A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge

Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with ‘catatonic depression’ and admitted to a residential mental health facility. She was referred to our hospital for further investigation 3 months later. Heteroanamnesis revealed that the symptoms had been evolving progressively over several months. Magnetic resonance imaging (MRI) of the brain showed diffuse symmetrical white matter lesions in both hemispheres. Routine laboratory tests including vitamin B12 and folic acid were normal except for a slight normocytic, normochromic anaemia. Over the next 6 weeks her symptoms deteriorated, and she became unresponsive to stimuli. A new MRI scan showed progression of the white matter lesions. The neurologist requested plasma homocysteine (Hcys) which was more than 8 times the upper limit of normal. Further testing revealed increased methylmalonic acid and the patient was diagnosed with adult-onset cobalamin C deficiency. This case illustrates that Hcys and/or methylmalonic acid should be determined in patients presenting with neuropsychiatric symptoms suggestive of vitamin B12 deficiency with a normal serum vitamin B12 to rule out a late-onset cobalamin C deficiency.     

基于政策文本视角的广东“十二五”科技政策研究

基于"政策年度""政策类型""颁布主体"和"文种类型"四位一体科技政策分析框架,对广东"十二五"期间颁布的80项科技政策样本进行统计分析,系统阐述广东"十二五"期间科技创新政策的类型分布、主要特点和存在问题,并提出若干对策建议。     

儿童焦虑与父母教养方式关系的调节变量研究

研究综合了来自中国大陆18570名3-12岁儿童的焦虑与父母教养方式相关的30项研究的数据,通过元分析的方法考查了二者相关的强度,并分析影响相关强度的因素。从总体上来说,儿童焦虑与父母教养方式存在弱相关;父母教养方式类型、儿童年龄、父母性别会对二者关系产生调节作用。建议在教养儿童过程中要采用正向的教养方式,要给予年幼儿童充分的独立自主的权利和自由,鼓励父亲参与教养,这有利于降低儿童的焦虑水平。     

船舶制冷空调系统对环境的污染及其控制对策

大气臭氧层的空洞已成为全球环境保护的焦点。中国的远洋运输船队是世界最大的船队之一。由于船用制冷空调系统在海运业的广泛使用,CFCs和HCFCs的使用使全球环境愈加恶化。从环保角度出发,本文介绍了国际上最新的CFCs和HCFCs的禁用日程及动向,比较了几种相对成熟的替代物,并从船舶制冷空调系统的操作和维护角度就如何避免环境污染提出了一些方法     

2008年欧洲杯足球赛决赛阶段各队进攻进球特征研究

通过对2008年欧洲杯足球赛决赛阶段31场比赛的73个进球特征统计发现:下半场进球数高于上半场,全场比赛结束前15min是全场比赛进球最高峰;进球方式是以脚射为主,其中,抢点直接脚射进球率最高;由前场发动组织进攻进球率最高;进球射门主要区域集中在罚球区;球门下部是进球入门的主要区域,尤其从球门右下角区域进球率最高;各位置进球数最多的仍是前锋运动员;边路进攻进球数位居各进攻形式之首;进球前经过2次传球配合后射门进球数最多,随运动员之间传球配合次数增多破门得分机率减小。     

A review of Computer Science resources for learning and teaching with K-12 computing curricula: an Australian case study

To support teachers to implement Computer Science curricula into classrooms from the very first year of school, teachers, schools and organisations seek quality curriculum resources to support implementation and teacher professional development. Until now, many Computer Science resources and outreach initiatives have targeted K-12 school-age children, with the intention to engage children and increase interest, rather than to formally teach concepts and skills. What is the educational quality of existing Computer Science resources and to what extent are they suitable for classroom learning and teaching? In this paper, an assessment framework is presented to evaluate the quality of online Computer Science resources. Further, a semi-systematic review of available online Computer Science resources was conducted to evaluate resources available for classroom learning and teaching and to identify gaps in resource availability, using the Australian curriculum as a case study analysis. The findings reveal a predominance of quality resources, however, a number of critical gaps were identified. This paper provides recommendations and guidance for the development of new and supplementary resources and future research.     

第12届欧洲杯足球赛参赛各队技战术运用能力的综合评价

对第12届世界杯足球赛16支球队31场比赛的9项攻防指标进行Q聚类统计,并对各聚类指标的差异性进行方差分析和多重比较,运用等级相关法对聚类结果进行检验,表明应用Q型聚类对球队的各项指标进行量化评价具有较高的可靠性,结果客观反映了各队技战术综合实力.揭示了欧洲足球运动的发展趋势,并探索一种较合理有效的量化评价球队技战术能力的方法.     

12届全运会女篮成年组八强球队攻防技战术特征分析

运用文献资料、逻辑分析、数理统计等方法对第12届全运会女篮成年组决赛阶段8支球队攻防各项指标进行统计分析,结果显示:各支球队得分普遍较低,得分方式不尽相同;阵地进攻手段较为单一,进攻效率低于50%以下;快攻运用次数不多,发动和接应快攻模式固定;防守投篮和突破效果较好,区域防守有待提高。建议从选材、训练、竞赛等方面进行提高和改进。     

中小企业为大企业协作配套研究——机制体系的设计与构建

基于陕西21个重点产业集群的调查,结合理论分析,设计一个具有"4-4-12"逻辑框架的协作配套机制体系并进行全面构建。"4-4-12"框架表明,能够有效促进中小企业为大企业协作配套的机制体系应至少包括4个机制12个具体措施。     

模糊控制在恒温控制系统中的应用

根据材料拉伸试验对加热炉的控制要求,本文设计了一种PID控制与模糊控制相结合的智能恒温控制系统.系统的核心控制单元采用具有模糊指令的MC9S12DG128单片机,通过在线模糊推理来实时调整PID的控制权重,实现温控系统的分段控制.实践表明,该系统具有较好的控制性能.