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51.
Exercise and treating hyperlipidaemia with statins are two integral components of the American Heart Association guidelines to reduce cardiovascular risk in adults. Since statins can cause myalgias and myopathies, they could affect the duration or intensity of an exercise regimen. To determine the impact of statin use in adult masters swimmers, a survey was distributed to examine the association between swimming performance and statin usage in adult swimmers (≥35 years). After excluding those with chronic diseases or taking drugs that reduce physical capacity, 749 swimmers (118 taking statins, 73 not taking statins to control elevated cholesterol and 558 controls) were included in a regression model to determine the factors significantly affecting the duration and intensity of swimming workouts. Age and gender were significantly (P ≤ 0.001) associated with the distance swam per 60 min. Younger, male swimmers completed more yards per 60-min workout. Use of statins was not significantly associated with yards swam per 60-min workout. Nor did statin usage affect the number of swim sessions per month or the length of swim session. Evidently, statins do not cause enough fatigue or pain in masters swimmers to require a decrease in the duration or intensity of workouts. 相似文献
52.
The establishment of new academic specialties is an intriguing research topic from a social history of science perspective. In this article we focus on the ‘scientific migration’ within the Higher Institute of Physical Education (HIPE) and the Faculty of Medicine at the State University in Ghent, Belgium. The HIPE was ‘attached’ to the Faculty of Medicine in 1908, a world first that led to an interesting triangular relationship between physical education, physiotherapy, and medicine. The physiatrists (physicians-physiotherapists) who were appointed at the HIPE had to struggle with inferior status with respect to their colleagues within the Faculty of Medicine itself. Territorial power struggles arose on several levels. In 1936, after the first generation of physicians-physiotherapists had retired, physiotherapy was integrated fully into the Faculty of Medicine, and radiology and cancer treatment – which had been considered subsectors of physiotherapy – became autonomous specialties. Physical education, however, retained its inferior academic status. 相似文献
53.
Ruszkowska B Gadomska G Bielis L Gruszka M Góralczyk B Rość D Odrowąż-Sypniewska G 《Journal of Zhejiang University. Science. B》2011,12(1):12-17
Objective
The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone, the combination of doses, the time of taking HRT, and the route of administration (oral, transdermal, implanted). The aim of the current study was to assess some parameters of coagulation, especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal HRT. 相似文献54.
Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur
for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation
of tegafur to PEI-CyD via chemical linkage was characterized by 1H NMR spectrometry and ultraviolet (UV) spectrometry. PEI-CyD-tegafur was able to condense plasmid DNA into complexes of around
150 nm with positive charge at the N/P ratio of 25, in accordance with electron microscopy observation of compact and monodisperse
nanoparticles. The results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in
B16F10 cell line. Therefore, PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and
potential for gene delivery. 相似文献
55.
Wang LR Zhang GB Chen J Li J Li MW Xu N Wang Y Shen Tu JZ 《Journal of Zhejiang University. Science. B》2011,12(3):174-179
Objective
To evaluate the predictive values of gene expressions of ribonucleotide reductase M1 (RRM1) and breast cancer susceptibility gene 1 (BRCA1) in peripheral blood from Chinese patients with non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum. 相似文献56.
Cyndi Darnell 《Sex education》2015,15(5):515-527
For most of us, sex is a subjective, lived experience that is as unique as our genetic make-up, our upbringing, our thoughts, values, feelings, beliefs and ideas. It is through our erotic interactions, or the absence thereof, that we form aspects of our fluid and mutable erotic paths and identities. Despite the proliferation of sexual imagery throughout our culture, many of us still struggle with what sex means to us, what we do, how we experience it and what that says about who we are as people. Some who struggle with this may seek the services of a psychosexual sex therapist. This paper aims to explain how such services function, why they are necessary and how the use of sexually explicit material, in some psychosexual therapeutic contexts, can help unravel the mixed responses we have to sex and our social conditioning, and enhance our overall relationship to eroticism, pleasure and general well-being. 相似文献
57.
58.
Derek J. Harmon Barbie A. Klein Cecilia Im Dylan Romero 《Anatomical sciences education》2022,15(3):620-627
Three-dimensional (3D) printing technology has become more affordable, accessible, and relevant in healthcare, however, the knowledge of transforming medical images to physical prints still requires some level of training. Anatomy educators can play a pivotal role in introducing learners to 3D printing due to the spatial context inherent to learning anatomy. To bridge this knowledge gap and decrease the intimidation associated with learning 3D printing technology, an elective was developed through a collaboration between the Department of Anatomy and the Makers Lab at the University of California, San Francisco. A self-directed digital resource was created for the elective to guide learners through the 3D printing workflow, which begins with a patient's computed tomography digital imaging and communication in medicine (DICOM) file to a physical 3D printed model. In addition to practicing the 3D printing workflow during the elective, a series of guest speakers presented on 3D printing applications they utilize in their clinical practice and/or research laboratories. Student evaluations indicated that their intimidation associated with 3D printing decreased, the clinical and research topics were directly applicable to their intended careers, and they enjoyed the autonomy associated with the elective format. The elective and the associated digital resource provided students with the foundational knowledge of 3D printing, including the ability to extract, edit, manipulate, and 3D print from DICOM files, making 3D printing more accessible. The aim of disseminating this work is to help other anatomy educators adopt this curriculum at their institution. 相似文献
59.
Matteo Vidali Vincenza Bianchi Marco Bagnati Nadia Atzeni Andrea Marco Bianchi Giorgio Bellomo 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):175-179
Introduction:
In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 – April 2012) and alcohol abuse confirmed by relatives.Case history:
At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, after double coronary artery bypass surgery, he began a pharmacological treatment with amlodipine, perindopril, atorvastatin, isosorbide mononitrate, carvedilol, ticlopidine and pantoprazole. In the next months, until may 2011, the patient resumed alcohol abuse, as confirmed by relatives; however, CDT values were repeatedly found negative (0.8% and 1.1%) despite elevated transaminases and GGT, concurrent elevated ethyl glucuronide concentration (> 50 mg/L) and blood alcohol concentration (> 1 g/L). Alcohol consumption still continued despite increasing disulfiram doses ordered by an Alcohol Rehab Center. On May 2011, the patient was transferred to a private medical center where he currently lives.Conclusions:
This study suggests the possibility that a medical therapy including different drugs may hamper the identification of chronic alcohol abusers by CDT. 相似文献60.
文章主要运用文献资料法,就运动锻炼对治疗血管性痴呆的分子机制研究进行综述。认为运动锻炼可以抗自由基损伤、抑制细胞凋亡、改善血管活性物质、调节神经递质、调控基因表达对治疗血管性痴呆有着积极的影响。 相似文献