论基因的版权与专利权保护

在人类已经步入新千年之际,生物基因工程技术的突飞猛进给人类社会带来空前机遇的同时,也提出了的挑战。在此背景下,文章着重研究了在知识产权法律框架下如何对生物基因进行法律保护的问题,通过比较分析版权保护与专利权保护,提出了以专利制度为基础以基因进行保护的观点。并阐述了基因专利保护所面临的问题及其对策。     

Structures of Human P2Y_(12) Receptor Key to Next Generation of Antithrombotic Drugs

<正>An international team led by scientists at the Shanghai Institute of Materia Medica(SIMM),CAS has characterized the detailed structure of a receptor that plays a key role in platelet activation and blood clotting.The work has implications for treatment of cardiovascular and other diseases.In a pair of papers published by the journal Nature on May 1st,the scientists provide a detailed map of P2Y12R,a human Gi protein-coupled receptor,in the antagonist and agonist bound states.The antithrombotic drug target has a market of several billion U.S.dollars."This new work will not only deepen the understanding of activation of this receptor super-family,but will also provide invaluable insight into the improvement and development of P2Y12 drugs targeting cardiovascular and other diseases,"said team leader ZHAO Qiang,professor at SIMM."I am particularly proud of the high quality international collaboration among China,USA,and     

基于PCA的SOM网络在基因数据聚类分析中的应用

把主分量分析（PCA）方法和自组织特征映射网络（SOM）相结合,应用到基因数据聚类分析中。首先对基因数据集进行PCA分析,提取出少量的特征主分量,再对数据集进行降维。这些主分量基本上可以反映原数据集的综合信息,然后应用SOM网络对得到的特征分量进行聚类分析,把相似的基因划分到一个区域。实验结果表明,与单一地选用SOM网络进行聚类分析相比,该方法有较高的分类正确率及较为清晰的分类边界,是一种非常有效的聚类分析方法。     

肥胖基因与运动

本文就肥胖基因的结构、体内情况及运动对肥胖基因表达的影响做一综述,为运动减肥及预防肥胖引起的疾病提供参考依据,同时增加体育工作者对肥胖基因知识的了解并在以后的工作中加以运用。     

农业转基因技术的发展概况

基因工程为生物品种改造开辟了新途径，把某些高产、抗逆或优良性状基因导入原来不具备这些性状的生物体内，可以达到改良品种的目的，在农业方面，利用基因工程已取得了重大进展。     

Targeting of human aFGF gene into silkworm, Bombyx mori L.Through homologous recombination

The long-arm and short-arm genes of fibroin light chain (L-chain) of silkworm, Bombyx Mori L., and the gene of human acidic fibroblast growth factor were cloned respectively and subsequently inserted into a transfer vector pVL1392 used as a tool to target the L-chain region of the silkworm genome. Genomic DNA from their offsprings was extracted and the expected targeting was detected using polymerase chain reaction and DNA sequencing, as well as protein analysis. The results showed that positive events occurred and that the FGF gene was integrated into the L-chain locus through homologous recombination.     

Targeting of human aFGF gene into silkworm,<Emphasis Type="Italic">Bombyx mori</Emphasis> L. through homologous recombination

The long-arm and short-arm genes of fibroin light chain (L-chain) of silkworm,Bombyx Mori L., and the gene of human acidic fibroblast growth factor were cloned respectively and subsequently inserted into a transfer vector pVL 1392 used as a tool to target the L-chain region of the silkworm genome. Genomic DNA from their offsprings was extracted and the expected targeting was detected using polymerase chain reaction and DNA sequencing, as well as protein analysis. The results showed that positive events occurred and that the FGF gene was integrated into the L-chain locus through homologous recombination. Project supported by the Scientific Research Foundation for Returned Overseas Chinese Scholars, Education Ministry of China and the Natural Science Foundation of Zhejiang Province (No. 301306), China     

Genetic susceptibility to lead poisoning—A case report

Lead poisoning is well documented in persons occupationally exposed to lead. What is less known is, that even in persons working in lead based industries, the effect of lead and the appearance of signs and symptoms of lead poisoning is genetically determined. Three genes related to lead metabolism, exhibiting polymorphism have already been demonstrated-δALA-dehydratase, Vitamin D receptor gene and Hemochromatosis gene. These alleles determine the susceptibility of the individuals to lead. We present here a case of a lead acid battery worker, who presented without any signs and symptoms of lead poisoning except for a very high level of blood lead (82.8μg/dl and 47.5μg/dl 9 months later)     

Computer-related self-concept: The impact on cognitive achievement

Teaching and learning in outreach laboratories is suitable for completion of multiple hands-on experiences of students. Digital contents may support and further enrich individual haptic experiences. Nevertheless, individual variables such as computer-related self-concepts are supposed to intervene with the cognitive learning success within this context. This potential interrelationship was a major focus of our study completed in an outreach laboratory where an eLearning module specifically was integrated into a hands-on centered gene-technology module. By monitoring cognitive knowledge levels and simultaneously applying the computer-related self-concept of 162 German students (11th grade), an increase in knowledge became apparent independently of individual computer-related self-concepts. This missing relationship exemplarily fosters the assumption that computer-supported learning may suite every student regardless of computer-related self-concept scores.