多层与高层框架的侧向变形剖析

多层与高层框架在侧力作用下的侧向变形,国内外的各资材中,都认为是“剪切型”的,或谓以“剪切型”变形为主,因而高层框架可用等效剪切梁代替之。作者认为这种说法并不正确,因高层框架的侧向变形,能与梁的剪切变形可比拟的部分,即剪切型变形的量值仅占整个变形的一小部份,而主要的还要“弯曲型”变形。此外,本文认为各资料提出的高层框一剪体系框架与剪力墙之间的相互作用力的大小与变化规律的说法亦是不妥当的。     

拇指虎口区挛缩及尺掌侧缺损的皮瓣治疗

为拇指虎口区挛缩及尺掌侧缺损的皮瓣治疗提供解剖学基础,采用新鲜成人手标本３８个,分别进行血管明胶墨汁和ＡＢＳ灌注,血管造影、大体和显微解剖观察。研究结果在第二、第三掌骨背侧有恒定的血管和神经,主要由第二掌背动脉提供可靠血供,并且在指蹼间隙与掌深弓的深部穿支有吻合支相连,还与指掌侧总动脉吻合。这种血管吻合为本术式的设计提供了形态学基础。以第二掌背动脉为蒂,在距指蹼间隙１．５ｃｍ处,可以作皮瓣面积４ｃ     

Two-stent strategy for renal artery stenosis with bifurcation lesion

Renal artery stenosis (RAS) with a bifurcation lesion is a challenge for interventional therapy. The aim of this study is to summarize our experience in RAS with a bifurcation lesion. Five patients with RAS involving bifurcation lesion are described. In cases 1 to 3, a single-stent strategy was first adopted. However, these three patients were converted to a two-stent strategy for bailout stent implantation in the side branches. In cases 4 and 5, a simultaneous kissing stent technique was performed. Angiography showed that the reference vascular diameter of the main branch was much larger than those of the side branches. Although obvious residual stenosis existed in cases 1 to 3 after stent implantation, no obvious residual stenosis was seen in cases 4 and 5. Renal artery duplex sonography was performed in cases 1 through 5 at 6, 7, 7, 8, and 6 months, respectively, after the procedures. No evidence of restenosis or occlusion was seen. In conclusion, stent implantation with the simultaneous kissing stent technique may result in more simple and more satisfactory immediate angiographic results.     

Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies简

The association between the estrogen receptor α gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16 710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.     

Role of l-Arginine on Dyslipidemic Conditions of Acute Myocardial Infarction Patients

Oxidative stress conditions associated with atherosclerosis leads to oxidative modification of low-density lipoprotein (LDL). The body’s capabilities to inhibit LDL oxidation and to remove or neutralize the atherogenic oxidized LDL (ox-LDL) are limited. When the LDL cholesterol level increases in the blood, it leads to dangerous consequences like atherosclerosis, leading to myocardial infarction. The major effect of an antioxidant in the LDL environment is to prevent the formation of ox-LDL (during atherogenesis. Strategies to reduce LDL oxidation and prevent atherogenesis can involve the enrichment of arterial cells with potent antioxidants that can prevent oxidative damage to the arterial wall. The objective of this study is to evaluate the effect of l-arginine on serum lipid and cholesterol levels in the patients of acute myocardial infarction (AMI). The study consisted of 70 AMI patients and 60 healthy individuals (serving as control) age 55–65 years. Serum levels of total cholesterol, high density lipoprotein (HDL), LDL and Triglycerides were determined on day 1 and day 15 of l-arginine administration (oral dose 3 g/day). The total cholesterol/HDL and the LDL/HDL ratio were calculated and compared. As per the observations, l-arginine administration was found to improve the lipid profile of the subjects. Hence it could be used as an adjuvant therapy for AMI and as a preventive measure for the onset of the disease in the healthy elderly also.     

文件横向运动基本原理研究

文件除具有沿时间维度做纵向运动的基本规律之外,还拥有沿空间维度做横向运动的客观规律。文章以文件横向运动为研究基础,重新梳理该理论的含义,并分别从文件属性扩展律、文件价值升级律和文件主、客体拓展律三个方面深入探究文件横向运动的基本原理。三者统一于文件之间的历史联系,体现来源原则思想的回归,闪耀着历史主义的光辉。     

Molecular Studies on Coronary Artery Disease—A Review

Coronary artery disease (CAD) remains the major cause of mortality and morbidity in the entire world population. The conventional risk factors of CAD include hypertension, hyperlipidemia, diabetes mellitus, family history, smoking etc. These factors contribute only 50 % of the total risk of CAD. For providing a complete risk assessment in CAD, it is mandatory to have well-planned clinical, biochemical and genetic studies in patients with CAD and subjects who are at risk of developing CAD. In this review an attempt is made to critically evaluate the conventional and emerging risk factors which predispose the individual to CAD. Specifically, the molecular basis of CAD including high oxidative stress, low antioxidant status and increased DNA damage are covered. A comprehensive and multifactorial approach to the problem is the better way to reduce the morbidity and mortality of the disease.     

A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest

Background  

Although computed tomography coronary angiography (CTCA) can identify coronary stenosis, little data exists on the ability of multislice computed tomography (MSCT) to detect myocardial perfusion defects at rest.     

基于深度学习的视网膜分支动脉阻塞分割

视网膜疾病如视网膜动脉阻塞等的早期诊断和治疗是预防永久性视力损伤的关键。为辅助临床眼科医生更快、更准确地诊断视网膜疾病,提出一种基于深度学习的视网膜分支动脉阻塞分割的方法。首先,将三维视网膜光学相干断层扫描图像转换为二维B超扫描图像,通过二值化、仿射变换等方法提取视网膜区域作为感兴趣区域|然后将感兴趣区域送入条件生成对抗网络进行训练,实现BRAO病变区域分割|最后,采用腐蚀、闭运算等形态学运算排除假阳性。在20张来自20双眼睛、包含BRAO急性期和萎缩期视网膜OCT图像上进行四折交叉验证,平均正确率、真阳性率、假阳性率分别为94.7%、92.1%、5.0%,表明BRAO分割方法有效。     

Communication That Changes Lives: Social Support Within an Online Health Community for ALS

Impaired communication due to a disabling illness can lead to reduced participation in community life. Online health communities can provide a substitute community for the purpose of social support and information sharing. This study examines communication between participants in an online community for patients and carers affected by Amyotrophic Lateral Sclerosis, a degenerative neurological disease affecting communication and mobility. The study finds community members engaged in a dynamic interchange of information and social support. The results contribute to understanding of communication and social support needs of people with high levels of disability.