排序方式: 共有33条查询结果,搜索用时 15 毫秒
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Josefa León-López Carmen Calderón-Soto Matías Pérez-Sánchez Belén Feriche Xavier Iglesias Diego Chaverri 《European Journal of Sport Science》2018,18(6):832-841
Using a controlled parallel group longitudinal trial design, we investigated the effects of different training interventions on the prooxidant/antioxidant status of elite athletes: living and training at moderate altitude for 3 (Hi-Hi3) and 4 weeks (Hi-Hi), and for 4 weeks too, living high and training high and low (Hi-HiLo) and living and training at sea level (Lo-Lo). From 61 swimmers, 54 completed the study. Nitrites, carbonyls, and lipid peroxidation (LPO) levels were assessed in plasma. Enzymatic antioxidants glutathione peroxidase (GPx) and glutathione reductase (GRd), and non-enzymatic antioxidants total glutathione (GST), reduced glutathione (GSH) and oxidized glutathione (GSSG) were analysed in the erythrocyte fraction. At the end of the intervention, nitrites levels were similar in all altitude groups but higher than in the Lo-Lo controls (P?=?.02). Hi-HiLo had greater GPx activity than Hi-Hi and Hi-Hi3 during most of the intervention (P?≤?.001). GRd activity was higher in Lo-Lo than in Hi-Hi at the end of the training camp (P?≤?.001). All groups showed increased levels of LPO, except Lo-Lo, and carbonyls at the end of the study (P?≤?.001). Training at altitude for 3 or 4 weeks drives oxidative stress leading to cellular damage mainly by worsening the antioxidant capacities. The GSSG/GSH ratio appears to be related to perceived exertion and fatigue. The stronger antioxidant defence showed by the Hi-HiLo group suggests an inverse relationship between redox alterations and performance. Further studies are required to investigate the role of oxidative stress in acclimatization, performance, and health. 相似文献
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Anmol Goyal Rajendra Prasad Parul Goel Amit Pal Suvarna Prasad Isha Rani 《Indian journal of clinical biochemistry : IJCB》2021,36(4):387
Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease. 相似文献
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肥胖现已成为世界范围内的一大困扰,是一种被视为威胁健康的重要疾病。近年来,研究表明从高原训练迁移而来的模拟低氧训练的模式,对减轻体重和血脂代谢有很好的改善效果,并且受到了很多关注。本研究主要通过搜集相关文献,对其进行分析和总结,探究低氧训练对机体减重的效果和可能的机制,以及对血脂等指标的影响,从而促进低氧运动的应用。 相似文献
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血红素加氧酶(heme oxygenase HE)是血红素降解过程中的限速酶,可催化血红素分解产生一氧化碳(CO),运动和缺氧会引起HO-CO系统的变化。本文就缺氧及不同负荷运动对大鼠肺动脉平滑肌细胞HO-CO系统的影响作以综述,为科学的运动训练及防止缺氧性肺动脉高压的发生提供一定的理论依据。 相似文献
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Zubieta-Calleja G Zubieta-Castillo G Zubieta-Calleja L Ardaya-Zubieta G Paulev PE 《Indian journal of clinical biochemistry : IJCB》2011,26(1):62-65
As the oxygen tension of inspired air falls with increasing altitude in normal subjects, hyperventilation ensues. This acute
respiratory alkalosis, induces increased renal excretion of bicarbonate, returning the pH back to normal, giving rise to compensated
respiratory alkalosis or chronic hypocapnia. It seems a contradiction that so many normal people at high altitude should permanently
live as chronic acid–base patients. Blood gas analyses of 1,865 subjects at 3,510 m, reported a P
aCO2 (arterial carbon dioxide tension ± SEM) = 29.4 ± 0.16 mmHg and pH = 7.40 ± 0.005. Base excess, calculated with the Van Slyke
sea level equation, is −5 mM (milliMolar or mmol/l) as an average, suggesting chronic hypocapnia. THID, a new term replacing
“Base Excess” is determined by titration to a pH of 7.40 at a P
aCO2 of 5.33 kPa (40 mmHg) at sea level, oxygen saturated and at 37°C blood temperature. Since our new modified Van Slyke equations
operate with normal values for P
aCO2 at the actual altitude, a calculation of THID will always result in normal values—that is, zero. 相似文献
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以SD大鼠为研究对象,分为常氧安静组、常氧运动组、低氧暴露组、高住低训组4大组.分别检测各组各时期大鼠体重和腓肠肌质量及肌纤维面积的变化.结果:(1)28天高住低训后大鼠体重显著下降(p<0.05);(2)28天常氧运动组、低氧暴露组、高住低训组肌肉重量显著低于对照,其中高住低训组最低,低氧暴露组其次,常氧运动组差异最小(P<0.05);(3)28天低氧暴露导致大鼠肌肉萎缩,肌纤维横截面积明显减小(p<0.05).结论:高住低训抑制大鼠肌肉的生长,可能对骨骼肌的运动机能有不利的影响. 相似文献
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低氧对体成分及骨骼肌蛋白质分解代谢的影响 总被引:2,自引:0,他引:2
了解低氧和运动对体成分及骨骼肌蛋白质分解代谢的影响,对了解肌肉收缩性能的变化有着重要的意义。为此,本文综合阐述了反映蛋白分解代:谢的一些指标及变化规律和意义,并重点介绍了低氧对体重、体成分、骨骼肌质量的影响,以及它们与蛋白分解代谢的关系,对高原训练有相当的参考价值。 相似文献