教学模式引入到教学过程中,收到了较好的效果。对提高教师教学水平,培养学生实践能力有一定的指导意义。     

“3＋1”人才培养模式企业教学基地建设研究与实践

“3＋1”人才培养模式改革是实现应用技术大学转型的有效模式,“1”是“3＋1”应用技术大学人才培养模式中的重点、难点、关键点,科学地设计校外教学环节,建设合格校外实习基地是保证“1”的校外教学顺利完成的关键,要保证校外教学实施与改革顺利完成,还必须有一套完善的组织管理机构和规章制度。     

Al2O3中空纤维陶瓷膜上TS-1膜的制备

采用相转化纺丝／烧结技术制备Al2O3多孔中空纤维膜,并以此为载体,通过晶种法考察不同晶种诱导条件制备TS-1复合中空纤维膜,并采用扫描电子显微镜、气体渗透性能测试装置等设备对所制备的TS-1复合中空纤维膜进行微观结构及渗透性能的表征。结果表明,晶种法制备的TS-1复合中空纤维膜的N2渗透速率较小,并且表面平整无缺陷,因此该方法适合制备性能优良的TS-1复合中空纤维膜。     

六周递增负荷游泳运动过程中小鼠免疫平衡的动态观察* ——流式细胞仪对Th1/Th2细胞的直接检测

研究目的:以Th1、Th2细胞为指标,观察递增负荷游泳运动过程中免疫平衡的动态变化。研究方法:雄性8周龄SPF级昆明小鼠进行六周的递增负荷游泳训练,每天一次,每周六天。分别在0周、2周、4周和6周取血,流式细胞术直接测定血液Th1、Th2细胞数量。研究结果;六周递增负荷游泳运动过程中Th1细胞数量第2周明显下降,2周、4周呈上升恢复趋势,6周时基本恢复到正常;Th2细胞运动后2周、4周和6周各组均显著上升。提示在六周的运动过程中,小鼠的体液免疫功能呈增强趋势;在六周的运动周期中,各个采样时点Th1/Th2比值都显著下降。研究结论:六周递增负荷游泳运动过程中,Th1细胞数量的下降,同时Th2细胞增多。Th1/Th2平衡向Th2一侧极化,提示免疫平衡向体液免疫侧漂移。