汽车坡道起步防溜系统设计

文章提出了一种汽车坡道起步防溜车系统设计，简洁扼要地阐述了具体的设计思路、方法。     

Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer

In human tumors, somatic mutation frequently occur in K-ras gene at codon 12, which makes the K-ras protein hyper active leading to uncontrolled signaling for cell division: one of the important hall mark of cancer. In order to correlate mutations in K-ras to cause, response to treatment, disease progression and recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) the following study was undertaken. By using PCR–RFLP method prevalence of codon 12 in K-ras gene was studied in 56 HNSCC patients. High frequency of K-ras mutation was detected in codon 12 (60.71%). The result of this study helps us in understanding the role of K-ras somatic mutations in HNSCC patients and in designing novel treatment protocols for HNSCC patients.Electronic supplementary materialThe online version of this article (10.1007/s12291-020-00882-w) contains supplementary material, which is available to authorized users.     

蛙泳运动员出发技术分析与训练

本文通过对福建省游泳队数名蛙泳运动员两种出发技术参数进行分析比较,讨论蹲踞式与抓台式出发技术的优劣,认为蹲踞式优于抓台式技术,并提出一些针对性的训练方法,以期为游泳比赛采用蹲踞式出发技术提供参考.     

《续修四库全书总目提要》订误

《续修四库全书总目提要》是继《四库全书总目》之后又一部重要的大型古籍提要目录,为治相关学问者不可或缺的重要工具书。但该书于兵乱之时成于众手,难免出现疏漏之处。本文仅就笔者所见,略作考证,不当之处敬请批评指正。     

A multilevel model of child- and classroom-level psychosocial factors that support language and literacy resilience of children in Head Start

Early exposure to the multiple risk factors associated with poverty is related to an elevated risk for academic difficulty. Therefore, it is important to promote academic resilience as early as possible and to identify factors that support resilience. Given the positive relation between early language skills and later academic outcomes, examining resilience in the domain of language and literacy is critical. Both exposure to a high-quality classroom environment and early child psychosocial strengths may serve as protective or promotive factors for low-income children, reducing the risk of poor language and literacy outcomes. Using a sample of 275 preschoolers from 29 Head Start classrooms, the current study examined the relations among teacher-reported child-level psychosocial strengths, observed classroom process quality, and growth in language and literacy. Furthermore, whether child and classroom factors had an additive or an interactive effect on outcomes was also investigated. Results indicated that child-level psychosocial strengths predicted initial levels of language and literacy, and classroom organization predicted growth. Results are discussed in terms of understanding how malleable child- and classroom-level factors are associated with language and literacy outcomes and emphasize the importance of intervening early on in young children's learning trajectories.     

An Overview of the Minnesota Approach to Research in Moral Development

This article traces the history of the Minnesota approach to moral judgement research. It is claimed that this history can be subdivided into four phases, each one associated with a different goal and theoretical consideration. Attention is also given to the issues motivating the different research goals as well as highlights of the outcomes of this work. It is concluded that the Minnesota approach has been a progressive force in the field, promoting change in both theory and measurement and also serving as a stabilising force by reaffirming Kohlberg's basic view that moral judgements are both cognitive and developmental.     

论创业教育在人才培养中的双重定位

创业教育是继创新教育之后提出的又一个教育方向。目前,我国的创业教育还处于摸索阶段,但是二者从本质上来讲,其内涵是部分重叠的。从美国的创业教育,我们可以吸取一些经验,那就是受过创业教育的学生并不一定必须创业,因为并不是每一个人都具备成为创业者的特质。创业教育之所以称之为教育,就要有一定的普遍性,所以创业教育的目标应该是培养大部分学生具备创业的素质,更全面地发展自己,而且为少部分渴望创业的学生提供能够真正创业的有力支撑。     

Relationships between families’ use of Sure Start Children’s Centres,changes in home learning environments,and preschool behavioural disorders

UK Sure Start Children’s Centres (SSCCs) aim to lessen behavioural disorders yet we lack evidence concerning how this is achieved. This study evaluates one possible mechanism: improved home learning environments (HLEs). Data come from a longitudinal study of 2568 families and children recruited at a mean age of 14 months from 117 SSCCs in England in 2012. Behavioural disorders were measured at 38 months via the Strengths and Difficulties Questionnaire. HLEs were measured at 14 and 38 months via parental interview. Families’ use of SSCCs was measured via parental interview at 14, 22, and 38 months. This study suggests that the use of SSCCs is associated with fewer preschool behavioural disorders via intermediate changes to the quality of HLE’s. Implications are discussed for social policies and for early years’ professionals.     

Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis

INTRODUCTIONHeadandneckcancersquamouscellcarci noma (HNSCC)isthefifthmostfrequentmalig nantneoplasmworld wide ;andischaracterizedbylocalinvasion ,disseminationtolocallymphnodeandfrequentrecurrenceattheprimarysiteoftumour.Despiteimprovementsindiagnosisandt…