现代食品的发展与展望

论文通过对现代食品中出现的各种新型食品概念的辨析 ,简单对现代食品的发展历程和现状的介绍 ,使我们对现代食品有一个清楚的认识 ,并在此基础上对它们发展前景提出了展望。     

Using Typical Infant Development to Inform Music Therapy with Children with Disabilities

This article illustrates some ways in which observations of typically-developing infants can inform music therapy and other work with children with disabilities. The research project that is described examines typical infant development with special attention to musical relatedness and communication. Videotapes of sessions centering on musical play with typically-developing infants and of music therapy sessions of children with multiple severe disabilities are examined in light of developmental issues, conceptual frameworks, and relationships between typical development and developmental issues of children with disabilities. Greenspan’s model of psychosocial development is used as a basis for analyzing observations. This research was conducted over a period of several years. Portions of what is reported here were presented at the European Music Therapy Congress, Naples, Italy (Wheeler and Stultz 2001) and the 10th World Congress of Music Therapy, Oxford, UK (Wheeler and Stultz 2002). Thanks to Elizabeth Rightmyer for very helpful feedback on the article.     

试论莆仙戏演员的嗓音保健和音乐疗法

对于莆仙戏演员而言各种嗓音病变直接影响歌唱者的舞台表现,严重者甚至会终止演员的职业生涯。本文通过对发声器官以及对导致嗓音疾病原因、症状进行的分析,有针对性地提出相关的音乐辅助疗法,以增强发声机能,从而达到莆仙戏演员的嗓音保健目的。     

禅宗思想与现代西方心理治疗流派关系解析

从禅宗的由来、主要思想为出发点,分析禅宗与现代西方各心理咨询流派的关系,并在此基础上进一步阐述了将禅宗思想融入中国心理咨询与治疗实践,实现心理咨询本土化的可行性。     

汉、回、蒙古族MBL基因Exon Ⅰ 54位密码子点突变频率及血浆含量相关性研究

目的:初步调查我国北方地区汉、回、蒙古族健康人群MBL基因ExonⅠ54位密码子点突变的情况,检测其血浆MBL含量,探讨二者的相关性。方法:用PCR-RFLP检测MBL基因点突变频率;用MBLOli-gomerELISA试剂盒测定血浆MBL含量。结果:健康汉族人该基因突变频率0.23,血浆MBL含量均值1.99±1.50mg/L,二者负相关(r=-0.62);回族人突变频率0.15,MBL含量均值3.40±2.55mg/L,二者负相关(r=-0.67);蒙古族人基因突变频率0.18,含量均值2.52±1.95mg/L,二者负相关(r=-0.64)。结论:健康汉、回、蒙古族人MBL基因54位密码子点突变频率与其血浆含量均呈负相关。     

康脑液对皮质区干细胞因子基因表达的影响

目的:在康脑液方剂干预下观察皮质区内源性神经细胞干细胞因子(SCF)mRNA在大鼠脑缺血再灌注损伤后不同时间的表达情况。方法:成年SD大鼠,以线栓法建立大脑中动脉缺血再灌注模型,随机分为模型组、药物干预组和假手术组。原位杂交技术检测脑缺血1.5h再灌注1～14d后,脑皮质区SCFmRNA表达情况。结果:脑缺血再灌注后,药物干预组、模型组SCFmRNA的表达在皮质区均明显高于假手术组,于第7天达高峰,第14天下降。结论:药物干预后脑缺血再灌注脑皮质区SCFmRNA表达在不同时间点与模型组具备相同的表达规律,两组SCFmRNA的表达无显著性差异。     

消除运动性疲劳的10种中药及其元素的研究

近20年来,国内运动医学界已开始重视并运用中药和元素等中药疗法来治疗运动性疲劳、缩短恢复时间、提高运动能力,取得了一些研究成果．本文用ICP／AES法对10种抗运动性疲劳中药中的17种元素进行了分析．研究发现：运动性疲劳与中医的“虚证”是十分相似的;中医的补虚类中药中微量元素含量与临床上治疗各种虚证的疽效有密切关系．     

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) has rapidly been developed into a robust, multifunctional genome editing tool with many uses. Following the discovery of the initial CRISPR/Cas-based system, the technology has been advanced to facilitate a multitude of different functions. These include development as a base editor, prime editor, epigenetic editor, and CRISPR interference(CRISPRi) and CRISPR activator(CRISPRa) gene regulators. It can also be used for chromatin and RNA targeting and imaging. Its applications have proved revolutionary across numerous biological fields, especially in biomedical and agricultural improvement. As a diagnostic tool, CRISPR has been developed to aid the detection and screening of both human and plant diseases, and has even been applied during the current coronavirus disease 2019(COVID-19) pandemic. CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases, including cancers, and has aided drug development. In terms of agricultural breeding, precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins, starch, oil, and other functional components for crop improvement. Adding to this, CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators. Looking to the future, increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology. This review provides an in-depth overview of current CRISPR development, including the advantages and disadvantages of the technology,recent applications, and future considerations.     

真核生物基因表达的转录后调控

本文概要叙述了在核mRNA加工成熟过程中各种调控基因表达的方式。